| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The occurrence of sporadic breast cancers is involved in long-term exposure of estrogen, which induces DNA damages in the epithelial cells of mammary glands. Estrogen stimulation induced rigorous DNA damages in ganp-depleted MCF7, suggesting that these damages is asoociated with abnormal development of mammary glands in mammary-specific ganp-deficient mice. GANP may be a tumor suppressive factor in mammary gland epithelia. Accordingly, it has been proved that low expression of GANP is an indicator of poor patients' prognosis in sporadic breast cancers.
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