Novel approach to primary biliary cirrhosis putting focus on deregulated autophagy
Project/Area Number |
24590409
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Kanazawa University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
SATO Yasunori 金沢大学, 医学系, 講師 (30324073)
NAKANUMA Yasuni 金沢大学, 医学系, 教授 (10115256)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 病理学 / オートファジー / 細胞老化 / 生体分子 |
Outline of Final Research Achievements |
This study revealed that deregulated autophagy followed by cellular senescence in biliary epithelial cells (BECs) may be closely related to the abnormal expression of mitochondrial antigens and following autoimmune pathogenesis in primary biliary cirrhosis (PBC). Cell culture study using mouse biliary epithelial cells supported the immunohistochemical findings in human PBC livers, suggesting autophagy of the mitochondrial proteins. Furthermore, this study disclosed that endoplasmic reticulum stress may play a role in the pathogenesis of deregulated autophagy and cellular senescence in biliary epithelial lesions in PBC.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Evaluation of a new histologic staging and grading system for primary biliary cirrhosis in comparison with classical systems.2013
Author(s)
Kakuda Y, Harada K, Sawada-Kitamura S, Ikeda H, Sato Y, Sasaki M, Okafuji H, Mizukoshi E, Terasaki S, Ohta H, Kasashima S, Kawashima A, Kaizaki Y, Kaneko S, Nakanuma Y.
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Journal Title
Hum Pathol
Volume: -
Issue: 6
Pages: 1107-1117
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] 原発性胆汁性肝硬変(PBC)の病期と肝前駆細胞2014
Author(s)
角田 優子, 原田 憲一, 池田 博子, 岡藤 啓史, 佐藤 保則, 佐々木 素子, 水腰 英四郎, 金子 周一, 中沼 安二
Organizer
第50回日本肝臓学会総会
Place of Presentation
ホテルニューオータニ, 東京
Year and Date
2014-05-29 – 2014-05-30
Related Report
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