| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Alzheimer's disease (AD) is characterized by cerebral amyloid plaques, which are formed by extracellular accumulation of amyloid beta peptides. Heparan sulfate is an extracellular sugar chain found in amyloid plaques in the brain of transgenic AD mouse models and patients with AD. Heparan sulfate subdomains abundant in amyloid plaques of AD mouse brain sections were substantially degraded by Sulf-2, an extracellular endosulfatase. Ectopic expression of Sulf-2 facilitated amyloid clearance mediated by phagocytotic cells, which were cultured with AD mouse brain sections in an ex vivo phagocytosis assay. These results suggest that AD pathogenesis could be regulated by an enzymatic remodeling of extracellular heparan sulfate in AD brains.
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