Suppressive role of histamine in hepatic colorectal cancer matastasis

• Project/Area Number: 24590322
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Yamaguchi University
• Principal Investigator: KURAMASU Atsuo 山口大学, 医学(系)研究科(研究院), 准教授 (90302091)
• Co-Investigator(Kenkyū-buntansha): YOSHIMURA Kiyoshi 国立研究開発法人国立がん研究センター, 先端医療開発センター, 分野長 (30346564) ; TAMADA Koji 山口大学, 大学院医学系研究科, 教授 (00615841)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ヒスタミン / 大腸癌 / 肝転移 / 制御性T細胞 / ヒスチジン脱炭酸酵素 / 制御性Ｔ細胞 / ハイドロダイナミックインジェクション

Outline of Final Research Achievements

Role of histamine in hepatic colorectal cancer matastasis was investigated using mice deficient of endogenous histamine. In mouse hepatic colorectal cancer matastasis model, mice lacking histamine-synthesizing enzyme showed significantly shorter survival, suggesting that histamine had suppressive role in hepatic metastatis. In spleen and liver from histamine-deficient mice with hepatic metastasis, regulatory T cells were significantly increased, showing a possible mechanism of Treg-mediated suppression of anti-tumor immune response.

Research Products

• [Presentation] マウス大腸癌肝転移モデルにおけるヒスタミンの転移抑制効果 (2014)
  • Author(s): 倉増敦朗、吉村清、井上萌子、玉田耕治、田中智之、前山一隆、乾誠
  • Organizer: 第67回日本薬理学会西南部会
  • Place of Presentation: 福岡県北九州市（産業医科大学）
  • Year and Date: 2014-11-23
• [Presentation] 抗4-1BB抗体/抗PD-1抗体を用いた癌免疫療法 (2012)
  • Author(s): 新藤 芳太郎, 吉村 清, 倉増 敦朗, 渡邊 裕策, 前田 祥成, 鈴木 伸明, 吉野 茂文, 硲 彰一, 八木田 秀雄, 岡 正朗
  • Organizer: 第５０回日本癌治療学会学術集会
  • Place of Presentation: 横浜 パシフィコ横浜