Individualization of ovarian tumors for approaching new strategy associated with hypoxia-associated factors
| Project/Area Number |
24590424
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 卵巣明細胞癌 / 治療の個別化 / 低酸素関連因子 / 卵巣腫瘍 / 低酸素環境 / HIF-1α / mTOR |
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| Outline of Final Research Achievements |
1) The aim of this study was to clarify the expression profile of HDAC7 in CCC. As a result, we concluded that HDAC7 may fail to become an indicator of the clinical outcome. 2) Lately, HDAC attracts the attention as target molecule of the cancer therapy. In this theme, we assessed mRNAs expression of HDAC in variable cultured ovarian cancer cell lines. HDAC inhibitor (HDI)-induced changes in the expression of mRNAs for HDAC7, HIF-1α and VEGF were also attempted to assess the potential of HDI as anti-cancer drug. As a result, it was supposed that the response to HDI may vary greatly among the ovarian carcinomas but may be a suitable candidate for HDI treatment. 3) High frequency of polymorphic variants of HIF-1α gene (C1772T) has been reported in variable malignancies. It was carried out to demonstrate HIF-1α gene polymorphic variation in CCC, by HIF-1α sequence analysis. HIF-1α gene variation was detected in 23.6%.
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Report
(5 results)
Research Products
(19 results)
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[Journal Article] Serum folate receptor alpha as a biomarker for ovarian cancer: Implications for diagnosis, prognosis and predicting its local tumor expression.2016
Author(s)
Kurosaki A, Hasegawa K, Kato T, Abe K, Hanaoka T, Miyara A, O'Shannessy DJ, Somers EB, Yasuda M, Sekino T, Fujiwara K.
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Journal Title
Int J Cancer.
Volume: 138
Issue: 8
Pages: 1994-2002
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effect of lymphovascular space invasion on survival of stage I epithelial ovarian cancer.2014
Author(s)
Matsuo K, Yoshino K, Hiramatsu K, Banzai C, Hasegawa K, Yasuda M, Nishimura M, Sheridan TB, Ikeda Y, Shiki Y, Mabuchi S, Enomoto T, Kimura T, Fujiwara K, Roman LD, Sood AK.
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Journal Title
Obstet Gynecol.
Volume: 123
Pages: 957-965
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effect of Lymphovascular Space Invasion on2014
Author(s)
Koji Matsuo, Kiyoshi Yoshino, Kosuke Hiramatsu, Chiaki Banzai, Kosei Hasegawa, Masanori Yasuda, Masato Nishimura, Todd B. Sheridan, Yuji Ikeda, Yasuhiko Shiki, Seiji Mabuchi, Takayuki Enomoto, Tadashi Kimura, Keiichi Fujiwara, Lynda D. Roman, and Anil K. Sood
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Journal Title
Obstet Gynecol
Volume: 123
Issue: 5
Pages: 957-65
DOI
Related Report
Peer Reviewed
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