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Chronic stress and atopic dermatitis:Research on preventive and therapeutic effects of odorant and its mechanism

Research Project

Project/Area Number 24590299
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionTottori University

Principal Investigator

WATANABE TATSUO  鳥取大学, 医学部, 教授 (60182929)

Co-Investigator(Kenkyū-buntansha) MIYOSHI Michio  鳥取大学, 医学部, 助教 (20093627)
KOBA Satoshi  鳥取大学, 医学部, 講師 (40565743)
UMEKITA Yoshihisa  鳥取大学, 医学部, 教授 (80244226)
庄盛 浩平  鳥取大学, 医学部, 講師 (60314572)
Co-Investigator(Renkei-kenkyūsha) YAMADA Nanako  鳥取大学, 医学部附属病院, 准教授 (10304213)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywordsアトピー性皮膚炎 / 香料 / ストレス / 皮膚バリア / 角質水分量 / ピクリルクロライド
Outline of Final Research Achievements

We investigated whether inhalation of green odor or rose odor cures and/or prevents the atopic dermatitis (AD) induced in mice and human. The green odor had no effect on the AD in mice. On the other hand, the AD patient inhaling the rose odor had more skin hydration than those without the odor. The present results suggest that rose odor has a therapeutic effect on AD in human.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Central command dysfunction in rats with heart failure is mediated by brain oxidative stress and normalised by exercise training.2014

    • Author(s)
      Koba, S., Hisatome, I. and Watanabe, T.
    • Journal Title

      Journal of Physiology (London)

      Volume: 592 Issue: 17 Pages: 3917-3931

    • DOI

      10.1113/jphysiol.2014.272377

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Running training attenuates blood pressure and norepinephrine responses to immobilization stress in spontaneously hypertensive rats2013

    • Author(s)
      Miyoshi, M. & Watanabe T.
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 2 Issue: 3 Pages: 365-372

    • DOI

      10.7600/jpfsm.2.365

    • NAID

      10031179363

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress exaggerates skeletal muscle contraction-evoked reflex sympathoexcitation in rats with hypertension induced by angiotensin II. American Journal of Physiology2013

    • Author(s)
      Koba, S., Watanabe, R., Kano, N. and Watanabe, T
    • Journal Title

      Heart and Circulatory Physiology

      Volume: 304 Issue: 1 Pages: H142-H153

    • DOI

      10.1152/ajpheart.00423.2012

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of "rose essential oil" inhalation on stress-induced skin-barrier disruption in rats and humans2012

    • Author(s)
      Fukada M., et al
    • Journal Title

      Chemical Senses

      Volume: 37 Issue: 4 Pages: 347-356

    • DOI

      10.1093/chemse/bjr108

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exercise pressor reflex function in female rats fluctuates with the estrous cycle.2012

    • Author(s)
      Koba, S., Yoshinaga, K., Fujita, S., Miyoshi, M. and Watanabe, T.
    • Journal Title

      Journal of Applied Physiology

      Volume: 113(5) Issue: 5 Pages: 719-726

    • DOI

      10.1152/japplphysiol.00396.2012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of an e-learning distance education system in the graduate school of medical sciences of Tottori University2012

    • Author(s)
      Houri, D., Watanabe, T., Hayashi, K. & Kurozawa, Y.
    • Journal Title

      Yonago Acta Medica

      Volume: 55 Pages: 69-73

    • NAID

      120005032394

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ストレスによる甘味・うま味受容体発現抑制の機序~グルココルチコイドの関与について~2015

    • Author(s)
      渡邊達生、小川修史、領家和男
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場・展示場(神戸市)
    • Year and Date
      2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] ホワイトノイズ音暴露時のラット心拍数調節における中脳中心灰白質の役割2014

    • Author(s)
      木場智史、井上崚、渡邊達生
    • Organizer
      第66回日本生理学会中国四国地方会
    • Place of Presentation
      情報通信交流館 e-とぴあ・かがわ(髙松市)
    • Year and Date
      2014-11-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 心不全ラットにおける恐怖時徐脈応答の異常2014

    • Author(s)
      木場智史、久留一郎、渡邊達生
    • Organizer
      日本生理学会大会
    • Place of Presentation
      鹿児島大学 郡元キャンパス(鹿児島市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Tiron, a superoxide scavenger, suppresses fictive locomotionevoked sympathoexcitation in rats with heart failure2013

    • Author(s)
      Koba, S., Inoue, Y., Hosatome, I., & Watanabe, T.
    • Organizer
      Experimental Biology
    • Place of Presentation
      Boston Convention & Exposition Center (Boston, USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] バラの香りを吸入するとストレスによる皮膚バリア障害が抑制される ~ラットとヒトを用いた検討~2013

    • Author(s)
      弓岡英里、深田美香、渡邊達生
    • Organizer
      日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] 心筋梗塞ラットの運動トレーニングは中枢性交感神経賦活応答を抑制する2012

    • Author(s)
      木場智史、井上裕美子、久留一郎、渡邊達生
    • Organizer
      日本生理学会中国四国地方会
    • Place of Presentation
      高知市文化プラザ かるぽーと(高知市)
    • Related Report
      2012 Research-status Report
  • [Remarks] 統合生理学分野 I 統合生理学分野

    • URL

      http://www.med.tottori-u.ac.jp/intgphys/6005.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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