Tissue-dependent epigenetic regulation in the establishment of gonadal sex differences and its failure mechanisms

• Project/Area Number: 24590401
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human genetics
• Research Institution: Kobe University
• Principal Investigator: HOSHI NOBUHIKO 神戸大学, (連合)農学研究科(研究院), 教授 (10209223)
• Co-Investigator(Kenkyū-buntansha): YOKOYAMA Toshifumi 神戸大学, 大学院農学研究科, 助教 (10380156)
• Co-Investigator(Renkei-kenkyūsha): TABUCHI Yoshiaki 富山大学, 生命科学先端研究センター (20322109)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 性分化 / 性差 / 性特異的遺伝子発現 / SRY / SOX9 / エピジェネティック制御 / sex reversal / poschiavinus / C57BL/6 / Sox9 / Sry / 性的可塑性 / 性決定 / ニワトリ / 雄化遺伝子 / 性差構築 / 雌化遺伝子 / 分子形態学 / 性的二型性 / Ypos / 性分化関連遺伝子 / 精巣化 / 卵巣化 / 性逆転

Outline of Final Research Achievements

Mammalian sexual fate is determined by the presence or absence of Sry in the bipotential gonads. Breeding the Y chromosome from Mus m. domesticus poschiavinus (pos) strains into C57BL/6J (B6J) mice (B6J-XYpos) has been shown to induce sex reversal. However, our C57BL/6N (B6N)-XYpos mice develop as males as well as females and true hermaphrodites. The onsets of both Sry and Sox9 expressions as determined spatiotemporally by whole-mount immunohistochemistry in the B6N-XYpos gonads occurred 2-3 tail somites later than those in B6N-XYB6 gonads, but earlier than those in B6J-XYpos, respectively. Our study is the first to histologically show the expression and ectopic localization of a female-related gene in the XYpos testes, and a male-related gene in the XYpos ovaries. The results from these and previous experiments indicate that the interplay between genome variants, epigenetics, and developmental gene regulation is crucial for testis development.

Research Products

• [Journal Article] Genes and gene networks involved in sodium fluoride-elicited cell death accompanying endoplasmic reticulum stress in oral epithelial cells (2014)
  • Author(s): Tabuchi Y, Yunoki T, Hoshi N, Suzuki N, Kondo T
  • Journal Title: Int J Mol Sci Volume: 15 Issue: 5 Pages: 8959-8978
  • DOI: 10.3390/ijms15058959
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Peculiar composition of epithelial cells in follicle-associated intestinal cruypts of Peyer’s patches in the rat small intestine. (2014)
  • Author(s): Mantani Y, Yuasa H, Nishida M, Takahara E, Omotehara T, Udayanga KG, Kawano J, Yokoyama T, Hoshi N, Kitagawa H
  • Journal Title: J Vet Med Sci Volume: 76 Pages: 833-838
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Insight into the mechanism of reproductive dysfunction caused by neonicotinoid pesticides. (2014)
  • Author(s): Hoshi N, Hirano T, Omotehara T, Tokumoto J, Umemura Y, Mantani Y, Tanida T, Warita K, Tabuchi Y, Yokoyama T, Kitagawa H.
  • Journal Title: Biol Pharm Bull Volume: 37 Pages: 1439-1443
  • NAID: 130004684796
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ultrastructural and histochemical study on the epithelial differentiation to Paneth cells in the rat ascending colon (2014)
  • Author(s): Mantani, Y., Nishida, M., Yuasa, H., Yamamoto, K., Takahara, E., Omotehara, T., Udayanga, K. G. S., Kawano, J., Yokoyama, T., Hoshi, N. and Kitagawa, H.
  • Journal Title: Anatomical Record Volume: (accepted) Issue: 8 Pages: 1462-1471
  • DOI: 10.1002/ar.22937
  • Peer Reviewed / Open Access
• [Journal Article] Unpredictable chronic stress-induced reproductive suppression associated with the decrease of kisspeptin immunoreactivity in male mice. (2014)
  • Author(s): Hirano T, Kobayashi Y, Omotehara T, Tatsumi A, Hashimoto R, Umemura Y, Nagahara D, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N.
