Insuffcient function of ARID1A in tumor.
Project/Area Number |
24590384
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathological medical chemistry
|
Research Institution | Gifu University |
Principal Investigator |
TAKEUCHI Tamotsu 岐阜大学, 医学(系)研究科(研究院), 教授 (50226990)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | SWI/SNF / chromatin / ARID1A / TMEM207 / cutaneous adnexal tumor / クロマチン再構成因子複合体 / 癌 / ras / 発がん / モデルマウス |
Outline of Final Research Achievements |
TMEM207 was first characterized as being an important molecule for the invasion activity of gastric signet-ring cell carcinoma cells and later shown to be associated with insufficient expression of ARID1A, a DNA-binding motif of chromatin remodeling complez, human SWI/SNF. In order to unravel the pathological properties of TMEM207, we generated several transgenic mouse lines, , in which murine TMEM207 was ectopically expressed under a truncated (by 200 bp) proximal promoter of the murine intestinal trefoil factor (ITF) gene. Notably, a C57BL/6-Tg (ITF-TMEM207) mouse line exhibited a high incidence of spontaneous intradermal tumors with histopathological features that resembled those of various human cutaneous adnexal tumors. In addition, we also observed cutaneous adnexal tumors in three other C57BL/6-Tg (ITF-TMEM207) transgenic mouse lines.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Boron neutron capture therapy as new treatment for clear cell sarcoma: Trial on different animal model.2013
Author(s)
Andoh T, Fujimoto T, Sudo T, Suzuki M, Sakurai Y, Sakuma T, Moritake H, Sugimoto T, Takeuchi T, Sonobe H, Epstein AL, Fukumori Y, Ono K, Ichikawa H.
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Journal Title
Appl Radiat Isot.
Volume: 印刷中
Pages: 59-63
DOI
Related Report
Peer Reviewed
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[Journal Article] B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma without mediastinal disease: mimicking nodular sclerosis classical Hodgkin lymphoma.2013
Author(s)
Iwaki N, Sato Y, Kurokawa T, Maeda Y, Ohno K, Takeuchi M, Takata K, Orita Y, Nakao S, Yoshino T.
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Journal Title
Med Mol Morphol.
Volume: In press
Related Report
Peer Reviewed
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[Journal Article] Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation.2012
Author(s)
Yasukawa T, Bhatt S, Takeuchi T, Kawauchi J, Takahashi H, Tsutsui A, Muraoka T, Inoue M, Tsuda M, Kitajima S, Conaway RC, Conaway JW, Trainor PA, Aso T.
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Journal Title
Cell Reports
Volume: 2
Pages: 1129-1136
Related Report
Peer Reviewed
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