| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we employed 19 informative microsatellite markers at 8p21-23.2 to compare the frequency of microsatellite instability (MSI) in 183 cases of adenocarcinoma (ADC), 81 cases of squamous cell carcinoma (SqCC), and 42 cases of neuroendocrine tumor (NET), which including 21 cases of large cell neuroendocrine carcinoma and 21 cases of small cell carcinoma in a PCR-based microallelotyping analysis. The frequency of MSI at 8p23.2, 8p23.1, 8p22 and 8p21 was 20%, 51%, 24% and 15% in 306 cases of primary lung cancer, respectively. MSI at 8p23.1 was significantly more frequent than other regions in any histologic types of lung cancer (P<0.05). More specifically, the frequency of MSI at marker D8S1819 was significantly higher than others. On the other hand, MSI at markers D8S264 and D8S1109 were showed more frequent in both ADC and NET, but not SqCC. These findings suggesting that multiple candidate TSGs reside on the 8p23 are early events during the carcinogenesis in the lung.
|
