GATA factor-mediated maintenance of renal function
Project/Area Number |
24590371
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathological medical chemistry
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Research Institution | Tohoku Medical and Pharmaceutical University (2016) Tohoku University (2012-2015) |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
MORITO Naoki 筑波大学, 医学医療系, 講師 (70463825)
ABE Michiaki 東北大学, 大学病院, 講師 (40400246)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | メサンギウム細胞 / 腎臓病 / 虚血再還流障害 / GATA因子 / 尿細管 / GATA3 / トランスジェニックマウス / 糸球体腎炎 / 炎症性サイトカイン / GATA転写因子 / 腎集合管細胞 / マクロファージ / GATA2 / 腎集合管 / アクアポリン / 虚血再還流 |
Outline of Final Research Achievements |
We demonstrated that zinc finger transcription factors,i.e., GATA2 and GATA3 is specifically expressed in renal collecting duct cells and glomerular mesangial cells, respectively. GATA3 plays a critical role for maintenance of the glomerular mesangial cells. Hence, GATA3-deficiency led to the occurence of spontaneous glomerulonephritis. GATA2 regulates a series of genes involved in water-reabsorption. Therefore, renal tubular cell-specific GATA2-deficient mice exhibited higher amount of urine. GATA2 also participates in the regulation of induced expression of inflammatory cytokine genes in the diseased kidney. The renal tubular cell-specific GATA2-deficient mice showed reduced expression level of the inflammatory cytokine genes and resistance against acute kidney injury. Furthermore, a newly identified GATA-inhibitor nicely ameliorated renal damages in the diseased kidney. Collectively, we propose that GATA2 can be a potential therapeutic target for the inflammatory kidney diseases.
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Report
(5 results)
Research Products
(44 results)
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[Journal Article] NRF2 intensifies host defense systems to prevent lung carcinogenesis, but after tumor initiation accelerates malignant cell growth.2016
Author(s)
Satoh H, Moriguchi T, Saigusa D, Baird L, Yu L, Rokutan H, Igarashi K, Ebina M, Shibata T, Yamamoto M.
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Journal Title
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation.2015
Author(s)
Nadine Keleku-Lukwete, Mikiko Suzuki, Akihito Otsuki, Kouhei Tsuchida, Saori Katayama, Makiko Hayashi, Eriko Naganuma, Takashi Moriguchi, Osamu Tanabe, James Douglas Engel, Masue Imaizumi, Masayuki Yamamoto
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Journal Title
Proc Natl Acad Sci U S A
Volume: 112
Issue: 39
Pages: 12169-12174
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] MafB promotes atherosclerosis by inhibiting foam-cell apoptosis2014
Author(s)
Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonz P, Takahashi S
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Journal Title
Nat Commun
Volume: 5
Issue: 1
Pages: 3147-3147
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation2013
Author(s)
Suzuki M, Kobayashi-Osaki M, Tsutsumi S, Pan X, Ohmori S, Takai J, Moriguchi T, Ohneda O, Ohneda K, Shimizu R, Kanki Y, Kodama T, Aburatani H, Yamamoto M
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Journal Title
Genes Cells
Volume: 18
Issue: 11
Pages: 921-933
DOI
Related Report
Peer Reviewed
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[Journal Article] Establishment of erythroleukemic GAK14 cells and characterization of GATA1 N-terminal domain2013
Author(s)
Mukai HY, Suzuki M, Nagano M, Ohmori S, Otsuki A, Tsuchida K, Moriguchi T, Ohneda K, Shimizu R, Ohneda O, Yamamoto M,
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Journal Title
Genes Cells
Volume: 18
Issue: 10
Pages: 886-898
DOI
Related Report
Peer Reviewed
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[Journal Article] Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regul ation of GATA32013
Author(s)
Akiyama Y, Kikuchi K, Saigusa D, Suzuki T, Takeuchi Y, Mishima E, Yamamoto Y, Ishida A, Sugawara D, Jinno D, Shima H, Toyohara T, Suzuki C, Souma T, Moriguchi T, Tomioka Y, Ito S, Abe T.
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Journal Title
PLoS One
Volume: 8
Issue: 7
Pages: e66518-e66518
DOI
Related Report
Peer Reviewed
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[Journal Article] Plasticity of renal erythropoietin-producing cells governs fibrosis2013
Author(s)
Souma T, Yamazaki S, Moriguchi T, Suzuki N, Hirano I, Pan X, Minegishi N, Abe M, Kiyomoto H, Ito S, Yamamoto M
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Journal Title
J Am Soc Nephrol
Volume: 24
Issue: 10
Pages: 1599-1616
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.2013
Author(s)
Eba S, Hoshikawa Y, Moriguchi T, Mitsuishi Y, Satoh H, Ishida K, Watanabe T, Shimizu T, Shimokawa H, Okada Y, Yamamoto M, Kondo T
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Journal Title
Am J Respir Cell Mol Biol
Volume: 49(2
Issue: 2
Pages: 324-333
DOI
Related Report
Peer Reviewed
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[Journal Article] UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice2012
Author(s)
Ainoya K, Moriguchi T, Ohmori S, Souma T, Takai J, Morita M, Chandler KJ, Mortlock DP, Shimizu R, Engel JD, Lim KC, Yamamoto M.
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Journal Title
Molecular and Cellular Biology
Volume: 32
Issue: 12
Pages: 2312-2322
DOI
Related Report
Peer Reviewed
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[Journal Article] Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation2012
Author(s)
Xue M, Rabbani N, Momiji H, Imbasi P, Anwar MM, Kitteringham N, Park BK, Souma T, Moriguchi T, Yamamoto M, Thornalley PJ.
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Journal Title
Biochemical Journal
Volume: 443
Issue: 1
Pages: 213-222
DOI
Related Report
Peer Reviewed
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