Role of NKG2D ligands in prediction of response to cancer antibody therapy

• Project/Area Number: 24590441
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Hokkaido University
• Principal Investigator: Matsuno Yoshihiro 北海道大学, 大学病院, 教授 (00199829)
• Co-Investigator(Kenkyū-buntansha): HATANAKA Yutaka 北海道大学, 北海道大学病院, 特任講師 (30589924)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: NKG2Dリガンド / 分子標的治療 / ADCC活性 / 治療効果予測

Outline of Final Research Achievements

In this study, we analyzed the protein expression profile of NKG2DL in breast cancer and malignant lymphoma, and examined the relationship with clinicopathological factors and patient survival to estimate an impact of NKG2DL modulation in antibody therapies. We showed that the clinicopathological significance of NKG2DL was different depending on molecular subtypes in breast cancer. Moreover, it was suggested that the significance of NKG2DL in rituximab-treated DLBCL might depend on cancer immunoresponse or cellular stress.

Research Products

• [Journal Article] Comparative genetic analysis of a rare synchronous collision tumor composed of malignant pleural mesothelioma and primary pulmonary adenocarcinoma (2016)
  • Author(s): Naka T, Hatanaka Y, Marukawa K, Okada H, Hatanaka KC, Sakakibara-Konishi J, Oizumi S, Hida Y, Kaga K, Mitsuhashi T, Matsuno Y
  • Journal Title: Diagnostic Pathology Volume: 11 Pages: 1-6
  • DOI: 10.1186/s13000-016-0488-0
  • NAID: 120005766752
  • Peer Reviewed / Open Access
• [Journal Article] Natural History of Pulmonary Subsolid Nodules: A Prospective Multicenter Study. (2016)
  • Author(s): Kakinuma R, Noguchi M, Ashizawa K, Kuriyama K, Maeshima AM, Koizumi N, Kondo T, Matsuguma H, Nitta N, Ohmatsu H, Okami J, Suehisa H, Yamaji T, Kodama K, Mori K, Yamada K, Matsuno Y, Murayama S, Murata K.
  • Journal Title: J Thorac Oncol. Volume: Epub ahead of print
  • DOI: 10.1016/j.jtho.2016.04.006
• [Journal Article] Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome (2016)
  • Author(s): Shiratori S, Fujimoto K, Nishimura M, Hatanaka KC, Kosugi-Kanaya M, Okada K, Sugita J, Shigematsu A, Hashimoto D, Endo T, Kondo T, Abe R, Hashino S, Matsuno Y, Shimizu H, Teshima T.
  • Journal Title: Hematol Oncol. Volume: Epub Ahead of Print Pages: 9-16
  • DOI: 10.1002/hon.2162
  • NAID: 120005981361
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of fucosyltransferase 8 is associated with an unfavorable clinical outcome in non-small cell lung cancers (2015)
  • Author(s): Honma R, Kinoshita I, Miyoshi E, Tomaru U, Matsuno Y, Shimizu Y, Takeuchi S, Kobayashi Y, Kaga K, Taniguchi N, Dosaka-Akita H
  • Journal Title: Oncology. Volume: 88 Pages: 298-305
  • DOI: 10.1159/000369495
  • Peer Reviewed
• [Journal Article] Importance of luminal membrane mesothelin expression in intraductal papillary mucinous neoplasms. (2015)
  • Author(s): Einama T, Kamachi H, Nishihara H, Homma S, Kanno H, Ishikawa M, Kawamata F, Konishi Y, Sato M, Tahara M, Okada K, Muraoka S, Kamiyama T, Taketomi A, Matsuno Y, Furukawa H, Todo S
  • Journal Title: Oncol Lett Volume: 9 Pages: 1583-1589
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Decreased proteasomal function accelerates cigarette smoke-induced pulmonary emphysema in mice. (2015)
  • Author(s): Yamada Y, Tomaru U, Ishizu A, Ito T, Kiuchi T, Ono A, Miyajima S, Nagai K, Higashi T, Matsuno Y, Dosaka-Akita H, Nishimura M, Miwa S, Kasahara M
  • Journal Title: Lab Invest. Volume: 95 Pages: 625-634
  • DOI: 10.1038/labinvest.2015.43
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Immunohistochemical validation and expression profiling of NKG2D ligands in a wide spectrum of human epithelial neoplasms. (2015)
  • Author(s): Fujita H, Hatanaka Y, Sutoh Y, Suzuki Y, Oba K, Hatanaka KC, Mitsuhashi T, Otsuka N, Fugo K, Kasahara M, Matsuno Y.
