| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Leukotriene B4 receptor type 2 (BLT2) is a G protein-coupled receptor (GPCR) highly expressed in epidermal keratinocytes. 12-HHT is a high affinity ligand for BLT2 and produced during blood coagulation in a COX/TxA2S-dependent manner. In this study, we found that 12-HHT/BLT2 axis promotes skin wound healing by accelerating keratinocyte migration. It has been known that aspirin, a COX inhibitor, delays skin wound healing, but the precise mechanisms were wholly unknown. We showed that the impairment of 12-HHT production by aspirin treatment delays wound healing. We also showed that topical application of synthetic BLT2 agonist accelerates skin wound healing in wild-type C57BL/6J mice and diabetic db/db mice. These results suggest the possible application of BLT2 agonist as a therapeutic agent to accelerate wound healing, particularly for intractable wounds, such as diabetic ulcers.
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