  • Journal Title: J Vet Med Sci Volume: 76 Pages: 1201-1208
  • NAID: 130004432200
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Spatiotemporal expression patterns of doublesex and mab-3 related transcription factor 1 in the chicken developing gonads and Müllerian ducts (2014)
  • Author(s): 1. Omotehara T, Smith CA, Mantani Y, Kobayashi Y, Tatsumi A, Nagahara D, Hashimoto R, Hirano T, Umemura Y, Yokoyama Y, Kitagawa H, Hoshi N
  • Journal Title: Poult. Sci. Volume: 93 Issue: 4 Pages: 953-958
  • DOI: 10.3382/ps.2013-03672
  • Peer Reviewed / Open Access
• [Journal Article] Immunohistochemical and histoplanimetrical study on the endothelial receptor involved in transportation of minute chylomicrons into subepithelial portal blood in intestinal villi of the rat jejunum. (2014)
  • Author(s): Takahara EI, Yuasa H, Nishida M, Mantani Y, Udayanga KG, Qi WM, Takeuchi T, Yokoyama T, Hoshi N, Kitagawa H
  • Journal Title: J Vet Med Sci Volume: 76
  • NAID: 130005067015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A unique pattern of bisphenol a effects on nerve growth factor gene expression in embryonic mouse hypothalamic cell line N-44. (2014)
  • Author(s): Warita K, Mitsuhashi T, Hoshi N, Ohta K, Suzuki S, Takeuchi Y, Miki T
  • Journal Title: Arh Hig Rada Toksikol Volume: 65 Issue: 3 Pages: 293-299
  • DOI: 10.2478/10004-1254-65-2014-2494
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development of oral epithelial cell line ROE2 with differentiation potential from transgenic rats harboring temperature-sensitive simian virus40 large T-antigen gene. (2014)
  • Author(s): Tabuchi Y, Wada S, Ikegame M, Kariya A, Furusawa Y, Hoshi N, Yunoki T, Suzuki N, Takasaki I, Kondo T, Suzuki Y
  • Journal Title: Exp Anim Volume: 63 Pages: 31-44
  • NAID: 130003391601
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Peculiar Composition of Epithelial Cells in Follicle-Associated Intestinal Crypts of Peyer's Patches in the Rat Small Intestine. (2014)
  • Author(s): Mantani Y, Yuasa H, Nishida M, Takahara EI, Omotehara T, Udayanga KG, Kawano J, Yokoyama T, Hoshi N, Kitagawa H.
  • Journal Title: J Vet Med Sci Volume: 76 Pages: 1-10
  • NAID: 130003391293
  • Peer Reviewed
• [Journal Article] Insight into the mechanism of reproductive dysfunction caused by neonicotinoid pesticides (2014)
  • Author(s): Hoshi N, Hirano T, Omotehara T, Tokumoto J, Umemura Y, Mantani Y, Tanida T, Warita K, Yokoyama T, Kitagawa H.
  • Journal Title: Biol Pham Bull Volume: 37 Pages: 1-6
  • NAID: 130004684796
  • Peer Reviewed
• [Journal Article] Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin transactivates aryl hydrocarbon receptor-responsive element III in the tyrosine hydroxylase immunoreactive neurons of the mouse midbrain (2013)
  • Author(s): Tanida T, Tasaka K, Akahoshi E, Ishihara-Sugano M, Saito M, Kawata S, Danjo M, Tokumoto J, Mantani Y, Nagahara D, Tabuchi Y, Yokoyama T, Kitagawa H, Kawata M, Hoshi N
  • Journal Title: Journal of Applied Toxicology Volume: Jan 8 Issue: 2 Pages: 1099-1263
  • DOI: 10.1002/jat.2839
  • Peer Reviewed / Open Access
• [Journal Article] Ferret animal model of corneal endothelial dysfunction for evaluation of drug effect on corneal endothelial wound healing. (2013)
  • Author(s): Sakamoto Y, Okumura N, Koizumi N, Numata R, Kitano J, Yamamoto M, Komada T, Hoshi N.
