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Suppressive role of histamine in hepatic colorectal cancer matastasis

Research Project

Project/Area Number 24590322
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General pharmacology
Research InstitutionYamaguchi University

Principal Investigator

KURAMASU Atsuo  山口大学, 医学(系)研究科(研究院), 准教授 (90302091)

Co-Investigator(Kenkyū-buntansha) YOSHIMURA Kiyoshi  国立研究開発法人国立がん研究センター, 先端医療開発センター, 分野長 (30346564)
TAMADA Koji  山口大学, 大学院医学系研究科, 教授 (00615841)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsヒスタミン / 大腸癌 / 肝転移 / 制御性T細胞 / ヒスチジン脱炭酸酵素 / 制御性T細胞 / ハイドロダイナミックインジェクション
Outline of Final Research Achievements

Role of histamine in hepatic colorectal cancer matastasis was investigated using mice deficient of endogenous histamine. In mouse hepatic colorectal cancer matastasis model, mice lacking histamine-synthesizing enzyme showed significantly shorter survival, suggesting that histamine had suppressive role in hepatic metastatis. In spleen and liver from histamine-deficient mice with hepatic metastasis, regulatory T cells were significantly increased, showing a possible mechanism of Treg-mediated suppression of anti-tumor immune response.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2014 2012

All Presentation (2 results)

  • [Presentation] マウス大腸癌肝転移モデルにおけるヒスタミンの転移抑制効果2014

    • Author(s)
      倉増敦朗、吉村清、井上萌子、玉田耕治、田中智之、前山一隆、乾誠
    • Organizer
      第67回日本薬理学会西南部会
    • Place of Presentation
      福岡県北九州市(産業医科大学)
    • Year and Date
      2014-11-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抗4-1BB抗体/抗PD-1抗体を用いた癌免疫療法2012

    • Author(s)
      新藤 芳太郎, 吉村 清, 倉増 敦朗, 渡邊 裕策, 前田 祥成, 鈴木 伸明, 吉野 茂文, 硲 彰一, 八木田 秀雄, 岡 正朗
    • Organizer
      第50回日本癌治療学会学術集会
    • Place of Presentation
      横浜 パシフィコ横浜
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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