| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Tumor development is driven not only by the alterations in the genome of cancer cells itself but also by the surrounding microenvironment that supplies factors crucial for their growth and survival. Although it is known that phospholipase Cε (PLCε), an effector of Ras and Rap small GTPases, plays an important role in tumor development through augmenting cancer-associated inflammation in the tumor microenvironment, the molecular mechanism by which PLCε-mediated tumor development is not fully understood. This research shows that PLCε mediates signals that upregulates proinflammatory gene transcription through prolongation of IκB inactivation. It shows that the survival of cells overexpressing the mutationally-activated H-Ras in vitro is affected by the supply of zinc ions and glucose, both of which are known to be supplied from the microenvironment in vivo.
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