| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Previous evidence suggested that tissue-fibrinolytic system and subsequent proteolytic system and growth factor induction play important roles in tissue repair. We therefore investigated the roles of tissue-fibrinolytic system in bone repair and regeneration in this study. We established the model to evaluate the process of bone repair and regeneration by making a bone defect in mouse femorae. We demonstrated that plasminogen is crucial for bone repair process using plasminogen-deficient mice. Moreover, tissue-type plasminogen activator (tPA) is involved in bone repair using tPA-deficient mice. In that study, we showed that tPA enhances the proliferation of osteoblasts through Annexin 2 and MAP kinase.
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