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Role of NKG2D ligands in prediction of response to cancer antibody therapy

Research Project

Project/Area Number 24590441
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionHokkaido University

Principal Investigator

Matsuno Yoshihiro  北海道大学, 大学病院, 教授 (00199829)

Co-Investigator(Kenkyū-buntansha) HATANAKA Yutaka  北海道大学, 北海道大学病院, 特任講師 (30589924)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsNKG2Dリガンド / 分子標的治療 / ADCC活性 / 治療効果予測
Outline of Final Research Achievements

In this study, we analyzed the protein expression profile of NKG2DL in breast cancer and malignant lymphoma, and examined the relationship with clinicopathological factors and patient survival to estimate an impact of NKG2DL modulation in antibody therapies. We showed that the clinicopathological significance of NKG2DL was different depending on molecular subtypes in breast cancer. Moreover, it was suggested that the significance of NKG2DL in rituximab-treated DLBCL might depend on cancer immunoresponse or cellular stress.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (36 results)

All 2016 2015 2014 2013 2012

All Journal Article (18 results) (of which Peer Reviewed: 17 results,  Acknowledgement Compliant: 1 results,  Open Access: 3 results) Presentation (15 results) (of which Invited: 4 results) Book (3 results)

  • [Journal Article] Comparative genetic analysis of a rare synchronous collision tumor composed of malignant pleural mesothelioma and primary pulmonary adenocarcinoma.2016

    • Author(s)
      Naka T, Hatanaka Y, Marukawa K, Okada H, Hatanaka KC, Sakakibara-Konishi J, Oizumi S, Hida Y, Kaga K, Mitsuhashi T, Matsuno Y
    • Journal Title

      Diagn Pathol

      Volume: 11 Issue: 1 Pages: 1-6

    • DOI

      10.1186/s13000-016-0488-0

    • NAID

      120005766752

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Natural History of Pulmonary Subsolid Nodules: A Prospective Multicenter Study.2016

    • Author(s)
      Kakinuma R, Noguchi M, Ashizawa K, Kuriyama K, Maeshima AM, Koizumi N, Kondo T, Matsuguma H, Nitta N, Ohmatsu H, Okami J, Suehisa H, Yamaji T, Kodama K, Mori K, Yamada K, Matsuno Y, Murayama S, Murata K.
    • Journal Title

      J Thorac Oncol.

      Volume: Epub ahead of print Issue: 7 Pages: 1012-1028

    • DOI

      10.1016/j.jtho.2016.04.006

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers2015

    • Author(s)
      Honma R, Kinoshita I, Miyoshi E, Tomaru U, Matsuno Y, Shimizu Y, Takeuchi S, Kobayashi Y, Kaga K, Taniguchi N, Dosaka-Akita H
    • Journal Title

      Oncology

      Volume: 88 Issue: 5 Pages: 298-305

    • DOI

      10.1159/000369495

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Importance of luminal membrane mesothelin expression in intraductal papillary mucinous neoplasms.2015

    • Author(s)
      Einama T, Kamachi H, Nishihara H, Homma S, Kanno H, Ishikawa M, Kawamata F, Konishi Y, Sato M, Tahara M, Okada K, Muraoka S, Kamiyama T, Taketomi A, Matsuno Y, Furukawa H, Todo S
    • Journal Title

      Oncol Lett

      Volume: 9 Pages: 1583-1589

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Decreased proteosomal function accelerates cigarette smoke-induced pulmonary emphysema in mice.2015

    • Author(s)
      Yamada Y, Tomaru U, Ishizu A, Ito T, Kiuchi T, Ono A, Miyajima S, Nagai K, Higashi T, Matsuno Y, Dosaka-Akita H, Nishimura M, Miwa S, Kasahara M
    • Journal Title

      Lab Invest

      Volume: 95 Issue: 6 Pages: 625-634

    • DOI

      10.1038/labinvest.2015.43

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical Validation and Expression Profiling of NKG2D Ligands in a Wide Spectrum of Human Epithelial Neoplasms.2015

    • Author(s)
      Fujita H, Hatanaka Y, Sutoh Y, Suzuki Y, Oba K, Hatanaka KC, Mitsuhashi T, Otsuka N, Fugo K, Kasahara M, Matsuno Y.
    • Journal Title

      J Histochem Cytochem.

