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Individualization of ovarian tumors for approaching new strategy associated with hypoxia-associated factors

Research Project

Project/Area Number 24590424
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionSaitama Medical University

Principal Investigator

Yasuda Masanori  埼玉医科大学, 医学部, 教授 (50242508)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords卵巣明細胞癌 / 治療の個別化 / 低酸素関連因子 / 卵巣腫瘍 / 低酸素環境 / HIF-1α / mTOR
Outline of Final Research Achievements

1) The aim of this study was to clarify the expression profile of HDAC7 in CCC. As a result, we concluded that HDAC7 may fail to become an indicator of the clinical outcome. 2) Lately, HDAC attracts the attention as target molecule of the cancer therapy. In this theme, we assessed mRNAs expression of HDAC in variable cultured ovarian cancer cell lines. HDAC inhibitor (HDI)-induced changes in the expression of mRNAs for HDAC7, HIF-1α and VEGF were also attempted to assess the potential of HDI as anti-cancer drug. As a result, it was supposed that the response to HDI may vary greatly among the ovarian carcinomas but may be a suitable candidate for HDI treatment. 3) High frequency of polymorphic variants of HIF-1α gene (C1772T) has been reported in variable malignancies. It was carried out to demonstrate HIF-1α gene polymorphic variation in CCC, by HIF-1α sequence analysis. HIF-1α gene variation was detected in 23.6%.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014 2013 2012

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 7 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 6 results)

  • [Journal Article] Utility of histogram analysis of apparent diffusion coefficient maps obtained using 3.0T MRI for distinguishing uterine carcinosarcoma from endometrial carcinoma.2016

    • Author(s)
      Takahashi M, Kozawa E, Tanisaka M, Hasegawa K, Yasuda M, Sakai F.
    • Journal Title

      J Magn Reson Imaging.

      Volume: 43 Issue: 6 Pages: 1301-7

    • DOI

      10.1002/jmri.25103

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum folate receptor alpha as a biomarker for ovarian cancer: Implications for diagnosis, prognosis and predicting its local tumor expression.2016

    • Author(s)
      Kurosaki A, Hasegawa K, Kato T, Abe K, Hanaoka T, Miyara A, O'Shannessy DJ, Somers EB, Yasuda M, Sekino T, Fujiwara K.
    • Journal Title

      Int J Cancer.

      Volume: 138 Issue: 8 Pages: 1994-2002

    • DOI

      10.1002/ijc.29937

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synchronous mucinous metaplasia and neoplasia of the female genital tract with external urethral meatus neoplasm: A case report.2015

    • Author(s)
      Ikeda Y, Yasuda M, Kato T, Yano Y, Kurosaki A, Hasegawa K
    • Journal Title

      Gynecol Oncol Rep.

      Volume: 12 Pages: 27-30

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunohistochemical characterization of endometrial carcinomas: endometrioid, serous and clear cell adenocarcinomas in association with genetic analysis.2014

    • Author(s)
      Yasuda Masanori
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 40 Pages: 2167-2176

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma simulating fetal gut in a postmenopausal woman.2014

    • Author(s)
      Morimoto A, Sudo T, Sakuma T, Yasuda M, Fujiwara K
    • Journal Title

      Gynecol Oncol Case Rep.

      Volume: 12 Pages: 24-26

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diffusion-weighted MR imaging findings of ovarian adenocarcinofibromas and adenofibromas.2014

    • Author(s)
      Kozawa E, Inoue K, Takahashi M, Kato T, Yasuda M, Kimura F
    • Journal Title

      Clin Imaging.

      Volume: 38 Pages: 483-489

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of lymphovascular space invasion on survival of stage I epithelial ovarian cancer.2014

    • Author(s)
      Matsuo K, Yoshino K, Hiramatsu K, Banzai C, Hasegawa K, Yasuda M, Nishimura M, Sheridan TB, Ikeda Y, Shiki Y, Mabuchi S, Enomoto T, Kimura T, Fujiwara K, Roman LD, Sood AK.
    • Journal Title

      Obstet Gynecol.