  • Journal Title: J Histochem Cytochem Volume: 63 Pages: 217-227
  • DOI: 10.1369/0022155414563800
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic biomarkers in patients with localized natural killer/T-cell lymphoma treated with concurrent chemoradiotherapy (2014)
  • Author(s): Yamaguchi M, Takata K, Yoshino T, Ishizuka N, Oguchi M, Kobayashi Y, Isobe Y, Ishizawa K, Kubota N, Itoh K, Usui N, Miyazaki K, Wasada I, Nakamura S, Matsuno Y, Oshimi K, Kinoshita T, Tsukasaki K, Tobinai K.
  • Journal Title: Cancer Sci. Volume: 105 Pages: 1435-1441
  • DOI: 10.1111/cas.12526
  • Peer Reviewed
• [Journal Article] Reproducibility of histopathological diagnosis in poorly differentiated NSCLC: an international multiobserver study. (2014)
  • Author(s): Thunnissen E, Noguchi M, Aisner S, Beasley MB, Brambilla E, Chirieac LR, Chung JH, Dacic S, Geisinger KR, Hirsch FR, Ishikawa Y, Kerr KM, Lantejoul S, Matsuno Y, Minami Y, Moreira AL, Pelosi G, Petersen I, Roggli V, Travis WD, Wistuba I, Yatabe Y, Dziadziuszko R, Witte B, Tsao MS, Nicholson AG.
  • Journal Title: J Thorac Oncol Volume: 9 Pages: 1354-1362
  • DOI: 10.1097/jto.0000000000000264
  • Peer Reviewed
• [Journal Article] A multicenter phase Ⅱ study of vorinostat in patients with relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma (2014)
  • Author(s): Ogura M, Ando K, Suzuki T, Ishizawa K, Oh SY, Itoh K, Yamamoto K, Au WY, Tien HF, Matsuno Y, Terauchi T, Yamamoto K, Mori M, Tanaka Y, Shimamoto T, Tobinai K, Kim WS.
  • Journal Title: Br J Haematol. Volume: 165 Pages: 768-776
  • DOI: 10.1111/bjh.12819
  • Peer Reviewed
• [Journal Article] Tumor genetics and survival of thymic neuroendocrine neoplasms: A multi-institutional clinicopathologic study. (2014)
  • Author(s): Strobel P, Zettl A, Shilo K, Chuang WY, Nicholson A, Matsuno Y, Gal A, Hubert Laeng R, Engel P, Capella C, Marino M, Chan JK, Rosenwald A, Travis W, Franks TJ, Ellenberger D, Schaefer IM, Marx A
  • Journal Title: Genes Chromosomes Cancer Volume: in press
  • DOI: 10.1002/gcc.22183
  • Peer Reviewed
• [Journal Article] Differential expression of progesterone receptor, FOXA1, GATA3, and p53 between pre- and postmenopausal women with estrogen receptor-positive breast cancer (2014)
  • Author(s): Hosoda M, Yamamoto M, Nakano K, Hatanaka KC, Takakuwa E, Hatanaka Y, Matsuno Y, Yamashita H
  • Journal Title: Breast Cancer Res Treat Volume: 144 Pages: 249-61
  • DOI: 10.1007/s10549-014-2867-0
  • NAID: 120005600744
  • Peer Reviewed
• [Journal Article] p53 accumulation is a strong predictor of recurrence in estrogen receptor-positive breast cancer patients treated with aromatase inhibitors. (2014)
  • Author(s): Yamamoto M, Hosoda M, Nakano K, Jia S, Hatanaka KC, Takakuwa E, Hatanaka Y, Matsuno Y, Yamashita H
  • Journal Title: Cancer Sci Volume: 105 Pages: 81-8
  • DOI: 10.1111/cas.12302
  • NAID: 120005411143
  • Peer Reviewed
• [Journal Article] Comparison of outcomes between autologous and allogeneic hematopoietic stem cell transplantation for peripheral T-cell lymphomas with central review of pathology (2013)
  • Author(s): Kim SW, Yoon SS, Suzuki R, Matsuno Y, Yi HG, Yoshida T, Imamura M, Wake A, Miura K, Hino M, Ishikawa T, Kim JS, Maeda Y, Lee JJ, Kang HJ, Lee HS, Lee JH, Izutsu K, Fukuda T, Kim CW, Yoshino T, Ohshima K, Nakamura S, Nagafuji K, Suzumiya J, Harada M, Kim CS.
