Enriched environment on stress-induced abnormal behaviors

• Project/Area Number: 24590304
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Meijo University
• Principal Investigator: MAMIYA Takayoshi 名城大学, 薬学部, 准教授 (70340297)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 飼育環境 / 精神疾患 / 疾患予防 / 自発活性 / 脳機能

Outline of Final Research Achievements

The purpose of this study was to clarify the endogenous system to protect the psychiatric disease. Firstly, DNA array showed more than 100 molecules expressed highly in the mouse brain by environmental enrichment for 4 weeks. One of them, dynorphin A, an endogenous opioid peptide, increased by the running wheel in the brain. Additionally, dynorphin A (1-13), a potent fragment of this peptide prevented repeated stress-induced behavioral impairments in mice. These results suggest that dynorphin might be induced to express in the brain by enriched environment and might alleviate the stress-induced behavioral impairments.

Research Products

• [Journal Article] Combination of neonatal PolyI:C and adolescent phencyclidine treatments is required to induce behavioral abnormalities with overexpression of GLAST in adult mice (2014)
  • Author(s): Hirotake Hida, Akihiro Mouri, Yu Ando, Kentaro Mori, Takayoshi Mamiya, Kunihiro Iwamoto, Norio Ozaki, Kiyofumi Yamada, Toshitaka Nabeshima, Yukihiro Noda
  • Journal Title: Behavioural Brain Research Volume: 258 Pages: 34-42
  • DOI: 10.1016/j.bbr.2013.09.026
  • Peer Reviewed / Open Access
• [Journal Article] Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence (2014)
  • Author(s): Toriumi K, Kondo M, Nagai T, Hashimoto R, Ohi K, Song Z, Tanaka J, Mouri A, Koseki T, Yamamori H, Furukawa-Hibi Y, Mamiya T, Fukushima T, Takeda M, Nitta A, Yamada K, Nabeshima T
  • Journal Title: Int J Neuropsychopharmacol Volume: 17 Issue: 03 Pages: 443-453
  • DOI: 10.1017/s1461145713001302
  • Peer Reviewed / Open Access
• [Journal Article] Roles of endogenous kappa-opioid systems in stress-related behavioral changes in mice. --Behavioral and neurochemical analysis in the learned helplessness test― (2014)
  • Author(s): Mamiya T.
  • Journal Title: J. Res. Inst. Meijo Univ. Volume: 13 Pages: 11-18
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor. (2014)
  • Author(s): Aoyama Y, Mouri A, Toriumi K, Koseki T, Narusawa S, Ikawa N, Mamiya T, Nagai T, Yamada K, Nabeshima T.
  • Journal Title: Int J Neuropsychopharmacol. Volume: 17 Issue: 05 Pages: 723-737
  • DOI: 10.1017/s1461145713001466
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dynorphin A (1–13) Alleviated Stress-Induced Behavioral Impairments in Mice (2014)
  • Author(s): Mamiya T, Hasegawa Y, Hiramatsu M.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 37 Issue: 8 Pages: 1269-1273
  • DOI: 10.1248/bpb.b14-00006
  • NAID: 130004677531
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pregerminated brown rice enhanced NMDA receptor /CaMKIIα signaling in the frontal cortex of mice. (2014)
  • Author(s): Mamiya T, Morikawa K, Kise M.
  • Journal Title: J Rice Res. Volume: 2 Issue: 2 Pages: 123-123
  • DOI: 10.4172/jrr.1000123
  • Peer Reviewed / Open Access
• [Journal Article] Behavioral characterization of mice overexpressing human dysbindin-1 (2014)