      Volume: 63 Issue: 3 Pages: 217-227

    • DOI

      10.1369/0022155414563800

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome.2014

    • Author(s)
      Shiratori S, Fujimoto K, Nishimura M, Hatanaka KC, Kosugi-Kanaya M, Okada K, Sugita J, Shigematsu A, Hashimoto D, Endo T, Kondo T, Abe R, Hashino S, Matsuno Y, Shimizu H, Teshima T.
    • Journal Title

      Hematol Oncol

      Volume: Epub Ahead of Print Issue: 1 Pages: 9-16

    • DOI

      10.1002/hon.2162

    • NAID

      120005981361

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic biomarkers in patients with localized natural killer/T-cell lymphoma treated with concurrent chemoradiotherapy.2014

    • Author(s)
      Yamaguchi M, Takata K, Yoshino T, Ishizuka N, Oguchi M, Kobayashi Y, Isobe Y, Ishizawa K, Kubota N, Itoh K, Usui N, Miyazaki K, Wasada I, Nakamura S, Matsuno Y, Oshimi K, Kinoshita T, Tsukasaki K, Tobinai K.
    • Journal Title

      Cancer Sci

      Volume: 105 Issue: 11 Pages: 1435-1441

    • DOI

      10.1111/cas.12526

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reproducibility of histopathological diagnosis in poorly differentiated NSCLC: an international multiobserver study.2014

    • Author(s)
      Thunnissen E, Noguchi M, Aisner S, Beasley MB, Brambilla E, Chirieac LR, Chung JH, Dacic S, Geisinger KR, Hirsch FR, Ishikawa Y, Kerr KM, Lantejoul S, Matsuno Y, Minami Y, Moreira AL, Pelosi G, Petersen I, Roggli V, Travis WD, Wistuba I, Yatabe Y, Dziadziuszko R, Witte B, Tsao MS, Nicholson AG.
    • Journal Title

      J Thorac Oncol

      Volume: 9 Issue: 9 Pages: 1354-1362

    • DOI

      10.1097/jto.0000000000000264

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A multicentre phase II study of vorinostat in patients with relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma.2014

    • Author(s)
      Ogura M, Ando K, Suzuki T, Ishizawa K, Oh SY, Itoh K, Yamamoto K, Au WY, Tien HF, Matsuno Y, Terauchi T, Yamamoto K, Mori M, Tanaka Y, Shimamoto T, Tobinai K, Kim WS.
    • Journal Title

      Br J Haematol

      Volume: 165 Issue: 6 Pages: 768-776

    • DOI

      10.1111/bjh.12819

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumor genetics and survival of thymic neuroendocrine neoplasms: A multi-institutional clinicopathologic study.2014

    • Author(s)
      Strobel P, Zettl A, Shilo K, Chuang WY, Nicholson A, Matsuno Y, Gal A, Hubert Laeng R, Engel P, Capella C, Marino M, Chan JK, Rosenwald A, Travis W, Franks TJ, Ellenberger D, Schaefer IM, Marx A
    • Journal Title

      Genes Chromosomes Cancer

      Volume: in press Issue: 9 Pages: 738-749

    • DOI

      10.1002/gcc.22183

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential expression of progesterone receptor, FOXA1, GATA3, and p53 between pre- and postmenopausal women with estrogen receptor-positive breast cancer.2014

    • Author(s)
      Hosoda M, Yamamoto M, Nakano K, Hatanaka KC, Takakuwa E, Hatanaka Y, Matsuno Y, Yamashita H
    • Journal Title

      Breast Cancer Res Treat.

      Volume: 144 Issue: 2 Pages: 249-61

    • DOI

      10.1007/s10549-014-2867-0

    • NAID

      120005600744

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] p53 accumulation is a strong predictor of recurrence in estrogen receptor-positive breast cancer patients treated with aromatase inhibitors.2014

    • Author(s)
      Yamamoto M, Hosoda M, Nakano K, Jia S, Hatanaka KC, Takakuwa E, Hatanaka Y, Matsuno Y, Yamashita H
    • Journal Title

      Cancer Sci

      Volume: 105 Issue: 1 Pages: 81-8

    • DOI

      10.1111/cas.12302

    • NAID

      120005411143

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of outcomes between autologous and allogeneic hematopoietic stem cell transplantation for peripheral T-cell lymphomas with central review of pathology.2013