  • Journal Title: Anim Eye Res Volume: 32 Pages: 15-21
  • NAID: 130005061465
  • Peer Reviewed
• [Journal Article] Ferrets as a new experimental animal model for corneal endothelial research. (2013)
  • Author(s): Sakamoto Y, Okumura N, Koizumi N, Yamasaki K, Kitano J, Numata R, Komada T, Hoshi N.
  • Journal Title: Anim Eye Res Volume: 31 Pages: 3-11
  • NAID: 130003378088
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of steroidogenic acute regulatory protein (StAR) and StAR-binding protein (SBP) expressions in the testes of mice during fetal development. (2013)
  • Author(s): Warita K, Mitsuhashi T, Fukui S, Ohta K, Suzuki S, Miki T, Takeuchi Y, Yokoyama T, Kitagawa H, Sugawara T, Hoshi N.
  • Journal Title: Reprod Biol Volume: 13 Issue: 1 Pages: 92-95
  • DOI: 10.1016/j.repbio.2013.01.172
  • Peer Reviewed
• [Journal Article] Study on the ejaculate characteristics and liquid storage of semen in the common bottlenose dolphin (Tursiops truncatus). (2013)
  • Author(s): Takenaka A, Kashiwagi N, Maezono Y, Nakao T, Uwano Y, Kakizoe Y, Kinoshita K, Kusunoki H, Hoshi N.
  • Journal Title: Jpn J Zoo Wildlife Med Volume: 18 Pages: 107-114
  • NAID: 10031191355
  • Peer Reviewed
• [Journal Article] Histochemical study on the relationship between invasion of indigenous bacteria into intestinal crypts and proliferation of epithelial cells in rat ascending colon. (2013)
  • Author(s): Mantani Y, Takahara E, Takeuchi T, Kawano J, Yokoyama T, Hoshi N, Kitagawa H.
  • Journal Title: J Vet Med Sci Volume: 75 Pages: 939-947
  • Peer Reviewed
• [Journal Article] Effects of exposure to clothianidin on the reproductive system of male quails. (2013)
  • Author(s): Tokumoto J, Danjo M, Kobayashi Y, Kinoshita K, Omotehara T, Tatsumi A, Hashiguchi M, Sekijima T, Kamisoyama H, Yokoyama T, Kitagawa H, Hoshi N.
  • Journal Title: J Vet Med Sci Volume: 75 Pages: 755-760
  • NAID: 130003362133
  • Peer Reviewed
• [Journal Article] Gene expression of epigenetic regulatory factors related to primary silencing mechanism is less susceptible to lower doses of bisphenol A in embryonic hypothalamic cells. (2013)
  • Author(s): Warita K, Mitsuhashi T, Ohta K, Suzuki S, Hoshi N, Miki T, Takeuchi Y
  • Journal Title: J Toxicol Sci Volume: 38 Pages: 285-289
  • NAID: 10031151432
  • Peer Reviewed
• [Journal Article] In vitro evaluation of gene expression changes for gonadotropin-releasing hormone 1, brain-derived neurotrophic factor, and neurotrophic tyrosine kinase, receptor, type 2, in response to bisphenol A treatment. (2013)
  • Author(s): Warita K, Mitsuhashi T, Ohta K, Suzuki S, Hoshi N, Miki T, Takeuchi Y.
  • Journal Title: Congenit Anom Volume: 53 Pages: 42-45
  • NAID: 50008814302
  • Peer Reviewed
• [Journal Article] Downregulation of cytochrome P450scc as an initial adverse effect of adult exposure to diethylstilbestrol on testicular steroidogenesis. (2013)
  • Author(s): Maeda N, Okumura K, Tanaka E, Suzuki T, Miyasho T, Haeno S, Ueda H, Hoshi N, Yokota H.
  • Journal Title: Environ Toxicol Volume: 29 Issue: 12 Pages: 1-8
  • DOI: 10.1002/tox.21875
  • Peer Reviewed
• [Journal Article] Ultrastructural demonstration of the absorption and transportation of minute chylomicrons by subepithelial blood capillaries in rat jejunal villi. (2013)
  • Author(s): Takahara E, Mantani Y, Udayanga KG, Qi WM, Tanida T, Takeuchi T, Yokoyama T, Hoshi N, Kitagawa H.