  • Journal Title: Leukemia Volume: 27 Pages: 1394-1397
  • DOI: 10.1038/leu.2012.321
  • Peer Reviewed
• [Journal Article] Prognostic significance of pathologic complete response and Ki67 expression after neoadjuvant chemotherapy in breast cancer (2013)
  • Author(s): Yoshioka T, Hosoda M, Yamamoto M, Taguchi K, Hatanaka KC, Takakuwa E, Hatanaka Y, Matsuno Y, Yamashita H
  • Journal Title: Breast Cancer Volume: in press
  • NAID: 120005712472
  • Peer Reviewed
• [Journal Article] Human equilibrative nucleoside transporter 1 and Notch 3 can predict gemcitabine effects in patients with unresectable pancreatic cancer (2013)
  • Author(s): Eto K, Kawakami H, Kuwatani M, Kudo T, Abe Y, Kawahata S, Takasawa A, Fukuoka M, Matsuno Y, Asaka M, Sakamoto N.
  • Journal Title: British Journal of Cancer Volume: 108 Pages: 1488-1494
  • DOI: 10.1038/bjc.2013.108
  • NAID: 120005341786
  • Peer Reviewed
• [Journal Article] Comparison of outcomes between autologous and allogeneic hematopoietic stem cell transplantation for peripheral T-cell lymphomas with central review of pathology. (2012)
  • Author(s): Kim SW, Yoon SS, Suzuki R, Matsuno Y, et al.
  • Journal Title: Leukemia Volume: in press
  • Peer Reviewed
• [Journal Article] Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver study. (2012)
  • Author(s): Thunnissen, E., Beasley, M. B., Borczuk, A. C., Brambilla, E.,. L., Motoi, N., et al.
  • Journal Title: Mod Pathol Volume: 25 Pages: 1574-1583
  • DOI: 10.1038/modpathol.2012.106
  • Peer Reviewed
• [Presentation] びまん性大細胞型Ｂ細胞リンパ腫のNKG2Dリガンド発現に関する免疫組織化学的検討 (2015)
  • Author(s): 藤澤 孝志，畑中 豊，畑中 佳奈子，三橋 智子，松野 吉宏，藤本 勝也
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市)
  • Year and Date: 2015-10-08
• [Presentation] 病理検体を用いるコンパニオン診断の精度保証 (2015)
  • Author(s): 松野 吉宏，丸川 活司，畑中 豊
  • Organizer: 第13回日本臨床腫瘍学会学術集会
  • Place of Presentation: ロイトン札幌（北海道札幌市）
  • Year and Date: 2015-07-16
  • Invited
• [Presentation] Pediatric diffuse large B-cell lymphoma - A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) (2015)
  • Author(s): 中澤 温子，大隅 朋生，鶴澤 正仁，小林 良二，岩淵 英人，大島 孝一，田丸 淳一，中峯 寛和，中村 栄男，藤本 純一郎，北條 洋，松野 吉宏，吉野 正
  • Organizer: 第55回日本リンパ網内系学会総会
  • Place of Presentation: 岡山コンベンションセンター（岡山県岡山市）
  • Year and Date: 2015-07-09
• [Presentation] 自己免疫性疾患患者に生じたリンパ増殖性疾患63例の臨床病理学的検討 (2015)
  • Author(s): 畑中佳奈子、藤本勝也、野口寛子、高桑康成、畑中豊、松野吉宏、Lymphoma Clinico-Pathologic Conference
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-04-30 – 2015-05-02
• [Presentation] 悪性リンパ腫の病理 (2015)
  • Author(s): 松野吉宏
  • Organizer: 第9回Tokyo FDG-PET Imaging Conference
  • Place of Presentation: ベルサール神保町（東京都）
  • Year and Date: 2015-02-21
  • Invited
• [Presentation] 自己免疫性疾患患者に発生した悪性リンパ腫を含むリンパ増殖性疾患に関する臨床病理学的解析． (2014)
