Regulation of directional movement during leukocyte chemotaxis by cell polarity proteins
| Project/Area Number |
24590385
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
KAMAKURA Sachiko 九州大学, 医学(系)研究科(研究院), 助教 (80398081)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ケモタキシス / 好中球 / 細胞極性 / 白血球 |
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| Outline of Final Research Achievements |
Cell movement directed by a gradient of a diffusible chemoattractant is known as chemotaxis, which plays a vital role in developmental morphogenesis and immune responses. Neutrophilic leukocytes, crucial for host defense, move toward the source of chemoattractants, which are derived from invading microbes and/or produced by infected hosts, thereby arriving correctly at sites of infection for pathogen killing. Although neutrophil chemotaxis requires not only increased motility but also directional movement, molecular mechanisms for directionality control have remained largely unknown. We have shown that Inscuteable protein regulates directionality of chemotaxing neutrophils by tethering chemoattractant-elicited trimeric-Gi-protein signaling to an evolutionarily-conserved Par-polarity-protein complex.
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Report
(4 results)
Research Products
(10 results)