  • Journal Title: J Vet Med Sci Volume: 75 Pages: 1563-1569
  • NAID: 130003362268
  • Peer Reviewed
• [Journal Article] Study on the ejaculate characteristics and liquid storage of semen in the common bottlenose dolphin (Tursiops truncatus) (2013)
  • Author(s): Takenaka A, Kashiwagi N, Maezono Y, Nakao T, Uwano Y, Kakizoe Y, Kinoshita K, Hoshi N
  • Journal Title: Jpn, J Zoo Wildlife Med Volume: 18
  • NAID: 10031191355
  • Peer Reviewed
• [Journal Article] Effects of Exposure to Clothianidin on the Reproductive System of Male Quails. (2013)
  • Author(s): Tokumoto J, Danjo M, Kobayashi Y, Kinoshita K, Omotehara T, Tatsumi A, Hashiguchi M, Sekijima T, Kamisoyama H, Yokoyama T, Kitagawa H, Hoshi N
  • Journal Title: J Vet Med Sci Volume: 75 Pages: 755-760
  • NAID: 130003362133
  • Peer Reviewed
• [Journal Article] Histoplanimetrical study on the relationship between invasion of indigenous bacteria into intestinal crypts and proliferation of epithelial cells in rat ascending colon. (2013)
  • Author(s): Mantani Y, Takahara EI, Takeuchi T, Kawano J, Yokoyama T, Hoshi N, Kitagawa H
  • Journal Title: J Vet Med Sci Volume: 75
  • NAID: 130003362158
  • Peer Reviewed
• [Journal Article] In vitro evaluation of gene expression changes for gonadotropin-releasing hormone 1, brain-derived neurotrophic factor and neurotrophic tyrosine kinase, receptor, type 2, in response to bisphenol A treatment. (2013)
  • Author(s): Warita K, Mitsuhashi T, Ohta K, Suzuki S, Hoshi N, Miki T, Takeuchi Y
  • Journal Title: Congenit Anom Volume: 51
  • NAID: 50008814302
  • Peer Reviewed
• [Journal Article] Persorption of IgG-Fc-coated particulates from intestinal lumen into portal blood via villous columnar epithelial cells in rat small intestine. (2012)
  • Author(s): Yuji M, Fujimoto M, Qi WM, Takahara EI, Mantani Y, Udayanga KG, Takeuchi T, Warita K, Yokoyama T, Hoshi N, Kitagawa H
  • Journal Title: J Vet Med Sci Volume: 74 Pages: 1447-1452
  • NAID: 130001879738
  • Peer Reviewed
• [Journal Article] Immunohistochemical detection of toll-like receptor-2, -4 and -9 in exocrine glands associated with rat alimentary tract. (2012)
  • Author(s): Mantani Y, Yokoo Y, Kamezaki A, Udayanga KG, Takahara EI, Takeuchi T, Kawano J, Yokoyama T, Hoshi N, Kitagawa H
  • Journal Title: J Vet Med Sci Volume: 74 Pages: 1429-1438
  • NAID: 130001879733
  • Peer Reviewed
• [Journal Article] Microarray and gene ontology analyses reveal downregulation of DNA repair and apoptotic pathways in diethylstilbestrol-exposed testicular Leydig cells. (2012)
  • Author(s): Warita K, Mitsuhashi T, Tabuchi Y, Ohta K, Suzuki S, Hoshi N, Miki T, Takeuchi Y
  • Journal Title: J Toxicol Sci Volume: 37 Pages: 287-295
  • NAID: 10030126622
  • Peer Reviewed
• [Journal Article] Alteration in the apoptosis process of rat esophageal epithelium with hyperproliferation of indigenous bacteria under a physiological condition. (2012)
  • Author(s): Udayanga KGS, Yamamoto K, Miyata H, Yokoo Y, Mantani Y, Takahara EI, Kawano J, Yokoyama T, Hoshi N, Kitagawa H
  • Journal Title: J Vet Med Sci Volume: 74 Pages: 597-605
  • NAID: 130001879887
  • Peer Reviewed
• [Presentation] 生殖腺における性差構築の分子基盤 －その普遍性と多様性 (2015)
  • Author(s): 星 信彦
  • Organizer: 第22回日本行動生殖内分泌研究会［特別講演］
  • Place of Presentation: 神戸大学統合研究拠点コンベンションホール
  • Year and Date: 2015-03-24
  • Invited
• [Presentation] The asymmetric expression of sex-related genes in the early mouse gonads. (2015)
  • Author(s): Umemura, Y., Hashimoto, R., Omotehara, T., Hirano, T., Mantani, Y., Yokoyama, T., Kitagawa, H., Hoshi, N.
