The new activation mechanisms in TRPM2 channel and role of cell death
Project/Area Number |
24590275
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General physiology
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | TRPM2 / TRP / イオンチャネル / 細胞容積調節 / てんかん / TRP / パッチクランプ / CD38 / EFHC1 / 国際情報交換 / EFHC1 |
Outline of Final Research Achievements |
TRPM2 is activated by oxidative stress and is a key player in immune system. However, there are no report that the accessory protein can regulate the TRPM2 activity. Here, we found two kinds of protein which regulate TRPM2 activity, EFHC1, CD38, in this project. In hypertonic solution, the TRPM2 is regulated by CD38 and, that is involved in volume regulation mechanisms. In the brain, the TRPM2 activity is enhanced by EFHC1, that is related to epilepsy. Together, we successfully found new activation mechanisms for TRPM2 activation.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering.2015
Author(s)
Nakao A, Miki T, Shimono K, Oka H, Numata T, Kiyonaka S, Matsushita K, Ogura H, Niidome T, Noebels JL, Wakamori M, Imoto K, Mori Y
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Journal Title
Pflugers Arch
Volume: 467
Issue: 4
Pages: 737-752
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 神経系の新規酸素受容体2014
Author(s)
沼田 朋大、森 泰生
Organizer
日本神経科学会学会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2014-09-12
Related Report
Invited
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[Presentation] Volume-related ion channels involved in cell survival-death switching.2013
Author(s)
Okada, Y., Sato-Numata, K., Numata, T., Wehner, F., Shimizu, T., Sakai, H., Akita, T., Okada, T.
Organizer
Bulletin of Siberian Medicine-10th International Congress:Cell Volume Regulation: Novel Therapeutic Targets & Pharmacological Approaches (CVR2013)
Place of Presentation
Moscow, Russia
Related Report
Invited
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[Presentation] Identification of novel biomarkers for vascular complications associated with autosomal dominant polycystic kidney disease using patient-specific iPSCs2012
Author(s)
Osafune K, Taura D, Shiota F, Sone M, Numata T, Toyoda T, Ameku T, Asaka I, Muso E, Mori Y, Koizumi A, Nakao K, Yamanaka S
Organizer
第10回 国際幹細胞学会
Place of Presentation
パシフィコ横浜
Related Report
Invited
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