Functional characterization of epigenetic regulatory factors identified by retroviral insertional mutagenesis
| Project/Area Number |
24590346
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
SUZUKI TAKESHI 金沢大学, がん進展制御研究所, 教授 (30262075)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | エピジェネティクス / がん遺伝子 / レトロウイルス / 分子標的 / 挿入変異 / がん分子標的 / 疾患モデルマウス |
|---|
| Outline of Final Research Achievements |
Retroviral insertional mutagenesis in mice is one of the powerful strategies for high-throughput identification of cancer genes. Using this system, we have frequently identified the genes encoding the enzymes engaged in histone or DNA methylation. We have found that some of the enzymes are involved not only in the tumor initiation but also in the malignant tumor progression such as cell invasion and drug resistance.
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Report
(4 results)
Research Products
(21 results)
