Factors related with carcinogenesis and invasion of ulcerative colitis-associated cancer
| Project/Area Number |
24590426
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Toho University (2013-2014)
Kitasato University (2012) |
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Principal Investigator |
MIKAMI Tetuo 東邦大学, 医学部, 教授 (90286352)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Yuichi 北里大学, 医療衛生学部, 教授 (30178793)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 潰瘍性大腸炎 / 癌 / 大腸癌 / 大腸がん |
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| Outline of Final Research Achievements |
Carcinogenic pathway from chronic inflammation is considered as an important pathway. Carcinogenesis in ulcerative colitis is one of the important diseases. We analyzed a cell adhesion molecule, CD44, in ulcerative colitis-associated neoplastic lesions, dysplasia and cancer. In addition, we searched for proteins which are specifically up- or down-regulated in ulcerative colitis mucosa. As a result, CD44 was down regulated in ulcerative colitis-associated lesions, and its expression was considered to be associated with Adam17 expression. Carbonic anhydrase 2 was identified as one of the proteins down-regulated in ulcerative colitis mucosa.
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Report
(4 results)
Research Products
(5 results)
