Total research for the sarcopenia from rats to human using multiple level analysis, such as motor unit in vivo, cell, molecule and nucleic acid.

• Project/Area Number: 24590303
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Tokai University
• Principal Investigator: TAMAKI Tetsuro 東海大学, 医学部, 准教授 (10217177)
• Co-Investigator(Renkei-kenkyūsha): UCHIYAMA Yoshiyasu 東海大学, 医学部, 准教授 (80317784) ; HOSHI Akio 東海大学, 医学部, 准教授 (90453711)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 運動単位 / アミノ酸代謝 / サイミジン代謝 / Ib抑制 / 筋張力測定 / 放射性同位元素 / 骨格筋内幹細胞 / dynapenia / sarcopenia / human skeletal muscle / stem cells / proliferation / synaptic depression / neuromuscular junction / motor neuron pool / stretch-reflex / fall / demyelination / axon loss / 生理学 / 萎縮筋 / サルコペニア / 加齢 / モーターユニット

Outline of Final Research Achievements

The physiological mechanisms of the age-related loss of muscle mass (sarcopenia) was investigated for preventive purposes. The results suggested that the symptoms such as alteration of motor units, slower muscle contraction velocity and the functional reduction of sarcoplasmic reticulum, already began in middle aged that showed no other signs of sarcopenia. Thus, prevention should be started in middle age that could be retained relatively higher movement ability. In addition, in vivo cellular environment, such as the cachexia with reduced physical activities, may be a major cause for sarcopenia and/or dynapenia with a functional depression of muscle-derived cells. Therefore, stable nutrient intake and maintaining of humoral balance are important for the prevention.

Research Products

• [Journal Article] Qualitative alteration of peripheral motor system begins prior to appearance of typical sarcopenia syndrome in middle-aged rats. (2014)
  • Author(s): Tetsuro Tamaki, Maki Hirata, Yoshiyasu Uchiyama.
  • Journal Title: Front Aging Neurosci Volume: 6
  • DOI: 10.3389/fnagi.2014.00296
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Multipotent differentiation of human skeletal muscle-derived cells (Sk-Cs): Comparison to mouse Sk-Cs. (2015)
  • Author(s): Tetsuro Tamaki, Yoshiyasu Uchiyama, Hiroyuki Hashimoto, Nobuyuki Nakajima, Kosuke Saito, Shuichi Soeda, Maki Hirata.
  • Organizer: 第１２０回日本解剖学会、第９２回日本生理学会合同大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2015-03-21 – 2015-03-23