| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
In severely damaged livers where hepatocyte proliferation is impaired, facultative liver stem/progenitor cells (LPCs) proliferate and are considered to contribute to the regenerative process. We sought to elucidate the detailed underlying mechanisms for LPC regulation as well as those connecting the LPC response and liver pathologies such as fibrosis and tumorigenesis, by focusing on the intercellular signaling network involving FGF7. We have newly identified several molecules that play critical roles in LPC regulation, including extracellular signals and a transcription factor. We have also found a cell population that coordinately regulates both the LPC induction and fibrogenic response, thereby revealing a part of the mechanisms linking these two cellular responses in injured liver.
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