Analysis of GABAergic and glutamatergic neural systems regulating paradoxical sleep.
| Project/Area Number |
24590295
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Fukushima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Kazumi 福島県立医科大学, 医学部, 講師 (90325952)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 睡眠・覚醒 / レム睡眠 / 外背側被蓋核 / 中脳中心灰白質 / 背側縫線核 / GABA / ラット / 脳・神経 / 睡眠 / 覚醒 / セロトニン / GABAニューロン / グルタミン酸ニューロン / アセチルコリンニューロン / VGAT-Vinusラット / 傍細胞記録 / 中脳周囲灰白質 / 急速眼球運動 / GABA作動性ニューロン / グルタミン酸作動性ニューロン / アセチルコリン作動性ニューロン / ニューロバイオチン / 外背側被蓋下核 |
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| Outline of Final Research Achievements |
About 70% of neurons in the mesopontine tegmentum displayed higher activity during paradoxical sleep (PS), and half of them started to increase their firing prior to the onset of PS. Most of them showed phasic activity in some periods during PS, about 40% of them discharged in synchronous with rapid eye movement. Neurons in the mesopontine tegmentum have a role in initiating PS, and in regulating phasic phenomena during PS. Neurobiotin labeling of the neurons in VGAD-vinus transgenic rats revealed that GABAergic neurons generate action potentials with shorter duration and higher firing rate. Multi units recording through multi-point electrode revealed that several serotonergic neurons in the dorsal raphe discharged synchronously, resulting in constant and tonic firing in the serotonergic neurons.
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Report
(4 results)
Research Products
(34 results)
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[Presentation] リヨンを支えた日本の睡眠研究2014
Author(s)
小山純正
Organizer
日本睡眠学会第39回定期学術集会
Place of Presentation
あわぎんホール（徳島市）
Year and Date
2014-07-03 – 2014-07-04
Related Report
Invited
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