Epigenetic alterations and tumor heterogeneity in gastric cancers
| Project/Area Number |
24590444
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AKIYAMA Yoshimitsu 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (80262187)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | メチル化 / ヒストン / 胃がん / エピジェネティクス / 組織内多様性 / 組織多様性 / ヒストン修飾 / 転写因子 |
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| Outline of Final Research Achievements |
In this study, we focused on the relationship between epigenetic changes of genes and tumor heterogeneity of gastric cancers (GCs). Expression of SET7/9, a histone mono-methyltransferase, was frequently reduced in primary GCs, some of which expression patterns were distinct within a GC tissue. SET7/9 regulated several differentiation-related gene expression and had tumor suppressive functions. In addition, several mouse GC cell lines showing distinct Twist1 expression pattern were established from the p53/E-cadherin double knockout mice. Twist1 expression was epigenetically regulated by DNA methylation, histone modification and binding of transcription factor Sp1 in these mouse GC cells. Our data suggest that tumor heterogeneity of GCs may be related to epigenetic alterations.
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Report
(5 results)
Research Products
(38 results)
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[Journal Article] Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression.2016
Author(s)
Akiyama Y, Koda Y, Byeon S, Shimada S, Nishikawaji T, Sakamoto A, Chen Y, Kojima K, Kawano T, Eishi Y, Deng D, Kim WH, Zhu WG, Yuasa Y, Tanaka S.
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Journal Title
Oncotarget
Volume: 7(4)
Issue: 4
Pages: 3966-3983
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability.2013
Author(s)
Wang D, Zhou J, Liu X, Lu D, Shen C, Du Y, Wei FZ, Song B, Lu X, Yu Y, Wang L, Zhao Y, Wang H, Yang Y, Akiyama Y, Zhang H, Zhu WG.
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Journal Title
Proceedings of the National Academy of Sciences of the United States of America
Volume: 110
Issue: 14
Pages: 5516-5521
DOI
Related Report
Peer Reviewed
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