Molecular mechanism of the spontaneous regression of neuroblastoma
| Project/Area Number |
24590372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
INOUE Jun 東京医科歯科大学, 難治疾患研究所, 講師 (50568326)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経芽腫 / 自然退縮 / 細胞死 |
|---|
| Outline of Final Research Achievements |
The molecular mechanism of spontaneous regression of neuroblastoma (NB) is largely unknown. I have previously demonstrated that the cell death mediated by accumulation of LAPTM5 protein might be closely associated with this event. However, it is unclear for its physiological significance. With the support of this grant, I clarified the mechanism to regulate LAPTM5 expression and induction of cell death. These findings may be valuable knowledge for understanding of molecular mechanism for tumor regression, as well as development of new therapeutic strategy.
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Report
(4 results)
Research Products
(13 results)
