| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Carcinogenic pathway from chronic inflammation is considered as an important pathway. Carcinogenesis in ulcerative colitis is one of the important diseases. We analyzed a cell adhesion molecule, CD44, in ulcerative colitis-associated neoplastic lesions, dysplasia and cancer. In addition, we searched for proteins which are specifically up- or down-regulated in ulcerative colitis mucosa. As a result, CD44 was down regulated in ulcerative colitis-associated lesions, and its expression was considered to be associated with Adam17 expression. Carbonic anhydrase 2 was identified as one of the proteins down-regulated in ulcerative colitis mucosa.
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