  • Organizer: 第120回日本解剖学会
  • Place of Presentation: 神戸国際会議場・展示場（神戸市）
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Selection of stable reference genes for quantitative RT-PCR analyses in developing mouse gonads. (2015)
  • Author(s): Yokoyama, T, Hashimoto, R., Umemura, Y., Omotehara, T., Nagahara, D., Hirano, T., Mantani, Y., Yanai, S., Minami, K., Kubota, N., Mantani, Y., Kitagawa, H., Hoshi, N.
  • Organizer: 第120回日本解剖学会
  • Place of Presentation: 神戸国際会議場・展示場（神戸市）
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Left-right asymmetry of testicular formation in the chicken embryo. (2015)
  • Author(s): Omotehara, T., Hashimoto, R., Umemura, Y., Hirano, T., Mantani, Y., Yokoyama, T., Kitagawa, H. and Hoshi, N.
  • Organizer: 第120回日本解剖学会
  • Place of Presentation: 神戸国際会議場・展示場（神戸市）
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] ニワトリ胚における性腺の形成機構とその左右差 (2014)
  • Author(s): 表原拓也，橋本理恵，梅村ゆりあ，平野哲史，南 貴一，長原大知，湯浅秀人，万谷洋平，横山俊史，北川 浩，星 信彦
  • Organizer: 日本家禽学会2014年度秋季大会
  • Place of Presentation: 鹿児島大学
  • Year and Date: 2014-09-27 – 2014-09-29
• [Presentation] マウス胎子生殖腺における性分化関連遺伝子発現の左右差に関する分子形態学的研究 (2014)
  • Author(s): 橋本理恵，梅村ゆりあ，表原拓也，平野哲史，長原大知，湯浅秀人，久保田直人，南貴一，柳井翔吾，万谷洋平，横山俊史，北川浩，星信彦
  • Organizer: 第157回日本獣医学会
  • Place of Presentation: 北海道大学
  • Year and Date: 2014-09-09 – 2014-09-12
• [Presentation] ニワトリ胚における性腺の形成メカニズムと左右差 (2014)
  • Author(s): 表原拓也，橋本理恵，梅村ゆりあ，平野哲史，南貴一，長原大知，湯浅秀人，久保田直人，柳井翔吾，万谷洋平，横山俊史，北川浩，星信彦
  • Organizer: 第157回日本獣医学会
  • Place of Presentation: 北海道大学
  • Year and Date: 2014-09-09 – 2014-09-12
• [Presentation] 発生中のマウス胎子生殖腺における内部標準遺伝子の検討 (2014)
  • Author(s): 横山俊史，橋本理恵，梅村ゆりあ，表原拓也，長原大知，平野哲史，久保田直人，南貴一，柳井翔吾，万谷洋平，北川浩，星信彦
  • Organizer: 第157回日本獣医学会
  • Place of Presentation: 北海道大学
  • Year and Date: 2014-09-09 – 2014-09-12
• [Presentation] ネオニコチノイド系農薬による生殖機能障害とそのメカニズム (2014)
  • Author(s): 平野哲史，徳本順子，横山俊史，星 信彦
  • Organizer: 第134回日本薬学会
  • Place of Presentation: 熊本大学
  • Invited
• [Presentation] カメ類における「膀胱」の形態機能学的定義 (2013)
  • Author(s): 辰巳敬哉，亀崎直樹，藍原祥子，山下真路，谷口真理，三根佳奈子，坂本未来，表原拓也，小林泰丈，横山俊史，北川 浩，今川智敬，星 信彦
