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Screening of target genes for chromosome 20q

Research Project

Project/Area Number 24590446
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionOita University

Principal Investigator

TSUKAMOTO Yoshiyuki  大分大学, 医学部, 助教 (00433053)

Co-Investigator(Kenkyū-buntansha) YANAGIHARA Kazuyoshi  国立研究開発法人国立がん研究センター, 臨床開発センター (20158025)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords胃癌 / 20q13 / DDX27 / 治療 / 20番染色体
Outline of Final Research Achievements

Previously, we have reported that gain at chromosome 20q13 is the most common genomic copy number aberration in gastric cancer (GC) (29/30 cases), and that among the genes located in this region, we have identified DDX27 as a candidate target for GC. Here, we analyzed the significance of DDX27 upregulation in GC cells. We found that DDX27 was frequently upregulated in GC tissues, and significantly associated with venous invasion and liver metastasis. Furthermore, high expression of DDX27 was independently associated with poorer prognosis. Knockdown of DDX27 reduced the ability of GC cells to form colonies, but had little effect on their invasiveness. We also found that knockdown of DDX27 reduced the viability of GC cells through inhibition of cell cycle progression independently of apoptosis. Thus, our results suggest that expression of DDX27 contributes to colony formation by GC cells through cell cycle control and may be a potential therapeutic target for GC patients.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2015 2014 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Downregulation of NDUFB6 due to 9p24.1-p13.3 loss is implicated in metastatic clear cell renal cell carcinoma.2015

    • Author(s)
      Narimatsu T, *Matsuura K, Nakada C, Tsukamoto Y, Hijiya N, Kai T, Inoue T, Uchida T, Nomura T, Sato F, Seto M, Takeuchi I, Mimata H, Moriyama M
    • Journal Title

      Cancer Medicine

      Volume: 4(1) Issue: 1 Pages: 112-124

    • DOI

      10.1002/cam4.351

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Helicobacter pylori infection introduces DNA double-strand breaks in host cells2014

    • Author(s)
      Hanada K, Uchida T, Tsukamoto Y, Watada M, Yamaguchi N, Yamamoto K, Shiota S, Moriyama M, Graham DY, Yamaoka Y
    • Journal Title

      Infect Immun.

      Volume: 82 Issue: 10 Pages: 4182-4189

    • DOI

      10.1128/iai.02368-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Commensal microbiota contributes to chronic endocarditis in TAX1BP1 deficient mice.2013

    • Author(s)
      Nakano S, Ikebe E, Tsukamoto Y, Wang Y, Matsumoto T, Mitsui T, Yahiro T, Inoue K, Kawazato H, Yasuda A, Ito K, Yokoyama S, Takahashi N, Hori M, Shimada T, Moriyama M, Kubota T, Ono K, Fujibuchi W, Jeang KT, Iha H, Nishizono A.
    • Journal Title

      PLoS One

      Volume: 8(9) Issue: 9 Pages: e73205-e73205

    • DOI

      10.1371/journal.pone.0073205

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genomic profiling of oral squamous cell carcinomaby array-based comparative genomic hybridization2013

    • Author(s)
      Yoshioka S, Tsukamoto Y, Hijiya N, Nakada C, Uchida T, Matsuura K, Takeuchi I, Seto M, Kawano K, Moriyama M
    • Journal Title

      PLoS One

      Volume: 8(2) Issue: 2 Pages: 56165-56165

    • DOI

      10.1371/journal.pone.0056165

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC22013

    • Author(s)
      Matsuo M, Nakada C, Tsukamoto Y, Noguchi T, Uchida T, Hijiya N, Matsuura K, Moriyama M
    • Journal Title

      Mol Cancer

      Volume: 12 Issue: 1 Pages: 15-15

    • DOI

      10.1186/1476-4598-12-15

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2.2013

    • Author(s)
      Matsuo M, Nakada C, Tsukamoto Y, Noguchi T, Uchida T, Hijiya N, Matsuura K, Moriyama M
    • Journal Title

      Molecular Cancer

      Volume: 12(1) Pages: 15-15

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genomic profiling of renal cell carcinoma in patients with end-stage renal disease.2012

    • Author(s)
      Inoue T, Matsuura K, Yoshimoto T, Nguyen LT, Tsukamoto Y, Nakada C et al.
    • Journal Title

      Cancer Science

      Volume: 103(3) Pages: 569-76

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Genome-wide Analysis of DNA Copy Number Aberrations in Gastric Cancer2013

    • Author(s)
      Yoshiyuki Tsukamoto
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      Tokyo Bay Maihama Hotel Club & Resorts(千葉県浦安市)
    • Related Report
      2013 Research-status Report
  • [Presentation] The relationship between the 14-3-3zeta expression pattern and the clinicopathological variables of the 192 gastric cancer patients2013

    • Author(s)
      Aizawa T, Tsukamoto Y, Moriyama M, Noguchi T
    • Organizer
      AACR 104th Annual meeting, Washington, poster 1161
    • Place of Presentation
      Washington Convention Center
    • Related Report
      2012 Research-status Report
  • [Presentation] 胃癌におけるmiR-29cの発現機能解析2012

    • Author(s)
      塚本善之、松尾光浩、野口剛、中田知里、内田智久、守山正胤
    • Organizer
      第23回 日本消化器癌発生学会総会、徳島、ポスターP-5-6
    • Place of Presentation
      徳島ルネッサンスリゾートナルト
    • Related Report
      2012 Research-status Report
  • [Presentation] MiR-29c is downregulated in gastric cancers and regulates cell proliferation by targeting RCC2

    • Author(s)
      Yoshiyuki Tsukamoto
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Research-status Report
  • [Remarks] 大分大学医学部分子病理学講座

    • URL

      http://www.med.oita-u.ac.jp/byori2/index.htm

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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