Research Project
Grant-in-Aid for Scientific Research (C)
Steroidogenic factor 1 (SF-1, also known as Ad4BP) plays a pivotal role in the regulation of expression of steroidogenesis-related genes. To identify novel SF-1-target genes, a genome-wide analysis was carried out. We found that human glutathione S-transferase A (GSTA) family genes (hGSTA1–4) are regulated by SF-1. All hGSTA genes were upregulated by transduction of SF-1 into hMSCs, while knockdown of endogenous SF-1 in H295R cells downregulated all hGSTA genes. ChIP and 3C assays revealed that the coordinated expression of the genes was based on changes in higher-order chromatin structure triggered by SF-1. In steroidogenesis, the gene products of hGSTA1 and hGSTA3 were shown to function in a coordinated fashion with 3β-HSD II. This result indicates that enzymes hGSTA1-1 and hGSTA3-3 could be considered new members of the group of SF-1 controlled steroidogenic enzymes and to participate in Δ5-Δ4 isomerization of steroid hormone precursors.
All 2015 2014 2013 2012
All Journal Article (11 results) (of which Peer Reviewed: 10 results, Acknowledgement Compliant: 2 results, Open Access: 1 results) Presentation (53 results) (of which Invited: 4 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)
Molecular and Cellular Endocrinology
Volume: 408 Pages: 133-137
10.1016/j.mce.2014.11.019
Biochem. J.
Volume: 460 Issue: 3 Pages: 459-471
10.1042/bj20131522
Biochim Biophys Acta.
Volume: 1839 Issue: 5 Pages: 406-14
10.1016/j.bbagrm.2014.03.016
Volume: 1839 Issue: 1 Pages: 33-42
10.1016/j.bbagrm.2013.11.005
Endocrinology
Volume: 154 Issue: 8 Pages: 2870-2880
10.1210/en.2012-2173
FASEB J
Volume: 27 Issue: 8 Pages: 3198-3208
10.1096/fj.12-222745
Volume: 369 Issue: 1-2 Pages: 42-51
10.1016/j.mce.2013.02.004
Volume: 154(4） Issue: 4 Pages: 1648-1660
10.1210/en.2012-2008
Volume: 370 Issue: 1-2 Pages: 1-10
10.1016/j.mce.2013.02.012
日本生殖内分泌学会雑誌
Volume: 17 Pages: 11-16
40019434125
Volume: 153 Issue: 11 Pages: 5522-5534
10.1210/en.2012-1334
