| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
In this study, we focused on the relationship between epigenetic changes of genes and tumor heterogeneity of gastric cancers (GCs). Expression of SET7/9, a histone mono-methyltransferase, was frequently reduced in primary GCs, some of which expression patterns were distinct within a GC tissue. SET7/9 regulated several differentiation-related gene expression and had tumor suppressive functions. In addition, several mouse GC cell lines showing distinct Twist1 expression pattern were established from the p53/E-cadherin double knockout mice. Twist1 expression was epigenetically regulated by DNA methylation, histone modification and binding of transcription factor Sp1 in these mouse GC cells. Our data suggest that tumor heterogeneity of GCs may be related to epigenetic alterations.
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