| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Lung adenocarcinoma with micropapillary component (AC-MPC) is more malignant than conventional adenocarcinoma (CAC). On proteomics based on 2-DE, vimentin was 3.5-fold up-regulated in AC-MPC. Immunostaining in 101 AC-MPC and 119 CAC revealed that vimentin was expressed in 95 MPC and the expression scores were higher than those of well- and moderately differentiated CAC (P<0.0001), but not different from those of poorly differentiated CAC (P=0.561). Even within the AC-MPC entity, higher vimentin expression was correlated with more frequent vascular invasion and node metastasis (P<0.02), and multivariate analysis showed that high vimentin expression was an independent indicator of adverse prognosis (P<0.0053). In conclusion, vimentin expression is prevalent and up-regulated in MPC, which might reflect the biological essence of poorer differentiation or dedifferentiation, and have a role in the acquisition and increase of invasiveness and consequent more malignant nature of MPC.
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