Plastic alteration of vestibulo-cardiovascular reflex and its countermeasure
| Project/Area Number |
24590298
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Gifu University |
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Principal Investigator |
MORITA Hironobu 岐阜大学, 医学(系)研究科(研究院), 教授 (80145044)
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| Co-Investigator(Renkei-kenkyūsha) |
ABE Chikara 岐阜大学, 大学院医学系研究科, 准教授 (10585235)
TANAKA Kunihiko 岐阜医療科学大学, 教授 (60313871)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 微小重力 / 過重力 / 前庭－血圧反射 / 起立性低血圧 / 宇宙飛行士 / 前庭系の可塑性 / 起立耐性低下 / 短腕遠心機 / 過重力環境 / 前庭神経核 / グルタミン酸受容体 / 宇宙飛行 / 血圧調節 / 前庭電気刺激 |
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| Outline of Final Research Achievements |
Vestibulo-cardiovascular reflex (V-C reflex) has a significant role in controlling arterial pressure upon standing. However, the vestibular system is known to be highly plastic, thus it is possible that sensitivity of V-C reflex is suppressed if subjects are under a different gravitational environment, microgravity. This might be a responsible mechanism for post-flight orthostatic hypotension. To examine this, sensitivity of V-C reflex was examined before and after 4 to 6 months stay in the International Space Station. V-C reflex was impaired 1 day to 2 weeks after landing, and arterial pressure dropped upon standing. The impaired vestibular function can be ameliorated by subsensory weak galvanic vestibular stimulation.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Arterial pressure oscillation and muscle sympathetic nerve activity after 20 days of head-down bed rest.2013
Author(s)
Tanaka K, Nishimura N, Sato M, Kanikowska D, Shimizu Y, Inukai Y, Abe C, Iwata C, Morita H, Iwase S, Sugenoya J.
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Journal Title
Auton Neurosci
Volume: 177(2)
Issue: 2
Pages: 266-270
DOI
Related Report
Peer Reviewed
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