• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Factors related with carcinogenesis and invasion of ulcerative colitis-associated cancer

Research Project

Project/Area Number 24590426
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionToho University (2013-2014)
Kitasato University (2012)

Principal Investigator

MIKAMI Tetuo  東邦大学, 医学部, 教授 (90286352)

Co-Investigator(Renkei-kenkyūsha) SATO Yuichi  北里大学, 医療衛生学部, 教授 (30178793)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords潰瘍性大腸炎 / 癌 / 大腸癌 / 大腸がん
Outline of Final Research Achievements

Carcinogenic pathway from chronic inflammation is considered as an important pathway. Carcinogenesis in ulcerative colitis is one of the important diseases. We analyzed a cell adhesion molecule, CD44, in ulcerative colitis-associated neoplastic lesions, dysplasia and cancer. In addition, we searched for proteins which are specifically up- or down-regulated in ulcerative colitis mucosa. As a result, CD44 was down regulated in ulcerative colitis-associated lesions, and its expression was considered to be associated with Adam17 expression. Carbonic anhydrase 2 was identified as one of the proteins down-regulated in ulcerative colitis mucosa.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Tumor budding, myofibroblast proliferation, and fibrosis in obstructing colon carcinoma: the roles of Hsp47 and basic fibroblast growth factor2013

    • Author(s)
      Xu CJ, Mikami T, Nakamura T, Tsuruta T, Nakada N, Yanagisawa N, Jiang SX, Okayasu I
    • Journal Title

      Pathology Research and Practice

      Volume: 209 Issue: 2 Pages: 69-74

    • DOI

      10.1016/j.prp.2012.10.008

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 潰瘍性大腸炎粘膜および潰瘍性大腸炎関連癌におけるcarbonic anhydrase 2の発現の検討2014

    • Author(s)
      仲田典広、三上哲夫、一戸昌明、柳澤信之、岡安勲、村雲芳樹
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県 横浜市)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 潰瘍性大腸炎粘膜および潰瘍性大腸炎関連癌におけるCarbonic anhydrase 2発現の検討

    • Author(s)
      仲田典広、三上哲夫、一戸昌明、柳澤信之、岡安勲、村雲芳樹
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場(広島県広島市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 潰瘍性大腸炎関連腫瘍では早期からCD44の発現が低下している

    • Author(s)
      三上哲夫、林宏行、沼田賀子、蒋世旭、仲田典広、一戸昌明、岡安勲、村雲芳樹
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 潰瘍性大腸炎関連腫瘍では早期からCD44の発現が低下している

    • Author(s)
      三上哲夫、林宏行、沼田賀子、仲田典広、一戸昌明、岡安勲、村雲芳樹
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi