| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Wnt signaling pathway plays an important role in cancer and embryonic development, a key feature of Wnt signaling activation is beta-catenin nuclear translocation.
In this study, we first identified IQGAP1 as a scaffold protein that binds DVL, one of Wnt signaling molecules. Then we analyzed the function of IQGAP1 in Wnt signaling pathway.
As a result, (1) IQGAP1 functioned as a positive regulator of Wnt signaling. (2) IQGAP1 complexed with beta-catenin and DVL2. (3) IQGAP1 was capable to bind with Importin-beta5 and Ran so that the above complex translocated into the nucleus.
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