• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of membrane-type serine protease inhibitors in invasion/metastasis of lung cancer

Research Project

Project/Area Number 24590419
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionUniversity of Miyazaki

Principal Investigator

TANAKA Hiroyuki  宮崎大学, 医学部, 助教 (90433060)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords肺癌 / LRP11 / HGF activator inhibitor / serine protease / HGF 肝細胞増殖因子 / LDLR-related protein 11 / 膜蛋白質 / HAI-1 / HGF
Outline of Final Research Achievements

There has been no literature reports about LRP11 in lung cancer. In Northern blot, the brain and prostate tissue and testis in human normal tissue was observed gene expression, mild gene expression was observed in the lung. Gene expression of LRP11 was detected by RT-PCR in lung cancer cell lines. To test anti humna-LRP11 antibodies, we made COS-hLRP11 cells which have expression of human LRP11 protein in COS-7 cells. Immunohistochemically, the cytoplasm and cell membrane of adenocarcinoma, squamous cell carcinoma and small cell carcinoma using surgical material (FFPE tissue) are positive for LRP11 using the anti-human LRP11 antibodies. Currently, we have search role of LRP11, especially relevance of clinocopathological findings and expression of LRP11, in lung cancer, using immunohistochemical study and real-time PCR.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Cutaneous paragonimiasis due to triploid Paragonimus westermani presenting as a non-migratory subcutaneous nodule: a case report.2014

    • Author(s)
      Kodama M, Akaki M, Tanaka H, Maruyama H, Nagayasu E, Yokouchi T, Arimura Y, Kataoka H
    • Journal Title

      J Med Case Rep.

      Volume: 8 Issue: 1 Pages: 1-5

    • DOI

      10.1186/1752-1947-8-346

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hepatocyte growth factor activator inhibitor type 1 is a suppressor of intestinal tumorigenesis.2013

    • Author(s)
      Hoshiko S, Kawaguchi M, Fukushima T, Haruyama Y, Yorita K, Tanaka H, Seiki M, Inatsu H, Kitamura K, Kataoka H.
    • Journal Title

      Cancer Res.

      Volume: 73(8) Issue: 8 Pages: 2659-70

    • DOI

      10.1158/0008-5472.can-12-3337

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Urinary bladder pyogenic granuloma: a case report.2012

    • Author(s)
      Mukai S, Tanaka H, Yamasaki K, Goto T, Onizuka C, Kamoto T, Kataoka H.
    • Journal Title

      J Med Case Rep

      Volume: 6 Issue: 1 Pages: 149-149

    • DOI

      10.1186/1752-1947-6-149

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Loss of membrane-bound serine protease inhibitor HAI-1 inducesoral squamous cell carcinoma cells' invasiveness2012

    • Author(s)
      Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H
    • Journal Title

      J Pathol

      Volume: (Epub ahead of print) Issue: 2 Pages: 181-192

    • DOI

      10.1002/path.3993

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 縦隔内分泌癌を伴ったMEN type 1 の一剖検例2015

    • Author(s)
      田中 弘之
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-04-30 – 2015-05-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肺動脈腫瘍塞栓症を伴った前立腺癌の一剖検例2013

    • Author(s)
      田中弘之、赤木真由美、梅北佳子、賴田顕辞、福島剛、秋山裕、片岡寛章
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      ロイトン札幌、さっぽろ芸文館
    • Related Report
      2013 Research-status Report
  • [Presentation] サイトメガロウイルス性腸炎にクリプトコッカス性心筋炎を合併した一剖検例2012

    • Author(s)
      田中弘之、長安真由美、賴田顕辞、梅北佳子、福島剛、片岡寛章
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京都
    • Related Report
      2012 Research-status Report
  • [Remarks] 宮崎大学医学部病理学講座 腫瘍・再生病態学分野 業績

    • URL

      http://www.med.miyazaki-u.ac.jp/patho2/references.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi