The role of Leukotriene B4 receptor type 2 in skin barrier function.
Project/Area Number |
24590386
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathological medical chemistry
|
Research Institution | Juntendo University (2014) Kyushu University (2012-2013) |
Principal Investigator |
SAEKI KAZUKO 順天堂大学, 医学部, 准教授 (00553273)
|
Research Collaborator |
LIU Min
ISHII Yumiko
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 脂質 / GPCR / 皮膚 / Gタンパク質共役型受容体 / 生理活性脂質 |
Outline of Final Research Achievements |
Leukotriene B4 receptor type 2 (BLT2) is a G protein-coupled receptor (GPCR) highly expressed in epidermal keratinocytes. 12-HHT is a high affinity ligand for BLT2 and produced during blood coagulation in a COX/TxA2S-dependent manner. In this study, we found that 12-HHT/BLT2 axis promotes skin wound healing by accelerating keratinocyte migration. It has been known that aspirin, a COX inhibitor, delays skin wound healing, but the precise mechanisms were wholly unknown. We showed that the impairment of 12-HHT production by aspirin treatment delays wound healing. We also showed that topical application of synthetic BLT2 agonist accelerates skin wound healing in wild-type C57BL/6J mice and diabetic db/db mice. These results suggest the possible application of BLT2 agonist as a therapeutic agent to accelerate wound healing, particularly for intractable wounds, such as diabetic ulcers.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] 12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.2014
Author(s)
Liu M, Saeki K, Matsunobu T, Okuno T, Koga T, Sugimoto Y, Yokoyama C, Nakamizo S, Kabashima K, Narumiya S, Shimizu T, Yokomizo T
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Journal Title
J Exp Med
Volume: 211
Issue: 6
Pages: 1063-1078
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia.2013
Author(s)
Matsunaga Y., Fukuyama S., Okuno T., Sasaki F., Matsunobu T., Asai Y., Matsumoto K., Saeki K., Oike M., Sadamura Y., Machida K., Nakanishi Y., Kubo M., Yokomizo T., Inoue H.
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Journal Title
FASEB J.
Volume: 27
Issue: 8
Pages: 3306-3314
DOI
Related Report
Peer Reviewed
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