  • Author(s): Shintani N, Onaka Y, Hashimoto R, Takamura H, Nagata T, Umeda-Yano S, Mouri A, Mamiya T, Haba R, Matsuzaki S, Katayama T, Yamamori H, Nakazawa T, Nagayasu K, Ago Y, Yagasaki Y, Nabeshima T, Takeda M, Hashimoto H
  • Journal Title: Molecular Brain Volume: 7(1) Issue: 1 Pages: 74-74
  • DOI: 10.1186/s13041-014-0074-x
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] SHATI/NAT8L regulates neurite outgrowth via microtubule stabilization (2014)
  • Author(s): K Toriumi, M Ikami, M Kondo, A Mouri, T Koseki, D Ibi, Y Furukawa-Hibi, T Nagai, T Mamiya, A Nitta, K Yamada and T Nabeshima
  • Journal Title: Journal of Neuroscience Research Volume: 91 Issue: 12 Pages: 1525-1532
  • DOI: 10.1002/jnr.23273
  • Peer Reviewed
• [Journal Article] Evaluation of emotional behaviors in young offspring of C57BL/6J mice after gestational and/or perinatal exposure to nicotine in six different time-windows. (2013)
  • Author(s): Tursun Alkama, Hyoung-Chun Kim, Masayuki Hiramatsu, Takayoshi Mamiya, Yuki Aoyama, Atsumi Nitta, Kiyofumi Yamada, Toshitaka Nabeshima.
  • Journal Title: Behav Brain Res Volume: 239 Pages: 80-89
  • DOI: 10.1016/j.bbr.2012.10.058
  • Peer Reviewed
• [Journal Article] Temporal association of elevated cholecystokininergic tone and adolescent trauma is critical for posttraumatic stress disorder-like behavior in adult mice. (2013)
  • Author(s): Anu Joseph, Mingxi Tang, Takayoshi Mamiya, Qian Chen, Ling-Ling Yang, Jianwei Jiao, Na Yu, and Ya-Ping Tang
  • Journal Title: Proc Natl Acad Sci USA Volume: 110 (16) Issue: 16 Pages: 6589-6594
  • DOI: 10.1073/pnas.1219601110
  • Peer Reviewed
• [Journal Article] Evaluation of cognitive behaviors in young offspring of C57BL/6J mice after gestational nicotine exposure during different time-windows. (2013)
  • Author(s): Tursun Alkam, Hyoung-Chun Kim, Takayoshi Mamiya, Kiyofumi Yamada, Masayuki Hiramatsu, Toshitaka Nabeshima
  • Journal Title: Psychopharmacology (Berl) Volume: 230 (3) Issue: 3 Pages: 451-463
  • DOI: 10.1007/s00213-013-3175-9
  • Peer Reviewed
• [Journal Article] Intake of food pellets containing pre-germinated brown rice alleviates cognitive deficits caused by beta-amyloid peptide25-35 in mice: Implication of lipid peroxidation. (2013)
  • Author(s): Takayoshi Mamiya, Keiko Morikawa, Makoto Ukai M, Mitsuo Kise
  • Journal Title: J Rice Res Volume: 1 (2) Issue: 2 Pages: 116-116
  • DOI: 10.4172/jrr.1000116
  • Peer Reviewed
• [Journal Article] Ubiquitin-Specific Peptidase 46 (Usp46) Regulates Mouse Immobile Behavior in the Tail Suspension Test through the GABAergic System (2012)
  • Author(s): Imai S, Mamiya T, Tsukada A, Sakai Y, Mouri A, Nabeshima T, Ebihara S
  • Journal Title: PLoS One Volume: 7(6) Issue: 6 Pages: e39084-e39084
  • DOI: 10.1371/journal.pone.0039084
  • Peer Reviewed
• [Journal Article] Prenatal NMDA Receptor Antagonism Impaired Proliferation of Neuronal Progenitor, Leading to Fewer Glutamatergic Neurons in the Prefrontal Cortex (2012)
  • Author(s): Toriumi K, et al
  • Journal Title: Neuropsychopharmacology Volume: (In press) Issue: 6 Pages: 1387-1396
  • DOI: 10.1038/npp.2011.324
  • Peer Reviewed
• [Journal Article] Mouse strain differences in phencyclidine-induced behavioral changes (2012)
  • Author(s): Mouri A, et al
  • Journal Title: Int J Neuropsychopharmacol Volume: (In press) Issue: 06 Pages: 767-79
