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Analysis of A20, modulator of H. pylori associated gastritis.

Research Project

Project/Area Number 24590418
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionOita University

Principal Investigator

UCHIDA Tomohisa  大分大学, 医学部, 助教 (70381035)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsヘリコバクターピロリ / 胃炎 / 消化器病理 / NF-kB / A20
Outline of Final Research Achievements

H. pylori is capable to induce inflammatory responses from host cells through NF-kB. However, little has been known about the process by which gastric epithelial cells counteract H. pylori induced-NF-kB activation to avoid overreactions. A20 is well-known as a NF-kB suppressor and proapoptotic protein. In this study, we investigated the role of A20 in H. pylori-gastric epithelium interaction. We found that upon H. pylori infection, A20 was upregulated in a time- and MOI-dependent manner. A20 mRNA increased sharply within 3 hours and then decreased gradually to the baseline after 36 hours. We transfected cagA vector and H. pylori peptidoglycan into gastric epithelial cells. We found that the transfection of these two agents resulted in a significant increase of A20 expression. These findings indicate that H. pylori induces A20 expression in host cell to restrain H. pylori-activated NF-kB. This negative feed-back loop will establish the balance between host and infectant.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2013 2012

All Presentation (2 results)

  • [Presentation] Low incidence of gastric cancer in thai population is associated with antrum limited H. pylori gastritis2013

    • Author(s)
      Tomohisa Uchida
    • Organizer
      XXVth International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer
    • Place of Presentation
      スペイン マドリッド
    • Related Report
      2013 Research-status Report
  • [Presentation] Helicobacter pylori induces A20 upregulation in gastric epithelial cells2012

    • Author(s)
      Tomohisa Uchida, Lam Tung Nguyen , Toshio Fujioka, Yoshio Yamaoka, Masatsugu Moriyama
    • Organizer
      DDW 2012
    • Place of Presentation
      San Diego
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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