  • Organizer: 第19回日本野生動物医学会
  • Place of Presentation: 京都大学
• [Presentation] 環境ストレス下動物の生殖機能抑制機序に関する形態機能学的研究 (2013)
  • Author(s): 平野哲史，小林泰丈，表原拓也，辰巳敬哉，橋本理恵，梅村ゆりあ，長原大知，横山俊史，北川 浩，星 信彦
  • Organizer: 第19回日本野生動物医学会
  • Place of Presentation: 京都大学
• [Presentation] ウミガメの総排泄腔傍嚢の形態機能学的特徴 (2013)
  • Author(s): 辰巳敬哉，亀崎直樹，藍原祥子，山下真路，谷口真理，三根佳奈子，坂本未来，表原拓也，小林泰丈，横山俊史，北川 浩，今川智敬，星 信彦
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学
• [Presentation] 性腺分化とその破綻メカニズムに関する分子形態学的研究 (2013)
  • Author(s): 表原拓也，木下今日子，長原大知，段上めぐみ，徳本順子，小林泰丈，辰巳敬哉，平野哲史，橋本理恵，梅村ゆりあ，横山俊史，北川 浩，星 信彦
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学
• [Presentation] 環境ストレスが成熟雄マウスの生殖機能に与える影響 (2013)
  • Author(s): 平野哲史，長原大知，表原拓也，小林泰丈，辰巳敬哉，橋本理恵，梅村ゆりあ，横山俊史，北川 浩，星 信彦
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学
• [Presentation] ネオニコチノイド系農薬クロチアニジンが鳥類の繁殖能力に及ぼす影響とその作用機序 (2013)
  • Author(s): 星 信彦，徳本順子，長原大知，表原拓也，小林泰丈，辰巳敬哉，平野哲史，橋本理恵，梅村 ゆりあ，橋口峰雄，関島恒夫，上曽山 博，横山俊史，北川 浩
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学
• [Presentation] ラット空腸腸絨毛における小型乳ビ球門脈血へ移行仕組みに関する免疫組織化学的研究 (2013)
  • Author(s): 高原英一郎，万谷洋平，横山俊史，星 信彦，北川 浩
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学
• [Presentation] ラット上行結腸集合リンパ小節近傍腸陰窩に出現するパネート細胞様外分泌細胞に関する超微形態学的および組織化学的研究 (2013)
  • Author(s): 万谷洋平，高原英一郎，河野潤一，横山俊史，星 信彦，北川 浩
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学
• [Presentation] ラット消化器系における補体成分C3とC4産生部位に関する免疫組織化学的研究 (2013)
  • Author(s): 又吉 緑，万谷洋平，高原英一郎，横山俊史，河野潤一，星 信彦，北川 浩
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学
• [Presentation] マウス海馬の神経新生に及ぼすTCDD毒性の時空間的影響 (2013)
  • Author(s): 小林泰丈，表原拓也，辰巳敬哉，橋本理恵，平野哲史，梅村ゆりあ，長原大知，横山俊史，北川 浩，星 信彦
  • Organizer: 第16回環境ホルモン学会
  • Place of Presentation: 東京大学
• [Presentation] ニワトリ胚における性分化関連遺伝子の時空間的発現に関する分子形態学的研究 (2012)
  • Author(s): 表原拓也，長原大知，木下今日子，段上めぐみ，徳本順子，安田玲子，小林泰丈，辰巳敬哉，横山俊史，北川 浩，星 信彦
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学
• [Presentation] カメ類における「膀胱」の形態機能学的解析 (2012)
  • Author(s): 辰巳 敬哉，亀崎直樹，山下真路，長原大知，木下今日子，段上めぐみ，徳本順子，安田玲子，表原拓也，小林泰丈，横山俊史，北川浩，今川智敬，星信彦
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学
