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Histological comparison of fibroblastic stromal cells in cancer microenvironment

Research Project

Project/Area Number 24590442
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionTohoku University

Principal Investigator

MIKI Yasuhiro  東北大学, 災害科学国際研究所, 講師 (50451521)

Research Collaborator HATA Shuko  東北大学, 医学系研究科, ポスドク (90466532)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords癌間質細胞 / 肺癌 / 乳癌 / 癌間質相互作用 / 血管新生 / 扁平上皮癌 / 腺癌 / 3次元培養 / 癌微小環境 / 線維芽細胞
Outline of Final Research Achievements

It is well known that intratumoral stromal cells exert important role on cancer proliferation and invasion in several types of cancer. However, the histological differences in the cell growth and angiogenesis of cancer remain unclear. In this study, we established fibroblast-like stromal cell (FSC) derived from breast and lung carcinoma tissues, respectively. There were no differences in the cancer cell growth between the FSC derived from squamous cell carcinoma and adenocarcinoma of the lung, but considerable differences in tubular formation of endothelial cells were observed between the two histologic types.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Invited: 3 results)

  • [Journal Article] Tissue concentrations of estrogens and aromatase immunolocalization in interstitial pneumonia of human lung.2014

    • Author(s)
      Taniuchi S, Fujishima F, Miki Y, Abe K, Nakamura Y, Sato S, Kasajima A, Fue M, Ishida K, Watanabe M, Sakakibara T, Maeda S, Suzuki T, Sasano H.
    • Journal Title

      Mol Cell Endocrinol.

      Volume: 392 Pages: 136-143

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Activation of AXL and antitumor effects of a monoclonal antibody to AXL in lung adenocarcinoma.2014

    • Author(s)
      Iida S, Miki Y, Suzuki T, Mori K, Saito M, Niikawa H, Kondo T, Yamada-Okabe H, Sasano H.
    • Journal Title

      Anticancer Res.

      Volume: 34 Pages: 1821-1827

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The advantages of co-culture over mono cell culture in simulating in vivo environment2012

    • Author(s)
      Yasuhiro Miki, Katsuhiko Ono, Shuko Hata, Takashi Suzuki, Hiroyuki Kumamoto, Hironobu Sasano
    • Journal Title

      The Journal of Steroid Biochemistry and Molecular Biology

      Volume: (未定)(印刷中) Issue: 3-5 Pages: 68-75

    • DOI

      10.1016/j.jsbmb.2011.12.004

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ストレスホルモンと癌:子宮内膜癌におけるコルチゾール代謝2014

    • Author(s)
      三木康宏、髙木清司、鈴木 貴、笹野公伸、伊藤 潔
    • Organizer
      ホルモンと癌研究会
    • Place of Presentation
      艮陵会館(仙台市)
    • Year and Date
      2014-07-04 – 2014-07-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Intratumoral Concentration of Stress Hormone, Cortisol in Endometrial Carcinoma2014

    • Author(s)
      Yasuhiro MIKI, Kiyoshi TAKAGI, Zhulanqiqige DOE, Sota TANAKA, Takashi SUZUKI, Hironobu SASANO, Kiyoshi ITO
    • Organizer
      16th International Congress of Endocrinology/The 96th Annual Meeting of The Endocrine Society
    • Place of Presentation
      McCormick Place(Chicago, USA)
    • Year and Date
      2014-06-21 – 2014-06-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] LIN28Bの乳癌における臨床病理学的意義2013

    • Author(s)
      櫻井美奈子、三木康宏、柴原裕紀子、平川 久、鈴木 貴、大内憲明、笹野公伸
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Intratumoral Concentration of Stress Hormone Cortisol in Endometrial Carcinoma2013

    • Author(s)
      Yasuhiro MIKI, Kiyoshi TAKAGI, Takashi SUZUKI, Kiyoshi ITO
    • Organizer
      NIH-Tohoku Universtity-JSPS Symposium
    • Place of Presentation
      艮陵会館(仙台市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Msi1 Enhances LIN28B Mediated Pathogenesis in Breast Cancer2013

    • Author(s)
      Minako Sakurai, Yasuhiro Miki, Yukiko Shibara, Hisashi Hirakawa, Noriaki Ohuchi, Takashi Suzuki, Hironobu Sasano
    • Organizer
      NIH-Tohoku Universtity-JSPS Symposium
    • Place of Presentation
      艮陵会館(仙台市)
    • Related Report
      2013 Research-status Report
  • [Presentation] A Role for p62/SQSTM1 as a Crucial Mediator of Autophagy during Cancer Progression2013

    • Author(s)
      Kaito NIHIRA, Yasuhiro MIKI, Katsuhiko ONO, Takashi SUZUKI, Hironobu SASANO
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Lung Cancer: An Estrogen Target?2012

    • Author(s)
      Yasuhiro MIKI
    • Organizer
      ENDO 2012 -The 94th Annual Meeting of The Endocrine Society-
    • Place of Presentation
      ヒューストン アメリカ合衆国
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Ligand-dependent and independent activation of Axl in non-small cell lung carcinoma2012

    • Author(s)
      Shinya IIDA, Yasuhiro MIKI, Yasuhiro NAKAMURA, Takashi SUZUKI, Hisafumi OKABE, Hironobu SASANO
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Research-status Report
  • [Presentation] Endocrine disrupting effects of cigarette smoking2012

    • Author(s)
      Yasuhiro MIKI, Takashi SUZUKI, Satoshi SUZUKI, Kiyoshi ITO, Hiroyuki KUMAMOTO, Hironobu SASANO
    • Organizer
      15th International Congress on Hormonal Steroids and Hormones & Cancer
    • Place of Presentation
      金沢市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 肺癌および乳癌における腫瘍マーカーとしてのp62/SQSTM1の意義

    • Author(s)
      仁平開人、三木康宏、鈴木 貴、笹野公伸
    • Organizer
      第32回日本分子腫瘍マーカー研究会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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