Central mechanism of heat acclimation
| Project/Area Number |
24590300
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIDO Osamu 島根大学, 医学部, 教授 (40175386)
KATAKURA Masanori 島根大学, 医学部, 助教 (40383179)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 暑熱馴化 / 視床下部 / 体温調節 / 環境生理学 / 神経新生 / 選択環境温度 |
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| Outline of Final Research Achievements |
In humans and rodents, repeated exposure to moderate heat has been well known to result in the development of heat acclimation that improves heat tolerance. The present study investigated a relationship between the improvement of heat-tolerance and the heat exposure-induced hypothalamic neurogenesis in rats. Immunohistochemical analysis showed that the numbers of BrdU-positive cells in the hypothalamus were increased in heat acclimated rats. The number of BrdU-positive cells double-stained by a mature neuron marker increased abruptly after 43 days of heat exposure. Moreover, administration of cytosine arabinoside, a mitosis inhibitor, into rats’ intra-cerebral ventricle significantly reduced heat exposure-induced improvement of heat-tolerance. These results suggest that heat exposure facilitates proliferation of neuronal progenitor cells in the hypothalamus and promotes differentiation into neurons, which might have a certain role in improvement of heat tolerance.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Long-term Heat Exposure Prevents Hypoxia-Induced Apoptosis in Mouse Fibroblast Cells2014
Author(s)
Sugimoto N, Shido O, Matsuzaki K, Katakura M, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H
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Journal Title
Cell biochemistry and biophysics
Volume: (in press)
Issue: 1
Pages: 301-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action.2013
Author(s)
Kawahata I, Yoshida M, Sun W, Nakajima A, Lai Y, Osaka N, Matsuzaki K, Yokosuka A, Mimaki Y, Naganuma A, Tomioka Y, Yamakuni T.
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Journal Title
J Neural Transm
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Upregulation of aquaporin expression in the salivary glands of heat-acclimated rats2013
Author(s)
N Sugimoto, K Matsuzaki, H Ishibashi, M Tanaka, T Sawaki, Y Fujita, T Kawanami, Y Masaki, T Okazaki, J Sekine, S Koizumi, A Yachie, H Umehara, O Shido
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Journal Title
Scientific Reports
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Cellular heat acclimation regulates cell growth, cell morphology, mitogen-activated protein kinase activation, and expression of aquaporins in mouse fibroblast cells2012
Author(s)
Sugimoto N, Shido O, Matsuzaki K, Ohno-Shosaku T, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H
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Journal Title
Cell Physiol Biochem.
Volume: 30
Issue: 2
Pages: 450-457
DOI
Related Report
Peer Reviewed
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