  • Author(s): 畑中 佳奈子，藤本 勝也，辻 嶐裕，笠原 郁美，山本 聡 ，中田 匡信，高桑 康成，西尾 充史，小山 田ゆみ子，長谷山 美仁，鈴木 宏明，米積 昌克，野口 寛子，酒井 基，西原 広史，盛 暁生，畑中 豊，豊嶋 崇徳，松野 吉宏
  • Organizer: 第54回 リンパ網内系学会
  • Place of Presentation: 山形国際ホテル（山形市）
• [Presentation] 中枢神経系原発びまん性大細胞型B細胞性リンパ腫におけるDNAメチル化に関する解析． (2014)
  • Author(s): 畑中 佳奈子，畑中 豊，小林 浩之，菅野 宏美，西原 広史，田中 伸哉，三橋 智子，松野 吉宏
  • Organizer: 第103回 日本病理学会総会
  • Place of Presentation: 広島国際会議場（広島市）
• [Presentation] 眼内悪性リンパ腫および鑑別疾患における硝子体液を用いた病理診断の有用性． (2014)
  • Author(s): 菅野 宏美，藤田 裕美，畑中 佳奈子，田川 義晃，南場 研一，三橋 智子，松野 吉宏
  • Organizer: 第103回 日本病理学会総会
  • Place of Presentation: 広島国際会議場（広島市）
• [Presentation] コンパニオン診断薬; 開発及び評価の考え方と課題 (2014)
  • Author(s): 松野吉宏
  • Organizer: PMDAワークショップ
  • Place of Presentation: 全社協・灘尾ホール（東京都）
  • Year and Date: 2014-09-01
  • Invited
• [Presentation] 眼内悪性リンパ腫および鑑別疾患における硝子体液を用いた病理診断の有用 (2014)
  • Author(s): 菅野 宏美，藤田 裕美，畑中 佳奈子，田川 義晃，南場 研一，三橋 智子，松野 吉宏
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島国際会議場（広島市）
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] コンパニオン診断の現状と今後の課題． (2013)
  • Author(s): 畑中 豊，西尾 和人，松野 吉宏
  • Organizer: 第52回 日本臨床細胞学会秋期大会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Invited
• [Presentation] ヒトHER2陰性luminalタイプ乳癌におけるNKG2Dリガンドの発現解析． (2013)
  • Author(s): 畑中 豊，鈴木 雄太，藤田 裕美，畑中 佳奈子，大庭 幸治，三橋 智子，山下 啓子，笠原 正典，松野 吉宏
  • Organizer: 第102回 日本病理学会総会
  • Place of Presentation: ロイトン札幌（札幌市）
• [Presentation] ヒトHER2陰性luminalタイプ乳癌におけるNKG2Dリガンドの発現解析 (2013)
  • Author(s): 畑中豊，鈴木雄太，藤田裕美，畑中佳奈子，大庭幸治，三橋智子，山下啓子，笠原正典，松野吉宏
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌（北海道）
• [Presentation] 分子病理診断の標準化と精度管理における課題と取り組み (2012)
  • Author(s): 畑中豊，松野吉宏
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 京王プラザホテル（東京都）
• [Presentation] Distinct roles of the progesterone receptor in estrogen receptor-positive breast cancer in pre- and postomenopausal wonen (2012)
  • Author(s): Hosoda M, Yamamoto M, Taguchi K, Matsuno Y, Yamashita H
  • Organizer: 15th International Congress on Hormonal Steroids and Hormones & Cancer
  • Place of Presentation: Ishikawa Ongakudo (Ishikawa)
• [Book] Mucoepidermoid carcinoma. In: World Health Organization Classification of Tumours, WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart, Chapter 3, Tumours of the thymus, William D. Travis, Elizabeth Brambilla, Allen P. Burke, Alexander Marx, Andrew G. Nicholson, (eds.) (2015)
  • Author(s): Y. Matsuno, J.K.C. Chan, F. Detterbeck, E.M. Marom, M. Wick.
  • Total Pages: 412
  • Publisher: IARC Press
• [Book] 腫瘍とは 入門腫瘍内科学 改訂第2版，日本臨床腫瘍学会監修・「入門腫瘍内科学」編集委員会編集 (2015)
  • Author(s): 松野 吉宏，鍋島 一樹，河上 裕
  • Total Pages: 234
  • Publisher: 篠原出版新社
• [Book] 腫瘍病理鑑別診断アトラス－縦隔腫瘍・胸膜腫瘍 (2014)
  • Author(s): 深山 正久，野口 雅之，松野 吉宏（編）
  • Total Pages: 308
  • Publisher: 文光堂（東京）