Mechanisms for the intracellular calcium dependent automaticity in the pulmonary-vein myocardium
| Project/Area Number |
24590334
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 肺静脈心筋 / 活動電位 / 細胞内カルシウム / 心房細動 / 筋小胞体 |
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| Outline of Final Research Achievements |
Intracellular Ca2+-dependent electrical activity was observed in the isolated pulmonary-vein myocardium from small experimental animals, guinea-pig, rat and mouse. The activity was constant in the guinea-pig while intermittent in the rat and mouse. Intracellular Ca2+ released from the sarcoplasmic reticulum through the ryanodine receptor or the IP3 receptor causes a depolarization when pumped out of the cell by the sodium-calcium exchanger, which triggers the firing of the action potential. The electrical activity was induced by alpha- or beta-adrenergic receptor stimulation, and was inhibited by muscarinic receptor stimulation. Thus, it appears possible to control the pulmonary-vein automaticity through pharmacologica modification of intracellular Ca2+ dynamics and autonomic nerve influence.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses.2014
Author(s)
Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y
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Journal Title
J Clin Invest.
Volume: 124
Issue: 6
Pages: 2785-2801
DOI
Related Report
Peer Reviewed / Open Access
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