Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Outline of Final Research Achievements |
TMEM207 was first characterized as being an important molecule for the invasion activity of gastric signet-ring cell carcinoma cells and later shown to be associated with insufficient expression of ARID1A, a DNA-binding motif of chromatin remodeling complez, human SWI/SNF. In order to unravel the pathological properties of TMEM207, we generated several transgenic mouse lines, , in which murine TMEM207 was ectopically expressed under a truncated (by 200 bp) proximal promoter of the murine intestinal trefoil factor (ITF) gene. Notably, a C57BL/6-Tg (ITF-TMEM207) mouse line exhibited a high incidence of spontaneous intradermal tumors with histopathological features that resembled those of various human cutaneous adnexal tumors. In addition, we also observed cutaneous adnexal tumors in three other C57BL/6-Tg (ITF-TMEM207) transgenic mouse lines.
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