Analyses of molecular mechanism for regulating gene expression of anti-inflammatory NLR family member PYNOD
| Project/Area Number |
24590374
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
IMAMURA Ryu 金沢大学, がん進展制御研究所, 助教 (10311680)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | NLRファミリー / 自然免疫 / PYNOD / 胃がん / 遺伝子発現 / NLRファミリー蛋白 |
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| Outline of Final Research Achievements |
Many members of the nucleotide-binding and oligomerization domain (NOD) and leucine-rich-repeat (LRR)-containing protein (NLR) family play important roles in pathogen recognition and inflammation. We identified PYNOD/NLRP10, one of the member of this family that lacks LRR, and found that PYNOD inhibit inflammatory signal mediated by caspase-1 and ASC. To further investigate physiological function of PYNOD, we have established PYNOD-deficient mice. PYNOD-deficient mice exhibited no obvious gross abnormalities, no evidence of autoimmunity and spontaneous tumor formation, and normal innate immune responses.
However, we have found that PYNOD is highly expressed in stomach of gastric cancer mouse model (Gan mice), in which inflammatory COX-2/PGE2 pathway and Wnt signaling are activated simultaneously in gastric mucosa. Furthermore, we also detected high PYNOD expression in tumor region containing papillary type adenocarcinoma from gastric cancer patients.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Pyropotic cells externalize eat-me and release find-me signals and efficiently engulfed by macrophages.2013
Author(s)
Wang, Q., Imamura, R., Motani, K., Kushiyama, H., Nagata, S. and Suda, T.
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Journal Title
Int. Immunol.
Volume: 25
Pages: 363-372
DOI
Related Report
Peer Reviewed
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[Journal Article] Fas ligand has a greater impact than TNF-alpha on apoptosis and inflammation in ischemic acute kidney injury.2012
Author(s)
Furuichi K, Kokubo S, Hara A, Imamura R, Wang Q, Kitajima S, Toyama T, Okumura T, Matsushima K, Suda T, Mukaida N, Kaneko S, Wada T
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Journal Title
Nephron Extra
Volume: 2
Pages: 27-38
DOI
Related Report
Peer Reviewed
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[Presentation] Migration of skin antigen-transporting cells in PYNOD-deficient mice.2014
Author(s)
Yoshino, M., Imamura, R., Murata, A., Shimoda, Y., Hikosaka, M., Suda, T., and Hayashi, S.
Organizer
第43回日本免疫学会総会・学術集会
Place of Presentation
国立京都国際会館 (京都)
Year and Date
2014-12-10
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