| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Activation of the sympathetic nerves to the ovary reduces ovarian blood flow. In the present study, effects of chronic estradiol treatment on the sympathetically-induced reduction of ovarian blood flow, and the ovarian estradiol secretion rate were examined. Chronic subcutaneous infusion of estradiol (28 days) stopped normal menstrual cycles and the cyclic changes of ovarian estradiol secretion rate. Furthermore, chronic estradiol treatment attenuated the sympathetically-induced reduction of ovarian blood flow. This attenuation effects of estradiol were significantly appeared to the blood flow responses to the sympathetic stimulation at low frequency (2Hz) but not at high frequency (20Hz). Since sympathetic activity at rest is 1-3 Hz in general, chronic elevation of estradiol may attenuate the sympathetically-induced reduction of ovarian blood flow under the resting condition.
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