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Molecular mechanism of the spontaneous regression of neuroblastoma

Research Project

Project/Area Number 24590372
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathological medical chemistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

INOUE Jun  東京医科歯科大学, 難治疾患研究所, 講師 (50568326)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords神経芽腫 / 自然退縮 / 細胞死
Outline of Final Research Achievements

The molecular mechanism of spontaneous regression of neuroblastoma (NB) is largely unknown. I have previously demonstrated that the cell death mediated by accumulation of LAPTM5 protein might be closely associated with this event. However, it is unclear for its physiological significance. With the support of this grant, I clarified the mechanism to regulate LAPTM5 expression and induction of cell death. These findings may be valuable knowledge for understanding of molecular mechanism for tumor regression, as well as development of new therapeutic strategy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] High Expression of SQSTM1/p62 Protein Is Associated with Poor Prognosis in Epithelial Ovarian Cancer2014

    • Author(s)
      Iwadate R, Inoue J, Tsuda H, Takano M, Furuya K, Hirasawa A, Aoki D, Inazawa J
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 47 Issue: 6 Pages: 295-301

    • DOI

      10.1267/ahc.14048

    • NAID

      130004902927

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] γ-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors.2014

    • Author(s)
      Takemura K, Inazawa J, et al.
    • Journal Title

      Hum Pathol.

      Volume: 45 Issue: 2 Pages: 331-41

    • DOI

      10.1016/j.humpath.2013.09.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of miRNA-based molecular diagnostics and treatment of NRF2-stabilized tumors.2014

    • Author(s)
      Yamamoto S, Inazawa J, et al.
    • Journal Title

      Mol Cancer Res.

      Volume: 12 Issue: 1 Pages: 58-68

    • DOI

      10.1158/1541-7786.mcr-13-0246-t

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A transcriptional variant of the LC3A gene is involved in autophagy and frequently inactivated in human cancers2012

    • Author(s)
      Bai H, Inazawa J, et al
    • Journal Title

      Oncogene

      Volume: (Epub ahead of print) Issue: 40 Pages: 4397-408

    • DOI

      10.1038/onc.2011.613

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 食道癌におけるLAPTM5の不活性化2014

    • Author(s)
      ヌイラン・ミッシェル、井上純、河野辰幸、稲澤譲治
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜・パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] マイクロRNAを基盤としたNRF2活性化癌に対する診断・治療法の確立2014

    • Author(s)
      井上純、山本信祐、藤原直人、河野辰幸、小村健、小崎健一、稲澤譲治
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜・パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] p62/SQSTM1タンパク質の高発現は子宮体癌の悪性形質および不良な予後と相関する2014

    • Author(s)
      岩舘怜子、井上純、津田均、平沢晃、青木大輔、稲澤譲治
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜・パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新規癌抑制性microRNAとしてのMir-634の同定2014

    • Author(s)
      藤原直人、井上純、河野辰幸、小崎健一、稲澤譲治
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜・パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] マイクロRNAを基盤としたNRF2活性化癌に対する診断・治療法の確立2014

    • Author(s)
      井上純、稲澤譲治
    • Organizer
      第18回日本がん分子標的治療学会学術集会
    • Place of Presentation
      仙台市情報産業プラザ
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Assessment of autophagy status for cancer therapy2013

    • Author(s)
      井上 純、稲澤譲治
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒト癌におけるオートファジー関連遺伝子の異常2012

    • Author(s)
      井上 純、稲澤讓治
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      さっぽろ芸文館 北海道
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] マイクロRNAの測定方法、並びに、がん治療剤及びこれを含有するがん治療のための医薬組成物2014

    • Inventor(s)
      井上純、山本信祐、河野辰幸、小崎健一、稲澤譲治
    • Industrial Property Rights Holder
      井上純、山本信祐、河野辰幸、小崎健一、稲澤譲治
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-02-17
    • Related Report
      2013 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 神経芽腫の検出方法2012

    • Inventor(s)
      稲澤譲治・井本逸勢・井上 純
    • Industrial Property Rights Holder
      稲澤譲治・井本逸勢・井上 純
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-07-10
    • Related Report
      2012 Research-status Report
    • Overseas

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Published: 2013-05-31   Modified: 2019-07-29  

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