Histopathological evaluation for pathogenesis of aortic aneurysm formation

• Project/Area Number: 24590435
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Hyogo Medical University
• Principal Investigator: Hao Hiroyuki 兵庫医科大学, 医学部, 准教授 (40393243)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 大動脈瘤 / 鉄代謝 / 動脈硬化 / 炎症 / 小胞体ストレス / 血管平滑筋細胞 / 腹部大動脈瘤 / 鉄 / 酸化ストレス / アンギオテンシン / マクロファージ / 平滑筋細胞の分化 / オランダ / スイス

Outline of Final Research Achievements

It has not been investigated whether iron plays a role in abdominal aortic aneurysm (AAA) formation　through oxidative stress and inflammation. We examined whether iron is involved in the pathophysiology of AAA formation using human AAA walls and murine AAA models.Iron was accumulated in human and murine AAA walls compared with non-AAA walls. We next investigated the effects of dietary iron restriction on AAA formation in mice. Iron restriction reduced the incidence of AAA formation with attenuation of oxidative stress and inflammation.
Iron is involved in the pathophysiology of AAA formation with oxidative stress and inflammation. Dietary iron restriction could be a new therapeutic strategy for AAA progression.

Research Products

• [Journal Article] Aortic iron overload with oxidative stress and inflammation in human and murine abdominal aortic aneurysm. (2015)
  • Author(s): Hao H, Sawada T, Naito Y, Oboshi M, Hirotani S, Mitsuno M, Miyamoto Y, Hirota S, Masuyama T
  • Journal Title: Arteriosclerosis Thrombosis and Vascular Biology Volume: 35 Issue: 6 Pages: 1507-1514
  • DOI: 10.1161/atvbaha.115.305586
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Distribution of myofibroblast and tenascin-C in cystic adventitial disease: comparison with ganglion (2013)
  • Author(s): Hao H, Ishibashi-Ueda H, Nishida N, Kawakami R, Tsukamoto Y, Tsujimoto M, Hirota S.
  • Journal Title: Pathology International Volume: 63 Issue: 12 Pages: 591-8
  • DOI: 10.1111/pin.12119
  • Peer Reviewed
• [Presentation] Involvement of iron metabolism in pathogenesis of abdominal aortic aneurysm (2015)
  • Author(s): Hao H
  • Organizer: The 9th Aso International Meeting
  • Place of Presentation: 熊本
  • Year and Date: 2015-05-15
• [Presentation] Iron involvement in human abdominal aortic aneurysm. (2014)
  • Author(s): Sawada H, Naito Y, Hao H, Oboshi M, Iwasaku T, Okuhara Y, Morisawa D, Eguchi A, Hirotani S, Hirota S, Miyamoto Y, Ohyanagi M, Masuyama T
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: 京都
  • Year and Date: 2014-04-15
• [Presentation] The true character of lipid rich plaque by intravascular imaging: Message from pathologist to cardiologist
  • Author(s): Hao H, Fujii K, Shibuya M, Imanaka T, Takagi Y, Kawakami R, Hirota S
  • Organizer: European Society of Cardiology Congress 2013
  • Place of Presentation: Amsterdam, Holland
• [Presentation] Involvement of iron accumulation in human abdominal aortic aneurysm
  • Author(s): Sawada H, Naito Y, Hao H, Oboshi M, Iwasaku T, Okuhara Y, Morisawa D, Eguchi A, Hirotani S, Miyamoto Y, Hirota S, Masuyama T
  • Organizer: American College of Cardiology Scientific session 2014
  • Place of Presentation: Washington DC, USA
• [Presentation] Coronary artery plaques in maintenace dialysis patients: Histological features and ex vivo optical coherence tomography imaging
  • Author(s): Hao H, Kawakami R, Imanaka T, Fujii K, Masuyama T, Ishibashi-Ueda T, Hirota S
  • Organizer: American College of Cardiology Scientific session 2014
  • Place of Presentation: Washington DC, USA
• [Presentation] Iron involvement in human abdominal aortic aneurysm
  • Author(s): Sawada H, Naito Y, Hao H, Oboshi M, Iwasaku T, Okuhara Y, Morisawa D, Eguchi A, Hirotani S, Hirota S, Miyamoto Y, Ohyanagi M, Masuyama T
  • Organizer: International Vascular Biology Meeting 2014
  • Place of Presentation: 京都