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Mechanistic and therapeutic investigation of the outside fibroblasts involving the inner neointima formation after implantation of PTFE grafts.

Research Project

Project/Area Number 24590336
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General pharmacology
Research InstitutionOsaka Medical College

Principal Investigator

JIN DENAN  大阪医科大学, 医学部, 講師 (90319533)

Co-Investigator(Renkei-kenkyūsha) TAKAI Shinji  大阪医科大学, 医学部, 准教授 (80288703)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsPTFE / 人工血管 / 内腔狭窄 / キマーゼ / キマーゼ阻害薬 / 内膜肥厚 / イヌ / 線維芽細胞 / 遊走 / 国際情報交換
Outline of Final Research Achievements

The most common way to provide vascular access for hemodialysis in patients is to either create a native arteriovenous (AV) fistula or to graft an artificial vessel made by polytetrafluoroethylene (PTFE) between a native artery and vein in a clinical setting. However, the creation of a native AV fistula is often restricted due to the lack of suitable vascular sites in patients with end-stage renal disease. Thus, the AV graft currently accounts for the majority of vascular access routes in hemodialysis patients. Unfortunately, in most cases, patency of the AV graft as vascular access route is often less than 2 years. Therefore, not only the economic costs for this type of treatment, but also the need for surgical revision to correct the poor patency rate in hemodialysis patients has become a very big problem.
In this report, we will introduce our attempts for the treatment of vascular access failure in the dog AV graft models by using pharmacological and physical fashions.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (14 results)

All 2014 2013 2012

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (2 results)

  • [Journal Article] Significance of vascular dipeptidyl peptidase-4 inhibition on vascular protection in Zucker diabetic fatty rats.2014

    • Author(s)
      Takai S, Sakonjo H, Jin D.
    • Journal Title

      J Pharmacol Sci

      Volume: 125 Pages: 386-393

    • NAID

      130004677797

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats.2014

    • Author(s)
      Takai S, Jin D, Chen H, Li W, Yamamoto H, Yamanishi K, Miyazaki M, Higashino H, Yamanishi H, Okamura H.
    • Journal Title

      J Hypertens

      Volume: 32 Issue: 8 Pages: 1637-1648

    • DOI

      10.1097/hjh.0000000000000231

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chymase inhibition attenuates lipopolysaccharide/ d-galactosamine-induced acute liver failure in hamsters2013

    • Author(s)
      Imai Y, Takai S, Jin D, Komeda K, Tashiro K, Li ZL, Otsuki Y, Okamura H, Hayashi M, Uchiyama K.
    • Journal Title

      Pharmacology

      Volume: 40 Issue: 1-2 Pages: 832-840

    • DOI

      10.1159/000357684

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of the vascular concentration of angiotensin II-receptor blockers on the mechanism of lowering blood pressure in spontaneously hypertensive rats.2013

    • Author(s)
      Takai S, Jin D, Sakonjo H, Takubo T, Nakanishi T.
    • Journal Title

      J Pharmacol Sci.

      Volume: 123 Pages: 371-379

    • NAID

      130003382617

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significance of matrix metalloproteinase-9 inhibition by imidapril for prevention of abdominal aortic aneurysms in angiotensin II type 1 receptor-knockout mice.2013

    • Author(s)
      Takai S, Jin D, Yamamoto D, Li ZL, Otsuki Y, Miyazaki M.
    • Journal Title

      J Pharmacol Sci.

      Volume: 123 Pages: 185-194

    • NAID

      130003382588

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chymase inhibition attenuates monocrotaline-induced sinusoidal obstruction syndrome in hamsters.2013

    • Author(s)
      Masubuchi S, Komeda K, Takai S, Jin D, Tashiro K, Li ZL, Otsuki Y, Okamura H, Hayashi M, Uchiyama K
    • Journal Title

      Curr Med Chem

      Volume: 20 Pages: 2723-2729

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chymase inhibitor ameliorates hepatic steatosis and fibrosis on established non-alcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet.2013

    • Author(s)
      Masubuchi S, Takai S, Jin D, Tashiro K, Komeda K, Li ZL, Otsuki Y, Okamura H, Hayashi M, Uchiyama K.
    • Journal Title

      Hepatol Res

      Volume: 印刷中 Issue: 9 Pages: 970-978

    • DOI

      10.1111/hepr.12042

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Powerful vascular protection by combining cilnidipine with valsartan in stroke-prone, spontaneously hypertensive rats.2013

    • Author(s)
      Takai S, Jin D, Aritomi S, Niinuma K, Miyazaki M.
    • Journal Title

      Hypertens Res

      Volume: 36 Issue: 4 Pages: 342-348

    • DOI

      10.1038/hr.2012.187

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II promotes aortic valve thickening independent of elevated blood pressure I apolipoprotein-E deficientmice2013

    • Author(s)
      Tomohiro Fujisaka,Toshiaki Hanafusa,Nobukazu Ishizaka
    • Journal Title

      Atherosclerosis

      Volume: 226(1) Issue: 1 Pages: 82-7

    • DOI

      10.1016/j.atherosclerosis.2012.10.055

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte spoptosis.2012

    • Author(s)
      Matsuno K, Iwata K, Matsumoto M, Katsuyama M, Cui W, Murata A, Nakamura H, Ibi M, Ikami K, Zhang J, Matoba S, Jin D, Takai S, Matsubara H, Matsuda N, Yabe-Nishimura C
    • Journal Title

      Free Radic Biol Med

      Volume: 53 Issue: 9 Pages: 1718-1728

    • DOI

      10.1016/j.freeradbiomed.2012.08.590

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Outside fibroblasts play a key role in the development of inner neointima after the implantation of polytetrafluoroethylene grafts.2012

    • Author(s)
      Jin D, Takai S, Li Z, Sakonjo H, Otsuki Y, Shibayama Y, Miyazaki M.
    • Journal Title

      J Pharmacol Sci.

      Volume: 119 Pages: 139-149

    • NAID

      10030828453

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multiple mechanisms for the action of chymase inhibitors.2012

    • Author(s)
      Takai S, Jin D, Miyazaki M.
    • Journal Title

      J Pharmacol Sci.

      Volume: 118 Pages: 311-316

    • NAID

      10030455328

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] PTFE人工血管移植後の血管周囲線維芽細胞の遊走とその管腔内内膜肥厚の形成2013

    • Author(s)
      金 徳男、高井 真司、宮崎 瑞夫
    • Organizer
      第42回日本心脈管作動物質学会
    • Place of Presentation
      奈良県新公会堂(奈良県)
    • Related Report
      2012 Research-status Report
  • [Presentation] PTFE人工血管移植後の血管内膜肥厚における外膜側線維芽細胞の役割2013

    • Author(s)
      金 徳男、高井 真司、宮崎 瑞夫
    • Organizer
      第86回 日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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