Inhibitory mechanism of quercetin on ENaC in salt-sensitive hypertension
| Project/Area Number |
24590283
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
NIISATO Naomi 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (00237645)
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| Co-Investigator(Kenkyū-buntansha) |
MARUNAKA Yoshinori 京都府立医科大学, 大学院医学研究科, 教授 (00127036)
MIYAZAKI Hiroaki 京都府立医科大学, 大学院医学研究科, 講師 (30360027)
NAKAJIMA Kenichi 京都府立医科大学, 大学院医学研究科, 助教 (40398392)
HOSOGI Shigekuni 京都府立医科大学, 大学院医学研究科, 客員講師 (30433254)
YOKOYAMA Noriko 京都府立医科大学, 医学部, 博士研究員 (40112958)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | フラボノイド / ENaC / Na+再吸収 / ケルセチン / プロテアーゼ活性 / 食塩感受性高血圧 / Rac1 / プロスタシン |
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| Outline of Final Research Achievements |
In our previous studies, we have revealed that chronic treatment with quercetin decreased epithelial Na+ channel (ENaC)-mediated Na+ reabsorption by suppressing ENaC gene expression. In this study, we investigated the acute effect of quercetin on ENaC-mediated Na+ reabsorption and found that application of quercetin rapidly reduced ENaC-mediated Na+ reabsorption by inhibiting the protease-dependent ENaC activity and Na+, K+ ATPase activity in renal epithelial A6 cells.
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Report
(4 results)
Research Products
(26 results)
