Involvement of Sirt1 in the circadian proliferation of the neural stem cells
| Project/Area Number |
24590294
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Tohoku University |
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Principal Investigator |
MORIYA Takahiro 東北大学, 薬学研究科(研究院), 准教授 (80298207)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Masaki 東北工業大学, 工学部, 教授 (90332981)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 神経幹細胞 / 体内時計 / 時計遺伝子 / Sirt1 / 脱アセチル化酵素 / 生体リズム |
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| Outline of Final Research Achievements |
In the hippacampus, it was reported that the cell division occurs during specific time-window in a day. However, its mechanism remains to be fully clarified. In this study, we tried to clarify how the molecular clock regulates the circadian proliferation of the neural stem cells. We found that Sirt1 is causally involved in the circaidan proliferation of the neural stem cells using automatic real-time monitoring system for cell division.
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Report
(4 results)
Research Products
(22 results)
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[Presentation] ROLE OF CLOCK GENE IN THE HIPPOCAMPAL NEUROGENESIS2014
Author(s)
Jun Takoda, Shiori Sudo, Asuka Mogi, Hiromu Fukuzawa, Masatake Kurita, Tokiko Suzuki, Shigenobu Shibata, Takahiro Moriya
Organizer
The 2nd Taiwan-Tohoku univeristy Neuroscience Workshop for Young Scientists
Place of Presentation
宮城県蔵王町
Year and Date
2014-12-07 – 2014-12-10
Related Report
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