Mechanistic and therapeutic investigation of the outside fibroblasts involving the inner neointima formation after implantation of PTFE grafts.
| Project/Area Number |
24590336
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
JIN DENAN 大阪医科大学, 医学部, 講師 (90319533)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAI Shinji 大阪医科大学, 医学部, 准教授 (80288703)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | PTFE / 人工血管 / 内腔狭窄 / キマーゼ / キマーゼ阻害薬 / 内膜肥厚 / イヌ / 線維芽細胞 / 遊走 / 国際情報交換 |
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| Outline of Final Research Achievements |
The most common way to provide vascular access for hemodialysis in patients is to either create a native arteriovenous (AV) fistula or to graft an artificial vessel made by polytetrafluoroethylene (PTFE) between a native artery and vein in a clinical setting. However, the creation of a native AV fistula is often restricted due to the lack of suitable vascular sites in patients with end-stage renal disease. Thus, the AV graft currently accounts for the majority of vascular access routes in hemodialysis patients. Unfortunately, in most cases, patency of the AV graft as vascular access route is often less than 2 years. Therefore, not only the economic costs for this type of treatment, but also the need for surgical revision to correct the poor patency rate in hemodialysis patients has become a very big problem.
In this report, we will introduce our attempts for the treatment of vascular access failure in the dog AV graft models by using pharmacological and physical fashions.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte spoptosis.2012
Author(s)
Matsuno K, Iwata K, Matsumoto M, Katsuyama M, Cui W, Murata A, Nakamura H, Ibi M, Ikami K, Zhang J, Matoba S, Jin D, Takai S, Matsubara H, Matsuda N, Yabe-Nishimura C
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Journal Title
Free Radic Biol Med
Volume: 53
Issue: 9
Pages: 1718-1728
DOI
Related Report
Peer Reviewed
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