The mechanisms of quinolinic acid-induced infiltration of reactive astrocytes and the amyloid beta peptide production in the activated glial cells
| Project/Area Number |
24590397
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
TAKIKAWA Osamu 独立行政法人国立長寿医療研究センター, 治療薬探索研究部, 室長 (70163342)
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| Co-Investigator(Kenkyū-buntansha) |
OKUNO Alato 独立行政法人国立長寿医療研究センター, 長寿医療研究センター・ラジオアイソトープ管理室, 特任研究員 (50623980)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アルツハイマー病 / トリプトファン代謝 / アミロイドβペプチド / キノリン酸 / 神経毒 / IDO / ＩＤＯ |
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| Outline of Final Research Achievements |
Alzheimer's disease (AD) is an increasing neurodegenerative disease and prevention and treatment of AD is an urgent social issue. Amyloid β peptide (Aβ) deposition is a well-known pathological feature in AD brains. A neurotoxin quinolinic acid (QA) has recently been to be involved in the AD pathology. In this study, the putative mediators responsible for QA-induced infiltration of reactive astrocytes in the AD brains have been tried to be identified and the molecular mechanism of the high Aβ production in reactive astrocytes was clarified.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment.2014
Author(s)
Tanizaki Y(1), Kobayashi A, Toujima S, Shiro M, Mizoguchi M, Mabuchi Y, Yagi S, Minami S, Takikawa O, Ino K.
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Journal Title
Cancer Sci.
Volume: 105
Issue: 8
Pages: 966-73
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease.2013
Author(s)
Tajima Y, Ishikawa M, Maekawa K, Murayama M, Senoo Y, Nishimaki-Mogami T, Nakanishi H, Ikeda K, Arita M, Taguchi R, Okuno A, Mikawa R, Niida S, Takikawa O, Saito Y.
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Journal Title
Lipids Health Dis
Volume: 12
Issue: 1
Pages: 68-68
DOI
Related Report
Peer Reviewed
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[Journal Article] Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2, 3- dioxygenase (IDO) inhibitors.2013
Author(s)
Tanaka, Minoru; Li, Xin; Hikawa, Hidemasa; Suzuki, Takafumi; Tsutsumi, Katsuhiko; Sato, Masashi; Takikawa, Osamu; Suzuki, Hideharu; Yokoyama, Yuusaku,
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Journal Title
Bioorganic & Medicinal Chemistry (2013), 21(5), 1159-1165.
Volume: 21(5)
Issue: 5
Pages: 1159-1165
DOI
Related Report
Peer Reviewed
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[Journal Article] NMR-based metabolomics of urine in a mouse model of Alzheimer’s disease: identification of oxidative stress biomarkers2013
Author(s)
Fukuhara, K., Ohno, A., Ota, Y., Senoo, Y., Maekawa, K., Okuda, H., Kurihara, M., Okuno, A., Niida, S., Saito, Y., Takikawa, O
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 52
Issue: 2
Pages: 133-138
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed
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[Journal Article] Association of enhanced activity of indoleamine 2,3-dioxygenase in dendritic cells with the induction of regulatory T cells in chronic hepatitis C infection.2013
Author(s)
Higashitani K, Kanto T, Kuroda S, Yoshio S, Matsubara T, Kakita N, Oze T, Miyazaki M, Sakakibara M, Hiramatsu N, Mita E, Imai Y, Kasahara A, Okuno A, Takikawa O, Hayashi N, Takehara T.
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Journal Title
J Gastroenterol.[Epub ahead of print]
Volume: 未定
NAID
Related Report
Peer Reviewed
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[Presentation] Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease.
Author(s)
Tajima Y, Maekawa Keiko, Ishikawa M, Murayama M, Senoo Y, Nishimaki-Mogami T, Nakanishi H, Kazutaka I, Arita M, Taguchi R, Okuno A, Mikawa R, Niida S, Takikawa O, Saito Y.
Organizer
The 9th Annual Conference of the Metabolomics Society
Place of Presentation
Glasgow, Scotland
Related Report
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[Presentation] Lipidomic analysis of brain and plasma from a mouse model of Alzheimer’s disease.
Author(s)
Tajima Y, Maekawa K, Ishikawa M, Murayama M, Nishimaki-Mogami T, Nakanishi1 H, Ikeda K, Arita M, Taguchi R, Gong J, Okuno A, Niida S, Takikawa O, Saito Y.
Organizer
第53回国際脂質生化学会
Place of Presentation
Banff, Canada
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