| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Hypoxic response plays an important role to maintain homeostasis under hypoxic condition. HIF is a transcription factor which has a central role during hypoxic response. I have identified that the activity of HIF becomes decreased in the chronic phase of hypoxia.
In this study, we tried to identify and characterize the transcription factor(s) which will substitute HIF during the chronic phase. As a result, we identified CREB and NF-κB as such molecules. Further, these factors had a critical role to regulate the tumor metastasis in a mouse transplantation model.
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