| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
TRPM2 is activated by oxidative stress and is a key player in immune system. However, there are no report that the accessory protein can regulate the TRPM2 activity. Here, we found two kinds of protein which regulate TRPM2 activity, EFHC1, CD38, in this project. In hypertonic solution, the TRPM2 is regulated by CD38 and, that is involved in volume regulation mechanisms. In the brain, the TRPM2 activity is enhanced by EFHC1, that is related to epilepsy. Together, we successfully found new activation mechanisms for TRPM2 activation.
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