• [Presentation] ターナーモザイク患者の性腺分化とその破綻機構の分子基盤の解明 (2012)
  • Author(s): 長原大知，森實真由美，蛯名康彦，木下今日子，段上めぐみ，徳本順子，安田玲子，表原拓也，小林泰丈，辰巳敬哉，横山俊史，北川 浩，山田秀人，星 信彦
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学
• [Presentation] ネオニコチノイド系農薬が鳥類の繁殖能力に及ぼす影響の分子形態学的研究 (2012)
  • Author(s): 徳本順子，段上めぐみ，小林泰丈，木下今日子，表原拓也，辰巳敬哉，橋口峰雄，関島恒夫，上曽山 博，横山俊史，北川 浩，星 信彦
  • Organizer: 第15回環境ホルモン学会研究発表会
  • Place of Presentation: 東京大学山上会館
• [Presentation] 環境ホルモンと生殖障害機序
  • Author(s): 星 信彦
  • Organizer: 第58回日本生殖医学会
  • Place of Presentation: 神戸国際会議場
  • Invited
• [Presentation] ラット上行結腸における酸好性顆粒を有する腸陰窩上皮細胞に関する形態学的研究
  • Author(s): 万谷洋平, 高原英一郎，河野潤一，横山俊史，星 信彦，北川 浩
  • Organizer: 日本解剖学会第89回近畿支部学術集会
  • Place of Presentation: 奈良先端科学技術大学院大学
• [Presentation] 環境化学物質による生体影響の分子基盤
  • Author(s): 星 信彦
  • Organizer: 第15回日本環境ホルモン学会シンポジウム
  • Place of Presentation: 東京大学山上会館
  • Invited
• [Presentation] Y染色色体腕間逆位を有するXY女性におけるSRY遺伝子子のエピジェネティック異常
  • Author(s): 星 信彦，割田（三觜）友子，割田克彦，田渕圭章，横山俊史，北川 浩，櫻木範明
  • Organizer: 新学術領域研究「性差構築の分子基盤」 若手研究会
  • Place of Presentation: 和歌山マリーナシティロイヤルパインズホテル
• [Presentation] 遺伝子改変性転換マウス（Ypos）の真性半陰陽個体生殖腺における発生形態学的研究
  • Author(s): 橋本理恵，長原大知，木下今日子，段上めぐみ，徳本順子，安田玲子，表原拓也，小林泰丈，辰巳敬哉，横山俊史，北川 浩，星 信彦
  • Organizer: 新学術領域研究「性差構築の分子基盤」 若手研究会
  • Place of Presentation: 和歌山マリーナシティロイヤルパインズホテル
• [Presentation] ネオニコチノイド系農薬が鳥類の繁殖能力に及ぼす影響の基礎的評価
  • Author(s): 徳本順子，長原大知，木下今日子，段上めぐみ，表原拓也，小林泰丈，辰巳敬哉，橋口峰雄，関島恒夫，上曽山 博，横山俊史，北川 浩，星 信彦
  • Organizer: 第88回日本解剖学会近畿支部学術集会
  • Place of Presentation: 神戸大学
• [Presentation] 性腺分化と性分化カスケードに関する分子形態学的研究
  • Author(s): 木下今日子，長原大知，段上めぐみ，徳本順子，表原拓也，小林泰丈，辰巳敬哉，横山俊史，北川浩，星信彦
  • Organizer: 第88回日本解剖学会近畿支部学術集会
  • Place of Presentation: 神戸大学
• [Book] 獣医組織学 改訂第6版 (2013)
  • Author(s): 星 信彦
  • Total Pages: 364
  • Publisher: 学窓社
• [Remarks] 応用動物学 分子形態学・組織生理学（形態機能学教室）
  • URL: http://www.ans.kobe-u.ac.jp/kenkyuuka/sigen/bunsi.html
• [Remarks] 神戸大学大学院農学研究科応用動物学講座分子形態学分野の紹介
  • URL: http://www.ans.kobe-u.ac.jp/kenkyuuka/sigen/bunsi.html
• [Remarks] 神戸大学大学院農学研究科学術報告について
  • URL: http://www.ans.kobe-u.ac.jp/gakujyutu/index.html