The assessment of malignant degree of carcinoma based on histological and biological factors of carcinoma.
Project/Area Number |
24590439
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Saitama Medical University (2013-2014) National Center of Neurology and Psychiatry (2012) |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 乳癌 / 癌間質 / 癌悪性度 / 異型腫瘍間質線維芽細胞 / リンパ管腫瘍塞栓 / 静脈腫瘍塞栓 / 線維芽細胞 / リンパ管 / 静脈 / リンパ節 / 癌 / 癌細胞癌間質細胞相互作用 / 脈管内癌組織 / 上皮間葉移行 / 転移 |
Outline of Final Research Achievements |
The present study clearly demonstrated that the best factor for accurately predicting locoregional recurrence was grade 3 lymph vessel tumor embolus, followed by type 2 invasive ductal carcinoma, grade 2 lymph vessel tumor embolus, primary invasive tumor cell-related factors and >5 mitotic figures in metastatic carcinomas to the lymph node. We classified 263 invasive ductal carcinomas into the following three grades according to the numbers of mitotic and apoptotic figures in tumor cells located in blood vessels within 1 high-power field: grade 0, grade 1, and grade 2. Multivariate analyses with well-known prognostic factors demonstrated that grade 2 blood vessel tumor emboli significantly increased the hazard ratios for tumor recurrence independent of the nodal status, pathological TNM stage, hormone receptor status or HER2 status.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Grading system for blood vessel tumor emboli of invasive ductal carcinoma of the breast.2015
Author(s)
Sugiyama M, Hasebe T, Shimada H, Takeuchi H, Shimizu K, Shimizu M, Yasuda M, Ueda S, Shigekawa T, Osaki A, Saeki T.
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Journal Title
Hum Pathol
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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