Role of phosphatidylserine on activated platelets on tissue factor initiated blood coagulation
Project/Area Number |
24590273
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General physiology
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SUZUKI Yuko 浜松医科大学, 医学部, 准教授 (20345812)
SANO Hideto 浜松医科大学, 医学部, 助教 (80623842)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 凝固 / 線溶 / 血小板 / plasminogen / carboxylpeptidase / 血栓 |
Outline of Final Research Achievements |
Contribution of activated platelets on the initiation of coagulation cascade, fibrin formation as well as its lysis was analyzed. For the exposure of phosphatidylserine (PS) on activated platelets, integrin outside-in signals generated by platelet binding to a rigid fibrin network, and the resultant mechanical foci to stretch platelets through this binding, appeared to be essential. We also found that plasminogen binds to PS exposing platelets which then initiated fibrinolysis as starting points. This seems important to quickly dissolve generated excess amounts of thrombi in order to keep vascular patency. The accumulation of plasminogen in the center of micro-thrombuss, where platelets were exposing PS and fibrin was formed, was demonstrated from the early phase of thrombus formation. This suggests the physiological importance of coagulation-fibrinolysis cross-talk for normal hemostais.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Anti-thrombotic properties of water-soluble carbon monoxide-releasing molecules (CO-RMS).2012
Author(s)
Kramkowski K, Leszczynska A, Mogielnicki A, Chlopicki S, Fedorowicz A, Grochal E, Mann B, Brzoska T, Urano T, Motterlini R, Buczko W
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 32
Pages: 2149-2157
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Peer Reviewed
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[Presentation] PAI-1欠損症患者の半生2012
Author(s)
長橋ことみ, 岩城孝行, 宮脇由理, 鈴木敦夫, 小林隆夫,高松純樹, 松下正, 梅村和夫, 浦野哲盟, 小嶋哲人, 寺尾俊彦, 金山尚裕
Organizer
第34回 日本血栓止血学会学術集会
Place of Presentation
東京
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