| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Outline of Final Research Achievements |
I investigated how the expression level of KCNE1 affected the slow current kinetics of a cardiac voltage-gated potassium channel KCNQ1. I found that the more binding of KCNE1 to KCNQ1, the less activity KCNQ1 showed. I also found that the longer the distance between the two subunits, the slower the activation kinetics became. In another cardiac voltage-gated potassium channel Kv4, the current kinetics was also dependent on the expression level of its auxiliary subunits KChIP4 and DPP10. The expression levels of auxiliary subunits for ion channels could be a key factor in cardiac excitability.
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