Elucidation of tumor suppresive role of mammalian Mitotic Exit Network
| Project/Area Number |
24590360
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Mitotic Exit Network / LATS1 / MYPT1 / PLK1 / APC/C / CDC26 / Mitotic exit network / Lats1 / mitotic exit network |
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| Outline of Final Research Achievements |
Recent advance of knock out mice study has focused on the importance of Cdk1 on cell cycle progression. However, our understanding of Cdk1 regulation is still limited compared with that of yeast Cdk1. We carried out this project to reveal the significance and signaling mechanism of mammalian MEN (mitotic exit network), one of the Cdk1 regulatory signaling cascade originally found in budding yeast. Although each component of MEN is highly conserved to human, our data strongly suggest signaling of mammalian MEN (e.g. downstream target) is somewhat different from that of the yeast one. Further analysis will be required to elucidate the content of this difference.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C.2015
Author(s)
Masuda K, Chiyoda T, Sugiyama N, Segura-Cabrera A, Kabe Y, Ueki A, Banno K, Suematsu M, Aoki D, Ishihama Y, Saya H, Kuninaka S
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Journal Title
PLoS One
Volume: 10
Issue: 2
Pages: 1-22
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Twist2 functions as a tumor suppressor in murine osteosarcoma cells.2013
Author(s)
Ishikawa T, Shimizu T, Ueki A, Yamaguchi S, Onishi N, Sugihara E, Kuninaka S, Miyamoto T, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Mabuchi Y, Matsuzaki Y, Yamaguchi R, Miyano S and Saya H
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Journal Title
Cancer Sci
Volume: (in press)
Issue: 7
Pages: 880-888
DOI
Related Report
Peer Reviewed
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