    • Author(s)
      Kim SW, Yoon SS, Suzuki R, Matsuno Y, Yi HG, Yoshida T, Imamura M, Wake A, Miura K, Hino M, Ishikawa T, Kim JS, Maeda Y, Lee JJ, Kang HJ, Lee HS, Lee JH, Izutsu K, Fukuda T, Kim CW, Yoshino T, Ohshima K, Nakamura S, Nagafuji K, Suzumiya J, Harada M, Kim CS.
    • Journal Title

      Leukemia.

      Volume: 27 Issue: 6 Pages: 1394-1397

    • DOI

      10.1038/leu.2012.321

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of pathologic complete response and Ki67 expression after neoadjuvant chemotherapy in breast cancer2013

    • Author(s)
      Yoshioka T, Hosoda M, Yamamoto M, Taguchi K, Hatanaka KC, Takakuwa E, Hatanaka Y, Matsuno Y, Yamashita H
    • Journal Title

      Breast Cancer

      Volume: in press

    • NAID

      120005712472

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Human equilibrative nucleoside transporter 1 and Notch3 can predict gemcitabine effects in patients with unresectable pancreatic cancer.2013

    • Author(s)
      Eto K, Kawakami H, Kuwatani M, Kudo T, Abe Y, Kawahata S, Takasawa A, Fukuoka M, Matsuno Y, Asaka M, Sakamoto N.
    • Journal Title

      Br J Cancer

      Volume: 108 Issue: 7 Pages: 1488-1494

    • DOI

      10.1038/bjc.2013.108

    • NAID

      120005341786

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of outcomes between autologous and allogeneic hematopoietic stem cell transplantation for peripheral T-cell lymphomas with central review of pathology.2012

    • Author(s)
      Kim SW, Yoon SS, Suzuki R, Matsuno Y, et al.
    • Journal Title

      Leukemia

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver study.2012

    • Author(s)
      Thunnissen, E., Beasley, M. B., Borczuk, A. C., Brambilla, E.,. L., Motoi, N., et al.
    • Journal Title

      Mod Pathol

      Volume: 25 Issue: 12 Pages: 1574-1583

    • DOI

      10.1038/modpathol.2012.106

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] びまん性大細胞型B細胞リンパ腫のNKG2Dリガンド発現に関する免疫組織化学的検討2015

    • Author(s)
      藤澤 孝志,畑中 豊,畑中 佳奈子,三橋 智子,松野 吉宏,藤本 勝也
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 病理検体を用いるコンパニオン診断の精度保証2015

    • Author(s)
      松野 吉宏,丸川 活司,畑中 豊
    • Organizer
      第13回日本臨床腫瘍学会学術集会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Pediatric diffuse large B-cell lymphoma - A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)2015

    • Author(s)
      中澤 温子,大隅 朋生,鶴澤 正仁,小林 良二,岩淵 英人,大島 孝一,田丸 淳一,中峯 寛和,中村 栄男,藤本 純一郎,北條 洋,松野 吉宏,吉野 正
    • Organizer
      第55回日本リンパ網内系学会総会
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 自己免疫性疾患患者に生じたリンパ増殖性疾患63例の臨床病理学的検討2015

    • Author(s)
      畑中佳奈子、藤本勝也、野口寛子、高桑康成、畑中豊、松野吉宏、Lymphoma Clinico-Pathologic Conference
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2015-04-30 – 2015-05-02
    • Related Report
      2014 Research-status Report
  • [Presentation] 悪性リンパ腫の病理2015

    • Author(s)
      松野吉宏
    • Organizer
      第9回Tokyo FDG-PET Imaging Conference
    • Place of Presentation
      ベルサール神保町(東京都)
    • Year and Date
      2015-02-21
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] コンパニオン診断薬; 開発及び評価の考え方と課題2014

    • Author(s)
      松野吉宏
    • Organizer
      PMDAワークショップ
    • Place of Presentation
      全社協・灘尾ホール(東京都)
    • Year and Date
      2014-09-01
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 眼内悪性リンパ腫および鑑別疾患における硝子体液を用いた病理診断の有用2014

