Plastic changes in function of ovarian sympathetic innervation induced by estrogen

• Project/Area Number: 24590308
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: UCHIDA Sae 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (90270660)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 卵巣 / 交感神経 / エストロゲン / 可塑性 / ラット

Outline of Final Research Achievements

Activation of the sympathetic nerves to the ovary reduces ovarian blood flow. In the present study, effects of chronic estradiol treatment on the sympathetically-induced reduction of ovarian blood flow, and the ovarian estradiol secretion rate were examined. Chronic subcutaneous infusion of estradiol (28 days) stopped normal menstrual cycles and the cyclic changes of ovarian estradiol secretion rate. Furthermore, chronic estradiol treatment attenuated the sympathetically-induced reduction of ovarian blood flow. This attenuation effects of estradiol were significantly appeared to the blood flow responses to the sympathetic stimulation at low frequency (2Hz) but not at high frequency (20Hz). Since sympathetic activity at rest is 1-3 Hz in general, chronic elevation of estradiol may attenuate the sympathetically-induced reduction of ovarian blood flow under the resting condition.

Research Products

• [Journal Article] Autonomic nervous regulation of ovarian function by noxious somatic afferent stimulation. (2015)
  • Author(s): Uchida, S. , Kagitani, F.
  • Journal Title: Journal of Physiological Sciences Volume: 65 Issue: 1 Pages: 1-9
  • DOI: 10.1007/s12576-014-0324-9
  • NAID: 40020323497
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sympathetic regulation of estradiol secretion from the ovary. (2015)
  • Author(s): Uchida, S.
  • Journal Title: Autonomic Neuroscience: Basic & Clinical Volume: 187 Pages: 27-35
  • DOI: 10.1016/j.autneu.2014.10.023
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 自律神経と排卵 (2015)
  • Author(s): 内田さえ
  • Journal Title: 女性心身医学 Volume: 19 Pages: 278-281
• [Journal Article] Effects of electrical stimulation of autonomic nerves to the ovary on the ovarian testosterone secretion rate in rats. (2014)
  • Author(s): Uchida S, Kagitani F.
  • Journal Title: Autonomic Neuroscience: Basic and Clinical. Volume: 180 Pages: 48-52
  • DOI: 10.1016/j.autneu.2013.10.007
  • Peer Reviewed
• [Journal Article] 体性-自律神経反射と鍼灸 (2014)
  • Author(s): 内田さえ
  • Journal Title: Biomedical Thermology Volume: 33 Pages: 41-46
• [Journal Article] The missing link between long-term stimulation of nicotinic receptors and the increases of acetylcholine release and vasodilation in the cerebral cortex of aged rats. (2013)
  • Author(s): Uchida S, Hotta H, Misawa H, Kawashima K
  • Journal Title: J Physiol Sci Volume: 63 Issue: 2 Pages: 95-101
  • DOI: 10.1007/s12576-012-0239-2
  • NAID: 10031169593
  • Peer Reviewed
• [Journal Article] ストレス時の卵巣エストラジオール分泌低下における交感神経の役割 (2013)
  • Author(s): 内田さえ
  • Journal Title: 自律神経 Volume: 50 Pages: 39-44
  • NAID: 10031163538
  • Peer Reviewed
• [Journal Article] Reflex modulation of ovarian estradiol secretion by noxious mechanical stimulation of a hindpaw in anesthetized rats. (2012)
  • Author(s): Uchida, S., Kagitani, F., Hotta, H.
