Histological changes of synovium after biologics treatment for RA and disease specific cells
Project/Area Number |
24590423
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Iwate Medical University |
Principal Investigator |
UZUKI Miwa 岩手医科大学, 医学部, 准教授 (50305992)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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Keywords | 関節リウマチ / 生物学的製剤 / 滑膜組織 / サイトカイン / 線維芽細胞様滑膜細胞 / 蛋白分解酵素 / 病理組織 / 治療 |
Outline of Final Research Achievements |
We examined histological and immunohistochemical changes of synovium before and after DMARDs or biologics (Bio) treatment for rheumatoid arthritis (RA). Synovial tissues were obtained from 52 RA patients. Twenty of them took DMARDs before Bio. In responder of Bio, the number of synovial cells, high endothelial venules and inflammatory cells decreased. In addition, the number of positive cells of MMP-3, TNFα, CD68 and CD34 decreased, too. On the other hand, synovial inflammation worsened in non-responder of Bio and immunohistochemical findings showed opposite results to responder. The inflammatory and immunohistochemical scores decreased more massive after treatment by Bio than DMARDs. Especially, the effect of the biologics was massive in non-responder of DMARDs. The results suggest that Bio may stop the vicious circle in responder by decreasing the number of TNFα positive cells and have stronger anti-inflammatory effects especially in non-responder of DMARDs.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Serial block-face scanning electron microscopy combined with double-axis electron beam tomography provides new insight into cellular relationships2013
Author(s)
Sawai T, Kamataki A, Uzuki M, Ishida K, Hanasaka T, Ochi K, Hashimoto T, Kubo T, Morikawa A, Ochi T, Tohyama K
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Journal Title
Microscopy (Oxf)
Volume: 62
Issue: 2
Pages: 317-320
DOI
Related Report
Peer Reviewed
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[Journal Article] World’s first telepathology experiments employing ultra-high-speed internet satellite, nickenemaed “KIZUNA”.2013
Author(s)
Sawai T, Uzuki M, Miura Y, Kamataki A, Matsumura T, Saito K, Kurose A, Osamura YR, Yoshimi N, Kanno H, Moriya T, Ishida Y, Satoh Y, Nakao M, Ogawa E, Matsuo S, Kasai H, Kumagai K, Motoda T, Hopson N
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Journal Title
J Pathol Inform
Volume: 4
Issue: 1
Pages: 24-24
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 生物学的製剤による関節リウマチ滑膜組織の病理学的変化2013
Author(s)
窪田 綾子, 関口 昌之, 宇月 美和, 中村 卓司, 宮崎 芳安, 井形 聡, 塚越 実, 鈴木 大輔, 柘植 新太郎, 高松 諒, 土谷 一晃
Organizer
第41回日本関節病学会
Place of Presentation
名古屋
Related Report
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