Insuffcient function of ARID1A in tumor.

• Project/Area Number: 24590384
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Gifu University
• Principal Investigator: TAKEUCHI Tamotsu 岐阜大学, 医学(系)研究科(研究院), 教授 (50226990)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: SWI/SNF / chromatin / ARID1A / TMEM207 / cutaneous adnexal tumor / クロマチン再構成因子複合体 / 癌 / ras / 発がん / モデルマウス

Outline of Final Research Achievements

TMEM207 was first characterized as being an important molecule for the invasion activity of gastric signet-ring cell carcinoma cells and later shown to be associated with insufficient expression of ARID1A, a DNA-binding motif of chromatin remodeling complez, human SWI/SNF. In order to unravel the pathological properties of TMEM207, we generated several transgenic mouse lines, , in which murine TMEM207 was ectopically expressed under a truncated (by 200 bp) proximal promoter of the murine intestinal trefoil factor (ITF) gene. Notably, a C57BL/6-Tg (ITF-TMEM207) mouse line exhibited a high incidence of spontaneous intradermal tumors with histopathological features that resembled those of various human cutaneous adnexal tumors. In addition, we also observed cutaneous adnexal tumors in three other C57BL/6-Tg (ITF-TMEM207) transgenic mouse lines.

Research Products

• [Journal Article] Expression of ZNF396 in basal cell carcinoma. (2014)
  • Author(s): Bai J, Kito Y, Okubo H, Nagayama T, Takeuchi T.
  • Journal Title: Arch Dermatol Res. Volume: 印刷中 Issue: 4 Pages: 399-404
  • DOI: 10.1007/s00403-014-1442-1
  • Peer Reviewed
• [Journal Article] Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma. (2014)
  • Author(s): Kito Y, Bai J, Goto N, Okubo H, Adachi Y, Nagayama T, Takeuchi T.
  • Journal Title: Int J Exp Pathol. Volume: 95 Issue: 1 Pages: 24-28
  • DOI: 10.1111/iep.12051
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Transgenic mouse model of cutaneous adnexal tumors. (2014)
  • Author(s): KIto Y, Saigo C, Kurabayashi A, Furihata M, Takeuchi T.
  • Journal Title: Dis Model Mech. Volume: 7 Pages: 1379-1383
  • DOI: 10.1242/dmm.017574
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Is it possible to diagnose malignancy from fluid in cystic ovarian tumors? (2013)
  • Author(s): Yamada R, Maeda N, Oguri H, Adachi Y, Takeuchi T, Furihata M, Fukaya T.
  • Journal Title: Eur J Obstet Gynecol Reprod Biol. Volume: 171 Issue: 1 Pages: 96-100
  • DOI: 10.1016/j.ejogrb.2013.08.003
  • Peer Reviewed
• [Journal Article] Mantle cell lymphoma with a unique pattern of CD5 expression: a case report with review of the literatures. (2013)
  • Author(s): Yamada T, Goto N, Tsurumi H, Takata K, Sato Y, Yoshino T, Moriwaki H, Kito Y, Takeuchi T, Iwata H.
  • Journal Title: Med Mol Morphol Volume: 印刷中 Issue: 3 Pages: 169-175
  • DOI: 10.1007/s00795-013-0060-x
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy as new treatment for clear cell sarcoma: Trial on different animal model. (2013)
  • Author(s): Andoh T, Fujimoto T, Sudo T, Suzuki M, Sakurai Y, Sakuma T, Moritake H, Sugimoto T, Takeuchi T, Sonobe H, Epstein AL, Fukumori Y, Ono K, Ichikawa H.
  • Journal Title: Appl Radiat Isot. Volume: 印刷中 Pages: 59-63
  • DOI: 10.1016/j.apradiso.2013.12.007
  • Peer Reviewed
• [Journal Article] A20 (TNFAIP3) Deletion in Epstein-Barr Virus-Associated Lymphoproliferative Disorders/Lymphomas. (2013)
  • Author(s): Ando M, Sato Y, Takata K, Nomoto J, Nakamura S, Ohshima K, Takeuchi T, Orita Y, Kobayashi Y, Yoshino T.
  • Journal Title: PLoS One. Volume: 8
  • NAID: 120005359115
  • Peer Reviewed
• [Journal Article] B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma without mediastinal disease: mimicking nodular sclerosis classical Hodgkin lymphoma. (2013)
  • Author(s): Iwaki N, Sato Y, Kurokawa T, Maeda Y, Ohno K, Takeuchi M, Takata K, Orita Y, Nakao S, Yoshino T.
  • Journal Title: Med Mol Morphol. Volume: In press
  • Peer Reviewed
• [Journal Article] Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation. (2012)
  • Author(s): Yasukawa T, Bhatt S, Takeuchi T, Kawauchi J, Takahashi H, Tsutsui A, Muraoka T, Inoue M, Tsuda M, Kitajima S, Conaway RC, Conaway JW, Trainor PA, Aso T.
  • Journal Title: Cell Reports Volume: 2 Pages: 1129-1136
  • Peer Reviewed
• [Presentation] 濾胞性リンパ腫におけるクロマチン再構成複合体因子ARID1Aの発現異常 (2013)
  • Author(s): 後藤尚絵、佐藤康晴、高田尚良、鬼頭勇輔、吉野正、竹内保
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