Invasive pattern of pancreatic carcinoma: special reference to PanIN and IPMN

• Project/Area Number: 24590425
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Saitama Medical University
• Principal Investigator: SHIMIZU Michio 埼玉医科大学, 医学部, 教授 (60226256)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: PanIN / IPMN / pancreatic cancer / gastric type / intestinal type / tissue microarray / Tissue Microarray

Outline of Final Research Achievements

Pancreatic carcinomas is considered to be derived from either PanIN or IPMN. Especially, PanIN-3 is an important lesion, however; there may be de novo cancer present. Regarding the histologic type of pancreatic carcinoma, gastric type IPMN usually progressed to ordinary adenocarcinoma, whereas intestinal type IPMN mainly showed mucinous (colloid) carcinoma. When pancreatic cancer cells invaded into normal pancreas, pancreatic islets tended to be preserved to the end. Using Tissue Microarray method, pancreatic cancer cells could reveal focal positivity for HNF-1 beta, chromogranin A, p63 or BCL-10. These immunohistochemical results may have influence with histological variation of pancreatic cancer.

Research Products

• [Journal Article] 腹水中に腺癌細胞と扁平上皮癌細胞の両者を認めた膵腺扁平上皮癌の1例 (2013)
  • Author(s): 金野美年子，土居美枝子，佐々木惇，安田政実，清水道生
  • Journal Title: J Jpn Soc Clin Cytol Volume: 52 Pages: 169-170
  • NAID: 10031138853
  • Peer Reviewed
• [Journal Article] Imaging Studies of Intraductal Tubulopapillary Neoplasms of the Pancreas: 2-Tone Duct Sign and Cork-of-Wine-Bottle Sign as Indicators of Intraductal Tumor Growth (2012)
  • Author(s): Motosugi U, Yamaguchi H, Furukawa T, Ichikawa T, Hatori T, Fujita I, Yamamoto M, Motoi F, Kanno A, Watanabe T, Koike N, Koyama I, Kobayashi J, Shimizu M
  • Journal Title: J Comput Assist Tomogr Volume: 36 Issue: 6 Pages: 710-717
  • DOI: 10.1097/rct.0b013e31826d1fc8
  • Peer Reviewed
• [Presentation] Revised recommendation for assessing precursor lesions in the pancreas (2015)
  • Author(s): Basturk O, Shimizu M, et al.
  • Organizer: 2015 United States & Canadian Academy of Pathology Annual Meeting
  • Place of Presentation: Boston, MA, USA
  • Year and Date: 2015-03-21 – 2015-03-27
• [Presentation] Invasive patterns of islets of Langerhans by pancreatic carcinoma cells (2013)
  • Author(s): Shimizu M, Jin L, Yamaguchi H, Nagata K, Sasaki A, Yasuda M
  • Organizer: cap'13
  • Place of Presentation: Orlando, USA
• [Presentation] Adenosquamous carcinoma of the pancreas: its clinicopathological and immuhohistochemical findings (2012)
  • Author(s): Shimizu M, Jin L, Yamaguchi H, Nagata K, Sasaki A, Yasuda M
  • Organizer: cap'12
  • Place of Presentation: San Diego, USA