    • Author(s)
      菅野 宏美,藤田 裕美,畑中 佳奈子,田川 義晃,南場 研一,三橋 智子,松野 吉宏
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 自己免疫性疾患患者に発生した悪性リンパ腫を含むリンパ増殖性疾患に関する臨床病理学的解析.2014

    • Author(s)
      畑中 佳奈子,藤本 勝也,辻 嶐裕,笠原 郁美,山本 聡 ,中田 匡信,高桑 康成,西尾 充史,小山 田ゆみ子,長谷山 美仁,鈴木 宏明,米積 昌克,野口 寛子,酒井 基,西原 広史,盛 暁生,畑中 豊,豊嶋 崇徳,松野 吉宏
    • Organizer
      第54回 リンパ網内系学会
    • Place of Presentation
      山形国際ホテル(山形市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 中枢神経系原発びまん性大細胞型B細胞性リンパ腫におけるDNAメチル化に関する解析.2014

    • Author(s)
      畑中 佳奈子,畑中 豊,小林 浩之,菅野 宏美,西原 広史,田中 伸哉,三橋 智子,松野 吉宏
    • Organizer
      第103回 日本病理学会総会
    • Place of Presentation
      広島国際会議場(広島市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 眼内悪性リンパ腫および鑑別疾患における硝子体液を用いた病理診断の有用性.2014

    • Author(s)
      菅野 宏美,藤田 裕美,畑中 佳奈子,田川 義晃,南場 研一,三橋 智子,松野 吉宏
    • Organizer
      第103回 日本病理学会総会
    • Place of Presentation
      広島国際会議場(広島市)
    • Related Report
      2013 Research-status Report
  • [Presentation] コンパニオン診断の現状と今後の課題.2013

    • Author(s)
      畑中 豊,西尾 和人,松野 吉宏
    • Organizer
      第52回 日本臨床細胞学会秋期大会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ヒトHER2陰性luminalタイプ乳癌におけるNKG2Dリガンドの発現解析.2013

    • Author(s)
      畑中 豊,鈴木 雄太,藤田 裕美,畑中 佳奈子,大庭 幸治,三橋 智子,山下 啓子,笠原 正典,松野 吉宏
    • Organizer
      第102回 日本病理学会総会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒトHER2陰性luminalタイプ乳癌におけるNKG2Dリガンドの発現解析2013

    • Author(s)
      畑中豊,鈴木雄太,藤田裕美,畑中佳奈子,大庭幸治,三橋智子,山下啓子,笠原正典,松野吉宏
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] 分子病理診断の標準化と精度管理における課題と取り組み2012

    • Author(s)
      畑中豊,松野吉宏
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] Distinct roles of the progesterone receptor in estrogen receptor-positive breast cancer in pre- and postomenopausal wonen2012

    • Author(s)
      Hosoda M, Yamamoto M, Taguchi K, Matsuno Y, Yamashita H
    • Organizer
      15th International Congress on Hormonal Steroids and Hormones & Cancer
    • Place of Presentation
      Ishikawa Ongakudo (Ishikawa)
    • Related Report
      2012 Research-status Report
  • [Book] Mucoepidermoid carcinoma. In: World Health Organization Classification of Tumours, WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart, Chapter 3, Tumours of the thymus, William D. Travis, Elizabeth Brambilla, Allen P. Burke, Alexander Marx, Andrew G. Nicholson, (eds.)2015

    • Author(s)
      Y. Matsuno, J.K.C. Chan, F. Detterbeck, E.M. Marom, M. Wick.
    • Total Pages
      412
    • Publisher
      IARC Press
    • Related Report
      2015 Annual Research Report
  • [Book] 腫瘍とは 入門腫瘍内科学 改訂第2版,日本臨床腫瘍学会監修・「入門腫瘍内科学」編集委員会編集2015

    • Author(s)
      松野 吉宏,鍋島 一樹,河上 裕
    • Total Pages
      234
    • Publisher
      篠原出版新社
    • Related Report
      2015 Annual Research Report
  • [Book] 腫瘍病理鑑別診断アトラス-縦隔腫瘍・胸膜腫瘍2014

    • Author(s)
      深山 正久,野口 雅之,松野 吉宏(編)
    • Total Pages
      308
    • Publisher
      文光堂(東京)
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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