Suppressive role of histamine in hepatic colorectal cancer matastasis
Project/Area Number |
24590322
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General pharmacology
|
Research Institution | Yamaguchi University |
Principal Investigator |
KURAMASU Atsuo 山口大学, 医学(系)研究科(研究院), 准教授 (90302091)
|
Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Kiyoshi 国立研究開発法人国立がん研究センター, 先端医療開発センター, 分野長 (30346564)
TAMADA Koji 山口大学, 大学院医学系研究科, 教授 (00615841)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | ヒスタミン / 大腸癌 / 肝転移 / 制御性T細胞 / ヒスチジン脱炭酸酵素 / 制御性T細胞 / ハイドロダイナミックインジェクション |
Outline of Final Research Achievements |
Role of histamine in hepatic colorectal cancer matastasis was investigated using mice deficient of endogenous histamine. In mouse hepatic colorectal cancer matastasis model, mice lacking histamine-synthesizing enzyme showed significantly shorter survival, suggesting that histamine had suppressive role in hepatic metastatis. In spleen and liver from histamine-deficient mice with hepatic metastasis, regulatory T cells were significantly increased, showing a possible mechanism of Treg-mediated suppression of anti-tumor immune response.
|
Report
(4 results)
Research Products
(2 results)