  • DOI: 10.1017/s146114571100085x
  • Peer Reviewed
• [Journal Article] Exposure to enriched environments during adolescence prevents abnormal behaviours associated with histone deacetylation in phencyclidine-treated mice (2012)
  • Author(s): Koseki T, et al
  • Journal Title: Int J Neuropsychopharmacol Volume: (In press) Issue: 10 Pages: 1489-1501
  • DOI: 10.1017/s1461145711001672
  • Peer Reviewed
• [Presentation] 胎生期ニコチン曝露が成熟期の学習・記憶機能に及ぼす影響 (2015)
  • Author(s): 羽田麻希、間宮隆吉、角田侑紀、榊原奈美、宋由香、吉田あや、青山雄紀、鍋島俊隆、平松正行
  • Organizer: 第135回日本薬学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26
• [Presentation] 前脳特異的コレシストキニン受容体タイプ2過剰発現マウスの行動解析 (2015)
  • Author(s): 太田浩平、間宮隆吉、長屋有紀、鍋島俊隆、唐亜平、平松正行
  • Organizer: 第135回日本薬学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26
• [Presentation] Shati遺伝子欠損マウスにおける注意力欠損 (2015)
  • Author(s): 可知菜都美、間宮隆吉、田中絢子、鳥海和也、新田淳美、鍋島俊隆、平松正行
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-03-20
• [Presentation] ストレス誘発精神障害モデルの作製およびコーピング法の開発～胎児期社会的心理ストレスによる行動障害と豊かな環境下飼育による緩解作用～ (2014)
  • Author(s): 間宮隆吉、大橋玄季、長屋有紀、宮村美崇、平松正行
  • Organizer: 第41回日本脳科学会
  • Place of Presentation: 福井
  • Year and Date: 2014-11-23
• [Presentation] 前脳コレシストキニン受容体の学習・記憶課題における役割 (2014)
  • Author(s): 間宮隆吉、長屋有紀、太田浩平、神田沙也加、中村綾乃、Anu Joseph、Mingxi Tang、Qian Chen、LingLing Yang、Jianwei Jiao、Na Yu、Ya-Ping Tang、鍋島俊隆、平松正行
  • Organizer: 第24回日本臨床精神神経薬理学会・第44回日本神経精神薬理学会 合同年会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-11-21
• [Presentation] 胎生期ニコチン暴露が成熟期の学習記憶機能に及ぼす影響 (2014)
  • Author(s): 間宮隆吉、羽田麻希、角田侑紀、榊原奈美、宋由香、吉田あや、青山雄紀、AlkamTurson、鍋島俊隆、平松正行
  • Organizer: 第126回日本薬理学会近畿部会
  • Place of Presentation: 和歌山
  • Year and Date: 2014-10-24
• [Presentation] 精神的ストレス連続負荷が雄性マウスの性行動に及ぼす影響 (2014)
  • Author(s): 長谷川裕也、間宮隆吉、平松正行
  • Organizer: 第60回（平成26年度）日本薬学会東海支部総会・大会
  • Place of Presentation: 鈴鹿
  • Year and Date: 2014-07-05
• [Presentation] Shati KOマウスのAD/HDモデルマウスとしての妥当性評価 (2014)
  • Author(s): 田中絢子、鳥海和也、渡辺裕之、可知菜都美、毛利彰宏、古関竹直、新田淳美、間宮隆吉、鍋島俊隆、平松正行
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] 恐怖条件付け学習課題に対する若齢期ストレスの影響～前脳コレシストキニン受容体過剰発現マウスを用いた検討～ (2013)
  • Author(s): 間宮隆吉、Anu Joseph、Mingxi Tang、Qian Chen、Ling-Ling Yang、Jianwei Jiao、Na Yu、Ya-Ping Tang、鍋島俊隆、平松正行
  • Organizer: 第40回日本脳科学会
  • Place of Presentation: 浜松
• [Presentation] Repeated prenatal psychological stress induces emotional deficits in the adolescence. (2013)
  • Author(s): Genki Ohashi, Yuki Tsuruoka, Yoshitaka Miyamura, Takenao Koseki, Akihiro Mouri, Masayuki Hiramatsu, Takayoshi Mamiya, Toshitaka Nabesima
  • Organizer: 第８６日本薬理学会年会
  • Place of Presentation: 福岡
• [Presentation] コレシストキニンシステムは心理的ストレス負荷誘発行動障害を緩解する (2012)
  • Author(s): 間宮隆吉、大橋玄季、鶴岡裕生、宮村美嵩、古関竹直、毛利彰宏、 鍋島俊隆、平松正行
  • Organizer: フォーラム2012：衛生薬学・環境トキシコロジー
  • Place of Presentation: 名古屋
• [Presentation] 若齢期のストレス刺激は成熟期のすくみ行動を増強する：脳内コレシストキニン受容体の関与
  • Author(s): 間宮隆吉、Anu Joseph、Mingxi Tang、Qian Chen、Ling-Ling Yang、Jianwei Jiao、Na Yu、Ya-Ping Tang、鍋島俊隆、平松正行
  • Organizer: 第123回日本薬理学会近畿部会
  • Place of Presentation: 名古屋
• [Presentation] コレシストキニンシステムの情動機能解析
  • Author(s): 太田浩平、間宮隆吉、長屋有紀、鍋島俊隆、唐 亜平、平松正行
  • Organizer: 第23回神経行動薬理若手研究者の集い
  • Place of Presentation: 仙台
• [Presentation] ストレスモデルマウスの作製とストレス解消
  • Author(s): 間宮隆吉、平松正行
  • Organizer: 第23回神経行動薬理若手研究者の集いシンポジウム
  • Place of Presentation: 仙台
• [Remarks] 名城大学HP
  • URL: http://www.meijo-u.ac.jp/