| Project/Area Number |
24590434
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | The Japanese Red Cross Toyota College of Nursing |
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Principal Investigator |
KUROKAWA Kei 日本赤十字豊田看護大学, 看護学部, 教授 (90399030)
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| Co-Investigator(Kenkyū-buntansha) |
IWASHITA Toshihide 浜松医科大学, 医学部, 教授 (00283432)
MURAKAMI Hideki 愛知医科大学, 医学部, 准教授 (90303619)
SAGA Shinsuke 愛知医科大学, 医学部, 教授 (40144141)
川井 久美 名古屋大学, 医学(系)研究科(研究院), 准教授 (50362231)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Yoshiyuki 名古屋大学, 医学部, 准教授 (40432273)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経芽細胞腫 / 表面マーカー / 幹細胞 / 神経芽細胞種 / 分化階層 / 細胞表面マーカー / 副腎髄質 / 神経芽腫 / 交感神経神経堤幹細胞 / 神経芽腫幹細胞 / 腫瘍幹細胞 |
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| Outline of Final Research Achievements |
In neuroblastoma cell lines, morphological transconversion between cells with neuronal process (N-type) and flat cells (S-type) are observed. Transconversion of cell surface markers correlating with morphological changes and differentiation of neuroblastoma cells were found. From several transconverting cell fractions, a cell population with a fixed combination of cell surface markers was derived. This population was morphologically N-type with rapid proliferation. It was suggested that this population forms a lower rank of differention than transconverting cell populations from the view point of cell surface markers. A definite hierarchy like developmental process of neural crest cell differentiation was not observed in neuroblastoma.
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