  • Journal Title: Autonomic Neuroscience, Basic and Clinical Volume: 171 Issue: 1-2 Pages: 14-20
  • DOI: 10.1016/j.autneu.2012.08.014
  • Peer Reviewed
• [Journal Article] Autonomic boundary conditions for ventricular fibrillation and their implications for a novel defibrillation technique. (2012)
  • Author(s): Naggar, I., Uchida, S., Kamran, H., Lazar, J., Stewart, M.
  • Journal Title: Journal of Physiological Sciences Volume: 62 Issue: 6 Pages: 479-492
  • DOI: 10.1007/s12576-012-0225-8
  • NAID: 10031127106
  • Peer Reviewed
• [Presentation] 卵巣交感神経の血管収縮反応に対するエストロゲンの可塑的影響 (2015)
  • Author(s): 鍵谷方子, 内田さえ
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] 自律神経研究の最新の進歩 (2015)
  • Author(s): 内田さえ
  • Organizer: 千葉県鍼灸師会生涯研修学術講習会
  • Place of Presentation: 千葉
  • Year and Date: 2015-02-08
  • Invited
• [Presentation] 内分泌腺静脈血の直接採集によるホルモン分泌速度評価システム (2015)
  • Author(s): 内田さえ, 渡辺信博, 堀田晴美
  • Organizer: TOBIRA第4回研究交流フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2015-02-02
• [Presentation] 卵巣障害時の卵巣求心性神経活動と循環反応 (2014)
  • Author(s): 内田さえ, 鍵谷方子
  • Organizer: 第67回日本自律神経学会総会
  • Place of Presentation: 埼玉
  • Year and Date: 2014-10-30 – 2014-10-31
• [Presentation] Regulatory mechanism of testosterone secretion from the ovary by autonomic nerves (2014)
  • Author(s): 内田さえ, 鍵谷方子
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] 自律神経機能と排卵 (2014)
  • Author(s): 内田さえ
  • Organizer: 第43回日本女性心身医学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-08-09 – 2014-08-10
  • Invited
• [Presentation] 鍼灸刺激が卵巣機能に及ぼす影響 (2014)
  • Author(s): 内田さえ
  • Organizer: 第65回日本東洋医学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-27 – 2014-06-29
  • Invited
• [Presentation] Reflex modulation of ovarian estradiol secretion via the superior ovarian nerve by somatosensory stimulation in rats. (2013)
  • Author(s): Uchida S., Kagitani F, Hotta H.
  • Organizer: The 8th Congress of the International Society for Autonomic Neuroscience (ISAN)
  • Place of Presentation: Giessen, Germany
• [Presentation] Autonomic regulation of ovarian function by somatic afferent stimulation. (2013)
  • Author(s): Uchida S
  • Organizer: International Scientific Acupuncture and Meridian Symposium (iSAMS 2013)
  • Place of Presentation: Stockholm, Sweden
  • Invited
• [Presentation] 体性ー自律神経反射と鍼灸 (2013)
  • Author(s): 内田さえ
  • Organizer: 日本サーモロジー学会第30回大会
  • Place of Presentation: つくば
  • Invited
• [Presentation] 卵巣交感神経の血管収縮反応に対するエストロゲンの可塑的影響 (2013)
  • Author(s): 内田さえ，鍵谷方子
  • Organizer: 第66回日本自律神経学会総会
  • Place of Presentation: 名古屋
• [Presentation] Neural mechanism for stress-induced inhibition of estradiol secretion from the ovary. (2012)
  • Author(s): Uchida S., Kagitani, F., Hotta, H.
  • Organizer: he 35th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2012)
  • Place of Presentation: Nagoya
• [Presentation] 体性感覚刺激と自律機能―皮膚からの反射に重点をおいてー (2012)
  • Author(s): 内田さえ
  • Organizer: 第8回公益法人 日本鍼灸師会 全国大会
  • Place of Presentation: 大宮
  • Invited
• [Presentation] 交感神経刺激が卵巣テストステロン分泌に及ぼす影響 (2012)
  • Author(s): 内田さえ，鍵谷方子，堀田晴美
  • Organizer: 第65回日本自律神経学会総会
  • Place of Presentation: 東京
• [Presentation] 卵巣交感神経刺激が卵巣テストステロン分泌に及ぼす影響
  • Author(s): 鍵谷方子，内田さえ
  • Organizer: 第41回 自律神経生理研究会
  • Place of Presentation: 東京