      Volume: 123 Pages: 957-965

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Lymphovascular Space Invasion on2014

    • Author(s)
      Koji Matsuo, Kiyoshi Yoshino, Kosuke Hiramatsu, Chiaki Banzai, Kosei Hasegawa, Masanori Yasuda, Masato Nishimura, Todd B. Sheridan, Yuji Ikeda, Yasuhiko Shiki, Seiji Mabuchi, Takayuki Enomoto, Tadashi Kimura, Keiichi Fujiwara, Lynda D. Roman, and Anil K. Sood
    • Journal Title

      Obstet Gynecol

      Volume: 123 Issue: 5 Pages: 957-65

    • DOI

      10.1097/aog.0000000000000240

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alterations of hypoxia-induced factor signaling pathway due to mammalian target of rapamycin (mTOR) suppression in ovarian clear cell adenocarcinoma: in vivo and in vitro explorations for clinical trial2013

    • Author(s)
      Hirasawa T, Miyazawa M, Yasuda M, Shida M, Ikeda M, Kajiwara H, Matsui N, Fujita M, Muramatsu T, Mikami M
    • Journal Title

      Int J Gynecol Cancer

      Volume: 23 Issue: 7 Pages: 1210-1218

    • DOI

      10.1097/igc.0b013e31829d2d51

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endometrial intraepithelial carcinoma in association with polyp: review of eight cases.2013

    • Author(s)
      Yasuda M, Katoh T, Hori S, Suzuki K, Ohno K, Maruyama M, Matsui N, Miyazaki S, Ogane N, Kameda Y.
    • Journal Title

      Diagn Pathol.

      Volume: 15 Issue: 1 Pages: 25-25

    • DOI

      10.1186/1746-1596-8-25

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estrogen-producing endometrioid adenocarcinoma resembling sex cord-stromal tumor of the ovary: a review of four postmenopausal cases.2012

    • Author(s)
      Katoh T, Yasuda M, Hasegawa K, Kozawa E, Maniwa J, Sasano H.
    • Journal Title

      Diagn Pathol.

      Volume: 28 Issue: 1 Pages: 164-164

    • DOI

      10.1186/1746-1596-7-164

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 子宮体癌の初期病変・前駆病変の実際―WHO分類の考え方―2015

    • Author(s)
      安田政実
    • Organizer
      第43回日本婦人科病理学会学術集会
    • Place of Presentation
      東京女子医科大学(東京都、新宿区)
    • Year and Date
      2015-12-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 卵巣癌における病理組織の最新の話題2015

    • Author(s)
      安田政実
    • Organizer
      第1回甲信病理フォーラム
    • Place of Presentation
      山梨大学医学部(中央市、山梨県)
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 女性生殖器と外尿道口に同時に発生した粘液性腫瘍の一例2015

    • Author(s)
      成清羊佳,加藤智美,細沼沙紀,鎌倉靖夫,周東真代,渡辺宏志,矢野友梨,小澤栄人,永田耕治,安田政実
    • Organizer
      第54回日本臨床細胞学会秋期大会
    • Place of Presentation
      名古屋国際会議場(名古屋市、愛知県)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 卵巣腫瘍 “理論と現実の狭間で”2015

    • Author(s)
      安田政実
    • Organizer
      第7回関西婦人科腫瘍・病理懇話会
    • Place of Presentation
      京都大学(京都府、京都市)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 婦人科領域の病理・細胞診. 卵巣腫瘍の原点:組織発生と分類2015

    • Author(s)
      安田政実
    • Organizer
      細胞検査研究班研修会
    • Place of Presentation
      サーモフィッシャーサイエンティフィック株式会社(神奈川県、横浜市)
    • Year and Date
      2015-07-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 子宮内膜ポリープ由来癌の細胞像および臨床病理学的背景2015

    • Author(s)
      加藤智美,佐瀬智子,鎌倉靖夫,菊地淳,大金直樹,小澤栄人,今井雄一,長谷川幸清,梶原博,安田政実
    • Organizer
      第56回日本臨床細胞学会総会(春期大会)
    • Place of Presentation
      くにびきメッセ・松江テルサ(松江市、島根県)
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Germ cell tumour of the ovary2015

    • Author(s)
      Yasuda M.
    • Organizer
      The 19th Korea Taiwan Japan Joint Meeting for Gynecological Pathology
    • Place of Presentation
      名古屋市立大学(名古屋市、愛知県)
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 卵巣細胞診の読み方,ピットホール2014

    • Author(s)
      安田政実
    • Organizer
      長崎県臨床細胞学会・学術集会
    • Place of Presentation
      長崎大学医学部(長崎県長崎市)
    • Year and Date
      2014-06-21 – 2014-06-22
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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